6-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride
- Product Name
- 6-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride
- CAS No.
- 105655-01-4
- Chemical Name
- 6-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride
- Synonyms
- 6-Bromo-3,4-dihydro-2H-1,4-benzoxazine;6-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine;2H-1,4-Benzoxazine, 6-bromo-3,4-dihydro-;6-Bromo-3,4-dihydro-2H-1,4-benzoxazine,97%;6-bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine;6-BroMo-3,4-dihydro-2H-benzo[b][1,4]oxazine HCl;6-BROMO-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE;6-Bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine
- CBNumber
- CB8850760
- Molecular Formula
- C8H8BrNO
- Formula Weight
- 214.06
- MOL File
- 105655-01-4.mol
6-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride Property
- Boiling point:
- 296.4±40.0 °C(Predicted)
- Density
- 1.534±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- solid
- pka
- 3.59±0.20(Predicted)
- Appearance
- Light brown to orange Solid-liquid mixture
- InChI
- InChI=1S/C8H8BrNO/c9-6-1-2-8-7(5-6)10-3-4-11-8/h1-2,5,10H,3-4H2
- InChIKey
- RWKBNMSHIJBNAO-UHFFFAOYSA-N
- SMILES
- O1C2=CC=C(Br)C=C2NCC1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- VBP00109
- Product name
- 6-Bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine
- Packaging
- 1g
- Price
- $497
- Updated
- 2025/07/31
- Product number
- B683535
- Product name
- 6-Bromo-3,4-dihydro-2H-1,4-benzoxazine
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- B683535
- Product name
- 6-Bromo-3,4-dihydro-2H-1,4-benzoxazine
- Packaging
- 2.5g
- Price
- $220
- Updated
- 2021/12/16
- Product number
- 131801
- Product name
- 6-Bromo-3,4-dihydro-2H-benzo-[b][1,4]oxazinehydrochloride
- Purity
- 97%
- Packaging
- 25g
- Price
- $3592
- Updated
- 2021/12/16
- Product number
- HCH0410301
- Product name
- 6-BROMO-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $3811.5
- Updated
- 2021/12/16
6-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride Chemical Properties,Usage,Production
Uses
6-Bromo-3,4-dihydro-2H-1,4-benzoxazine is a reactant used for the synthesis of N-dichloroacetyl-3,4-dihydro-2H-1,4-benzoxazine derivatives.
Synthesis
24036-52-0
105655-01-4
General procedure for the synthesis of 6-bromo-3,4-dihydro-2H-benzo[1,4]oxazines from 6-bromo-2H-1,4-benzoxazin-3(4H)-ones: at room temperature, the borane-tetrahydrofuran complex (13.2 mL of a 1 M solution of tetrahydrofuran, 13.2 mmol) was added batchwise to intermediate 6 (2.0 g, 8.0 mmol) in a tetrahydrofuran ( 50 mL) solution. The reaction mixture was stirred for 10 minutes at room temperature and then heated to reflux for 1 hour, followed by cooling to room temperature. The reaction mixture was cooled in an ice bath and the reaction was quenched sequentially with water (20 mL) and 2 N aqueous sodium hydroxide solution (20 mL). The solvent was removed by rotary evaporator and the resulting mixture was diluted with water (100 mL). The aqueous phase was extracted with ethyl acetate (100 mL), the organic phase was washed with saturated brine (100 mL), dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 6-bromo-3,4-dihydro-2H-benzo[1,4]oxazine as a brown oil (2 g, quantitative yield). NMR hydrogen spectrum (DMSO-d6) δ: 3.36-3.44 (2H, multiple peaks), 3.81 (1H, broad single peak), 4.18-4.25 (2H, multiple peaks), 6.68 (3H, multiple peaks).
References
[1] Patent: WO2008/44022, 2008, A1. Location in patent: Page/Page column 29
[2] Patent: WO2008/47109, 2008, A1. Location in patent: Page/Page column 50-51
[3] Patent: WO2009/71895, 2009, A1. Location in patent: Page/Page column 97-98
[4] Patent: WO2009/71888, 2009, A1. Location in patent: Page/Page column 73
[5] Patent: WO2009/71890, 2009, A1. Location in patent: Page/Page column 103-104
6-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
6-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride Suppliers
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View Lastest Price from 6-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride manufacturers
- Product
- 6-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride 105655-01-4
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-09