Ampiroxicam
- Product Name
- Ampiroxicam
- CAS No.
- 99464-64-9
- Chemical Name
- Ampiroxicam
- Synonyms
- Nasil;Flucam;CP 65703;Ampiroam;AMPIROXICAM;Ampiroxicam(CP 65703);Ampiroxicam USP/EP/BP;99464-64-9 Ampiroxicam;AMPICILLINTRIHYDRATEPOWDER;iazin-4-yl)oxy)ethylester,s,s-dioxide
- CBNumber
- CB1461705
- Molecular Formula
- C20H21N3O7S
- Formula Weight
- 447.46
- MOL File
- 99464-64-9.mol
Ampiroxicam Property
- Melting point:
- 159-161?C
- Density
- 1.44±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 12.74±0.20(Predicted)
- color
- White to Off-White
- CAS DataBase Reference
- 99464-64-9(CAS DataBase Reference)
Safety
- Toxicity
- LD50 orally in male, female rats: 1798, 747 mg/kg (Iijima)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 23026
- Product name
- Ampiroxicam
- Purity
- ≥98%
- Packaging
- 500mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 23026
- Product name
- Ampiroxicam
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $84
- Updated
- 2024/03/01
- Product number
- 23026
- Product name
- Ampiroxicam
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $193
- Updated
- 2024/03/01
- Product number
- 23026
- Product name
- Ampiroxicam
- Purity
- ≥98%
- Packaging
- 10g
- Price
- $341
- Updated
- 2024/03/01
- Product number
- 002659
- Product name
- Ampiroxicam
- Packaging
- 10mg
- Price
- $403
- Updated
- 2021/12/16
Ampiroxicam Chemical Properties,Usage,Production
Description
Ampiroxicam is a once-daily non-steroidal anti-inflammatory drug (NSAID) introduced in Japan. As a non-acidic ether carbonate prodrug of the widely used antiinflammatory agent, piroxicam, ampiroxicam is similar or more potent than piroxicam in suppressing carrageenan edema, ultraviolet erythema, traumatic edema, capillary permeability, acetic acid writhing, yeast algesia and yeast hyperthermia in many animals. Eioavailability studies in man show undetectable plasma levels of ampiroxicam indicating 100% conversion to piroxicam during absorption process. Ampiroxicam has been reported to have fewer side effects on the gastric mucosa than piroxicam.
Chemical Properties
White Solid
Originator
Pflzer (Japan)
Uses
Prodrug of Piroxicam. Anti-inflammatory.
Uses
antiinflammatory, analgesic
Definition
ChEBI: A benzothiazine that is the 1-[(ethoxycarbonyl)oxy]ethyl ether of piroxicam. A prodrug for piroxicam, it is used for the relief of pain and inflammation in musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis.
Manufacturing Process
To a round bottomed flask equipped with a reflux condenser and stirring bar were added 2-methyl-N-(2-pyridyl)-4-hydroxy-2H-1,2-benzodiazine-3- carboxamide 1,1-dioxide (piroxicam, 10.0 g, 30.2 mmol), potassium carbonate (8.35 g, 60.4 mmol), α-chloroethyl ethyl carbonate (12.35 mL, 13.81 g, 90.6 mmol) and acetone (350 mL). The heterogenous reaction mixture was heated to reflux under a nitrogen atmosphere. After 19 hours, anhydrous sodium iodide (22.6 g, 150.7 mmol) was added and reflux continued for an additional 5 hours. The acetone was removed in vacuum leaving a brown residue which was treated with water (250 mL) and methylene chloride (250 mL). The organic layer was separated and the aqueous layer extracted with additional methylene chloride (250 mL). The combined organic extracts were washed with water (250 mL), brine (250 mL), dried (Na2SO4) and concentrated in vacuum to a brown oil. Column chromatography on silica gel (1:9 ethyl acetate:methylene chloride) afforded a pale yellow foam (10.67 g, 79.0%). The 4-[1-(ethoxycarbonyloxy)ethoxy]- 2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide was recrystallized from toluene to give 9.50 g of pure white crystals; melting point 159-161°C.
brand name
Nacyl; Flucam
Therapeutic Function
Antiinflammatory
Ampiroxicam Preparation Products And Raw materials
Raw materials
Preparation Products
Ampiroxicam Suppliers
View Lastest Price from Ampiroxicam manufacturers
- Product
- Ampiroxicam 99464-64-9
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100 tons
- Release date
- 2023-04-17
- Product
- Ampiroxicam 99464-64-9
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-04-29
- Product
- Ampiroxicam 99464-64-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10