Ampiroxicam

ChemicalBook > CAS DataBase List > Ampiroxicam

Product Name: Ampiroxicam
CAS No.: 99464-64-9
Chemical Name: Ampiroxicam
Synonyms: Nasil;Flucam;CP 65703;Ampiroam;AMPIROXICAM;Ampiroxicam(CP 65703);Ampiroxicam USP/EP/BP;99464-64-9 Ampiroxicam;AMPICILLINTRIHYDRATEPOWDER;iazin-4-yl)oxy)ethylester,s,s-dioxide
CBNumber: CB1461705
Molecular Formula: C20H21N3O7S
Formula Weight: 447.46
MOL File: 99464-64-9.mol

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Ampiroxicam Property

Melting point:: 159-161?C
Density: 1.44±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 12.74±0.20(Predicted)
color: White to Off-White
CAS DataBase Reference: 99464-64-9(CAS DataBase Reference)

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Safety

Toxicity: LD50 orally in male, female rats: 1798, 747 mg/kg (Iijima)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23026
Product name: Ampiroxicam
Purity: ≥98%
Packaging: 500mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 23026
Product name: Ampiroxicam
Purity: ≥98%
Packaging: 1g
Price: $84
Updated: 2024/03/01

Cayman Chemical

Product number: 23026
Product name: Ampiroxicam
Purity: ≥98%
Packaging: 5g
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 23026
Product name: Ampiroxicam
Purity: ≥98%
Packaging: 10g
Price: $341
Updated: 2024/03/01

Usbiological

Product number: 002659
Product name: Ampiroxicam
Packaging: 10mg
Price: $403
Updated: 2021/12/16

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Ampiroxicam Chemical Properties,Usage,Production

Description

Ampiroxicam is a once-daily non-steroidal anti-inflammatory drug (NSAID) introduced in Japan. As a non-acidic ether carbonate prodrug of the widely used antiinflammatory agent, piroxicam, ampiroxicam is similar or more potent than piroxicam in suppressing carrageenan edema, ultraviolet erythema, traumatic edema, capillary permeability, acetic acid writhing, yeast algesia and yeast hyperthermia in many animals. Eioavailability studies in man show undetectable plasma levels of ampiroxicam indicating 100% conversion to piroxicam during absorption process. Ampiroxicam has been reported to have fewer side effects on the gastric mucosa than piroxicam.

Chemical Properties

White Solid

Originator

Pflzer (Japan)

Uses

Prodrug of Piroxicam. Anti-inflammatory.

Uses

antiinflammatory, analgesic

Definition

ChEBI: A benzothiazine that is the 1-[(ethoxycarbonyl)oxy]ethyl ether of piroxicam. A prodrug for piroxicam, it is used for the relief of pain and inflammation in musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis.

Manufacturing Process

To a round bottomed flask equipped with a reflux condenser and stirring bar were added 2-methyl-N-(2-pyridyl)-4-hydroxy-2H-1,2-benzodiazine-3- carboxamide 1,1-dioxide (piroxicam, 10.0 g, 30.2 mmol), potassium carbonate (8.35 g, 60.4 mmol), α-chloroethyl ethyl carbonate (12.35 mL, 13.81 g, 90.6 mmol) and acetone (350 mL). The heterogenous reaction mixture was heated to reflux under a nitrogen atmosphere. After 19 hours, anhydrous sodium iodide (22.6 g, 150.7 mmol) was added and reflux continued for an additional 5 hours. The acetone was removed in vacuum leaving a brown residue which was treated with water (250 mL) and methylene chloride (250 mL). The organic layer was separated and the aqueous layer extracted with additional methylene chloride (250 mL). The combined organic extracts were washed with water (250 mL), brine (250 mL), dried (Na2SO4) and concentrated in vacuum to a brown oil. Column chromatography on silica gel (1:9 ethyl acetate:methylene chloride) afforded a pale yellow foam (10.67 g, 79.0%). The 4-[1-(ethoxycarbonyloxy)ethoxy]- 2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide was recrystallized from toluene to give 9.50 g of pure white crystals; melting point 159-161°C.

brand name

Nacyl; Flucam

Therapeutic Function

Antiinflammatory

Ampiroxicam Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ampiroxicam manufacturers

Hebei Duling International Trade Co. LTD

Product: Ampiroxicam 99464-64-9
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100 tons
Release date: 2023-04-17

Shaanxi Dideu Medichem Co. Ltd

Product: Ampiroxicam 99464-64-9
Price: US $1.00-1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-04-29

Zhuozhou Wenxi import and Export Co., Ltd

Product: Ampiroxicam 99464-64-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

99464-64-9, AmpiroxicamRelated Search:

Basic Violet 1 Methyl acrylate Chlorantraniliprole Methyl acetate Paraquat dichloride Methylparaben N,N-Dimethylformamide Acetonitrile Methanol Benzamide Kresoxim-methyl Formamide,Deionized Formamide Piroxicam Methyl Meloxicam Tenoxicam Lornoxicam

4-[1-(ethoxycarbonyloxy)ethoxy]-2-methyl-n-(2-pyridyl)-2h-1,2-benzothiazine-3-carboxamide-1,1-dioxide

AMPIROXICAM

2H-1,2-Benzothiazine, carbonic acid deriv.

Carbonic acid, ethyl 1-[[2-methyl-1,1-dioxido-3-[(2-pyridinylamino)carbonyl]-2H-1,2-benzothiazin-4-yl]oxy]ethyl ester

Carbonic acid, ethyl 1-[[2-methyl-3-[(2-pyridinylamino)carbonyl]-2H-1,2-benzothiazin-4-yl]oxy]ethyl ester, S,S-dioxide

CP 65703

Flucam

Nasil

AMPICILLINTRIHYDRATEPOWDER

carbonicacid,ethyl1-((2-methyl-3-((2-pyridinylamino)carbonyl)-2h-1,2-benzoth

iazin-4-yl)oxy)ethylester,s,s-dioxide

4-(1-Acetyloxyethoxy)-3-[[(2-pyridinyl)amino]carbonyl]-2-methyl-2H-1,2-benzothiazine 1,1-dioxide

Ampiroam

4-[1-(Ethoxycarbonyloxy)ethoxy]-2-methyl-N-(pyridin-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-Dioxide

CP65703;FLUCAM;NASIL;CP 65703;CP-65703

3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]oct-3-ene-4-carboxylic acid methyl ester

Ampiroxicam(CP 65703)

ethyl 1-{[2-methyl-1,1-dioxido-3-(pyridin-2-ylcarbamoyl)-2h-1,2-benzothiazin-4-yl]oxy}ethyl carbonate

Ampiroxicam USP/EP/BP

AmpiroxicamQ: What is Ampiroxicam Q: What is the CAS Number of Ampiroxicam Q: What is the storage condition of Ampiroxicam Q: What are the applications of Ampiroxicam

99464-64-9 Ampiroxicam

Ethyl (1-((2-methyl-1,1-dioxido-3-(pyridin-2-ylcarbamoyl)-2H-benzo[e][1,2]thiazin-4-yl)oxy)ethyl) carbonate

99464-64-9

C20H21N3O7S

API

FLUCAM

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