6-BROMO-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZINE
- Product Name
- 6-BROMO-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZINE
- CAS No.
- 959992-62-2
- Chemical Name
- 6-BROMO-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZINE
- Synonyms
- 6-BROMO-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZINE;2H-Pyrido[3,2-b]-1,4-oxazine, 6-bromo-3,4-dihydro-
- CBNumber
- CB22451017
- Molecular Formula
- C7H7BrN2O
- Formula Weight
- 215.05
- MOL File
- 959992-62-2.mol
6-BROMO-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZINE Property
- Boiling point:
- 333.2±42.0 °C(Predicted)
- Density
- 1.619±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 2.83±0.20(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B689115
- Product name
- 6-Bromo-3,4-dihydro-2H-Pyrido[3,2-b]-1,4-oxazine
- Packaging
- 1g
- Price
- $770
- Updated
- 2021/12/16
- Product number
- Z5415
- Product name
- 6-Bromo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine
- Packaging
- 1g
- Price
- $320
- Updated
- 2021/12/16
- Product number
- OR346538
- Product name
- 6-Bromo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine
- Purity
- 95+%
- Packaging
- 500mg
- Price
- $411
- Updated
- 2021/12/16
- Product number
- 119245
- Product name
- 6-Bromo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $486
- Updated
- 2021/12/16
- Product number
- HCH0359717
- Product name
- 6-BROMO-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.14
- Updated
- 2021/12/16
6-BROMO-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZINE Chemical Properties,Usage,Production
Uses
6-?Bromo-?3,?4-?dihydro-2H-?Pyrido[3,?2-?b]?-?1,?4-?oxazine is a starting material and useful building blocks of various pharmaceuticals.
Synthesis
337463-88-4
959992-62-2
Step 4: To a solution of 6-bromo-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one (3.12 g, 13.7 mmol) in tetrahydrofuran (50 mL) was slowly added borane-tetrahydrofuran complex (33 mL, 33.0 mmol) at room temperature. The reaction mixture was heated to 90 °C and stirred continuously for 1.5 hours. Upon completion of the reaction, methanol (2.0 mL) was slowly added to quench the reaction and stirring was continued at 90 °C for 20 minutes. Subsequently, the reaction mixture was concentrated under reduced pressure to remove the solvent. The residue was dissolved in ethyl acetate, washed with saturated aqueous sodium bicarbonate, dried over anhydrous magnesium sulfate, and finally concentrated under reduced pressure to afford 6-bromo-3,4-dihydro-2H-pyrido[3,2-B][1,4]oxazine (3.17 g, 100% yield), the product was a yellow powder.1H-NMR (DMSO-d6) δ: 7.04 (1H, br s). 6.69 (1H, d, J = 7.8 Hz), 6.40 (1H, d, J = 7.8 Hz), 3.91 (2H, t, J = 4.2 Hz), 3.19-3.23 (2H, m).LC/MS (Method A): 1.44 min, [M + H]+ = 215.2.
References
[1] Patent: EP2341052, 2011, A1. Location in patent: Page/Page column 35; 36
[2] Patent: CN108623615, 2018, A. Location in patent: Paragraph 0388; 0389; 0390
[3] Patent: WO2013/169864, 2013, A2. Location in patent: Paragraph 00205
6-BROMO-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
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