6-Bromo-3,4-dihydro-1H-[1,8]naphthyridin-2-one

Product Name: 6-Bromo-3,4-dihydro-1H-[1,8]naphthyridin-2-one
CAS No.: 129686-16-4
Chemical Name: 6-Bromo-3,4-dihydro-1H-[1,8]naphthyridin-2-one
Synonyms: 6-BROMO-3,4-DIHYDRO-1,8-NAPHTHYRIDIN-2(1H)-ONE;4-dihydro-1H-[1;8]naphthyridin-2-one;6-Bromo-3,4-dihydro-1H-1,8phthyridin-2-one;6-Bromo-3,4-dihydro-1H-[1,8]naphthyrid-2-one;6-bromo-4,8-dihydro-3H-1,8-naphthyridin-2-one;6-Bromo-3,4-dihydro-1,8-naphthyridin-2(1H)-on;6-BROMO-3,4-DIHYDRO-1H-[1,8]NAPHTHYRIDIN-2-ONE;6-bioMo-3,4-dihydro-1H-[1,8]naphthyridin-2-one;6-bromo-3,4-dihydro-1,8-naphthyridin-2(8H)-one
CBNumber: CB1451838
Molecular Formula: C8H7BrN2O
Formula Weight: 227.06
MOL File: 129686-16-4.mol

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6-Bromo-3,4-dihydro-1H-[1,8]naphthyridin-2-one Property

Melting point:: 265-267°C
Boiling point:: 300.9±52.0 °C(Predicted)
Density: 1.83±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO
form: Solid
pka: 2.69±0.20(Predicted)
color: Off- White to Yellow
InChI: InChI=1S/C8H7BrN2O/c9-6-3-5-1-2-7(12)11-8(5)10-4-6/h3-4H,1-2H2,(H,10,11,12)
InChIKey: VJEOGGNIBLORIJ-UHFFFAOYSA-N
SMILES: N1C2C(=CC(Br)=CN=2)CCC1=O

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B684035
Product name: 6-Bromo-3,4-dihydro-1H-[1,8]naphthyridin-2-one
Packaging: 2g
Price: $370
Updated: 2021/12/16

AK Scientific

Product number: J97274
Product name: 6-Bromo-3,4-dihydro-1H-[1,8]naphthyridin-2-one
Packaging: 5g
Price: $255
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB19107
Product name: 6-Bromo-3,4-dihydro-1H-[1,8]naphthyridin-2-one
Packaging: 5G
Price: $540
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0013682
Product name: 6-BROMO-3,4-DIHYDRO-1H-[1,8]NAPHTHYRIDIN-2-ONE
Purity: 95.00%
Packaging: 100MG
Price: $779.63
Updated: 2021/12/16

Matrix Scientific

Product number: 072494
Product name: 6-Bromo-3,4-dihydro-1H-[1,8]naphthyridin-2-one
Purity: 95+%
Packaging: 5g
Price: $472
Updated: 2021/12/16

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6-Bromo-3,4-dihydro-1H-[1,8]naphthyridin-2-one Chemical Properties,Usage,Production

Chemical Properties

Off- White to Yellow Solid

Synthesis

335031-10-2

129686-16-4

General procedure for the synthesis of 6-bromo-3,4-dihydro-1H-[1,8]naphthyridin-2-one from methyl 6-bromo-2-oxo-1,2,3,4-tetrahydro-1,8-naphthyridine-3-carboxylate: (c) 6-Bromo-3,4-dihydro-1H-1,8-naphthyridin-2-one (2.00 g, 7.0 mmol) was dissolved in CH3OH (75 mL) and 1.0 M NaOH solution (30 mL) was added. The reaction mixture was heated to reflux for 4 hours and subsequently cooled to room temperature. The reaction solution was neutralized with 1.0 M HCl (30 mL) and heated to reflux again overnight. The reaction slurry was concentrated to dryness and the residue was suspended with 95:5 CHCl3/CH3OH. The insoluble material was removed by filtration and the filtrate was concentrated to afford 6-bromo-3,4-dihydro-1H-[1,8]naphthyridin-2-one (1.40 g, 88% yield) as an off-white solid: mass spectra (electrospray ionization) m/e 228 (M + H)+.

References

[1] Patent: EP1226138, 2004, B1
[2] Patent: WO2011/61214, 2011, A1. Location in patent: Page/Page column 32
[3] Patent: WO2014/193647, 2014, A2. Location in patent: Paragraph 0288
[4] Patent: CN104119331, 2018, B. Location in patent: Paragraph 0836; 0851; 0852
[5] Journal of Medicinal Chemistry, 2003, vol. 46, # 9, p. 1627 - 1635

6-Bromo-3,4-dihydro-1H-[1,8]naphthyridin-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Bromo-3,4-dihydro-1H-[1,8]naphthyridin-2-one Suppliers

Canada 1 China 116 India 1 United Kingdom 2 United States 10 Global 130

Suzhou Sino Rare Chemical Co., Ltd.

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View Lastest Price from 6-Bromo-3,4-dihydro-1H-[1,8]naphthyridin-2-one manufacturers

Career Henan Chemical Co

Product: 6-Bromo-3,4-dihydro-1H-[1,8]naphthyridin-2-one 129686-16-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-07-11

Career Henan Chemical Co

Product: 2-(2,2,2-TRIFLUOROETHOXY)PYRIDINE-3-CARBONITRILE 175277-89-1
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99%
Supply Ability: 1ton
Release date: 2019-07-11

129686-16-4, 6-Bromo-3,4-dihydro-1H-[1,8]naphthyridin-2-oneRelated Search:

6-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride 6-BROMO-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZINE 6-BROMO-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE 6-BroMo-3-Methyl-2-pyridinaMine 2-Bromonaphthalene Nalidixic acid Malaridine Bromine 3,4-Dihydro-1,8-naphthyridin-2(1H)-one METHYL 6-BROMO-2-OXO-1,2,3,4-TETRAHYDRO-1,8-NAPHTHYRIDINE-3-CARBOXYLATE 2-Amino-5-bromo-3-methylpyridine 2-Acetylamino-5-bromo-3-methylpyridine 8-Bromo-3,4-dihydro-1H-[1,6]naphthyridin-2-one 1,2,3,4-TETRAHYDRO-1,8-NAPHTHYRIDINE Pyridine, 3-bromo-5-ethyl- (9CI) 5,6,7,8-Tetrahydro-[1,8]naphthyridine-3-bromide 6-Bromo-3,4-dihydro-1H-[1,8]naphthyridin-2-one 6-BROMO-2-OXO-1,2,3,4-TETRAHYDRO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID

6-BROMO-3,4-DIHYDRO-1H-[1,8]NAPHTHYRIDIN-2-ONE

6-BROMO-3,4-DIHYDRO-1,8-NAPHTHYRIDIN-2(1H)-ONE

6-Bromo-3,4-dihydro-1,8-naphthyridin-2(1H)-on

6-Bromo-3,4-dihydro-1H-[1,8]naphthyrid-2-one

1,8-Naphthyridin-2(1H)-one,6-broMo-3,4-dihydro-

6-Bromo-2-oxo-1,2,3,4-tetrahydro-1,8-naphthyridine

6-broMo-1,2,3,4-tetrahydro-1,8-naphthyridin-2-one

6-bioMo-3,4-dihydro-1H-[1,8]naphthyridin-2-one

6-Bromo-3,4-dihydro-1H-1,8phthyridin-2-one

6-bromo-4,8-dihydro-3H-1,8-naphthyridin-2-one

6-bromo-3,4-dihydro-1h - [1,8] naphthidine-2-one

6-bromo-3,4-dihydro-1,8-naphthyridin-2(8H)-one

4-dihydro-1H-[1

8]naphthyridin-2-one

129686-16-4

Aromatics Compounds

pyridine

Aromatics

Heterocycles