ChemicalBook > CAS DataBase List > 6-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride

6-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride

Product Name: 6-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride
CAS No.: 105655-01-4
Chemical Name: 6-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride
Synonyms: 6-Bromo-3,4-dihydro-2H-1,4-benzoxazine;6-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine;2H-1,4-Benzoxazine, 6-bromo-3,4-dihydro-;6-Bromo-3,4-dihydro-2H-1,4-benzoxazine,97%;6-bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine;6-BroMo-3,4-dihydro-2H-benzo[b][1,4]oxazine HCl;6-BROMO-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE;6-Bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine
CBNumber: CB8850760
Molecular Formula: C8H8BrNO
Formula Weight: 214.06
MOL File: 105655-01-4.mol

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6-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride Property

Boiling point:: 296.4±40.0 °C(Predicted)
Density: 1.534±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: solid
pka: 3.59±0.20(Predicted)
Appearance: Light brown to orange Solid-liquid mixture
InChI: InChI=1S/C8H8BrNO/c9-6-1-2-8-7(5-6)10-3-4-11-8/h1-2,5,10H,3-4H2
InChIKey: RWKBNMSHIJBNAO-UHFFFAOYSA-N
SMILES: O1C2=CC=C(Br)C=C2NCC1

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Safety

Hazard Codes: Xn
Risk Statements: 22
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: VBP00109
Product name: 6-Bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine
Packaging: 1g
Price: $497
Updated: 2025/07/31

TRC

Product number: B683535
Product name: 6-Bromo-3,4-dihydro-2H-1,4-benzoxazine
Packaging: 250mg
Price: $70
Updated: 2021/12/16

TRC

Product number: B683535
Product name: 6-Bromo-3,4-dihydro-2H-1,4-benzoxazine
Packaging: 2.5g
Price: $220
Updated: 2021/12/16

Matrix Scientific

Product number: 131801
Product name: 6-Bromo-3,4-dihydro-2H-benzo-[b][1,4]oxazinehydrochloride
Purity: 97%
Packaging: 25g
Price: $3592
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0410301
Product name: 6-BROMO-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE
Purity: 95.00%
Packaging: 5G
Price: $3811.5
Updated: 2021/12/16

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6-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride Chemical Properties,Usage,Production

Uses

6-Bromo-3,4-dihydro-2H-1,4-benzoxazine is a reactant used for the synthesis of N-dichloroacetyl-3,4-dihydro-2H-1,4-benzoxazine derivatives.

Synthesis

24036-52-0

105655-01-4

General procedure for the synthesis of 6-bromo-3,4-dihydro-2H-benzo[1,4]oxazines from 6-bromo-2H-1,4-benzoxazin-3(4H)-ones: at room temperature, the borane-tetrahydrofuran complex (13.2 mL of a 1 M solution of tetrahydrofuran, 13.2 mmol) was added batchwise to intermediate 6 (2.0 g, 8.0 mmol) in a tetrahydrofuran ( 50 mL) solution. The reaction mixture was stirred for 10 minutes at room temperature and then heated to reflux for 1 hour, followed by cooling to room temperature. The reaction mixture was cooled in an ice bath and the reaction was quenched sequentially with water (20 mL) and 2 N aqueous sodium hydroxide solution (20 mL). The solvent was removed by rotary evaporator and the resulting mixture was diluted with water (100 mL). The aqueous phase was extracted with ethyl acetate (100 mL), the organic phase was washed with saturated brine (100 mL), dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 6-bromo-3,4-dihydro-2H-benzo[1,4]oxazine as a brown oil (2 g, quantitative yield). NMR hydrogen spectrum (DMSO-d6) δ: 3.36-3.44 (2H, multiple peaks), 3.81 (1H, broad single peak), 4.18-4.25 (2H, multiple peaks), 6.68 (3H, multiple peaks).

References

[1] Patent: WO2008/44022, 2008, A1. Location in patent: Page/Page column 29
[2] Patent: WO2008/47109, 2008, A1. Location in patent: Page/Page column 50-51
[3] Patent: WO2009/71895, 2009, A1. Location in patent: Page/Page column 97-98
[4] Patent: WO2009/71888, 2009, A1. Location in patent: Page/Page column 73
[5] Patent: WO2009/71890, 2009, A1. Location in patent: Page/Page column 103-104

6-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 6-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride manufacturers

Career Henan Chemical Co

Product: 6-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride 105655-01-4
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-09

105655-01-4, 6-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine hydrochlorideRelated Search:

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105655-01-4