PLX3397 HCl

Product Name: PLX3397 HCl
CAS No.: 2040295-03-0
Chemical Name: PLX3397 HCl
Synonyms: PLX3397 HCl;Pexidartinib hcl;PLX-3397 hydrochloride;Pexidartinib Hydrochloride Salt;Pexidartinib hydrochloride (PLX-3397);Pexidartinib hydrochloride, PLX-3397 HCl;Pexidartinib hydrochloride (PLX-3397 hydrochloride);5-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine hydrochloride
CBNumber: CB14662614
Molecular Formula: C20H16Cl2F3N5
Formula Weight: 454.28
MOL File: 2040295-03-0.mol

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PLX3397 HCl Property

storage temp.: Store at -20°C
solubility: DMSO:60.0(Max Conc. mg/mL);132.1(Max Conc. mM)
form: Solid
color: White to off-white
InChIKey: CJLUYLRKLUYCEK-UHFFFAOYSA-N
SMILES: C(C1=CN=C(NCC2=CN=C(C(F)(F)F)C=C2)C=C1)C1=CNC2=NC=C(Cl)C=C12.Cl

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: P293640
Product name: PexidartinibHydrochlorideSalt
Packaging: 250mg
Price: $1540
Updated: 2021/12/16

ChemScene

Product number: CS-0092634
Product name: Pexidartinib(hydrochloride)
Purity: 99.95%
Packaging: 10mg
Price: $70
Updated: 2021/12/16

ChemScene

Product number: CS-0092634
Product name: Pexidartinib(hydrochloride)
Purity: 99.95%
Packaging: 50mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0092634
Product name: Pexidartinib(hydrochloride)
Purity: 99.95%
Packaging: 200mg
Price: $260
Updated: 2021/12/16

ChemScene

Product number: CS-0092634
Product name: Pexidartinib(hydrochloride)
Purity: 99.95%
Packaging: 1g
Price: $750
Updated: 2021/12/16

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PLX3397 HCl Chemical Properties,Usage,Production

Uses

Pexidartinib Hydrochloride is RTK inhibitor. It can be used in pharmacological activity, therapeutic use, and biological study of inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition.

in vivo

Pexidartinib can be used to deplete the microglia cells in mice.
Pexidartinib (290 ppm in AIN-76A standard chow, 21 days) depletes the microglia cells in brain by 70% in adult male C57BL/6?J mice (20–25?g)^[5].
Pexidartinib (600 ppm in chow, 10 days and 30 days ) depletes the microglia cells more than 90% in brain of C57BL/6J mice^[6].
Pexidartinib hydrochloride (0.25, 1 mg/kg, i.p., twice daily for 8 days) inhibits the proliferation of microglia and BrdU-positive cells in neonatal mice^[2].
Pexidartinib hydrochloride (1 mg/kg, twice daily for 8 day) shows no obvious effect on the cleaved caspase-3-positive cells in mice^[2].
Pexidartinib hydrochloride (50 mg/kg; p.o.; every second day for 3 weeks) reduces tissue macrophage levels without affecting glucose homeostasis in mice^[4].

Animal Model:	Neonatal mice^[2]
Dosage:	0.25, 1 mg/kg
Administration:	I.P. twice daily for 8 days
Result:	Decreased the number of microglia and BrdU-positive proliferative cells, but did not change the cleaved caspase-3-positive cells.

Animal Model:	10-week old litter mate C57BL/6 mice (chow and high-fat diet fed mice)^[4]
Dosage:	50?mg/kg
Administration:	P.o.; every second day for 3 weeks
Result:	Substantially reduced macrophage numbers in adipose tissue of both chow and high-fat diet fed mice without affecting total myeloid cell levels.

PLX3397 HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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PLX3397 HCl Suppliers

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Pexidartinib hydrochloride (PLX-3397 hydrochloride)

5-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine hydrochloride

2040295-03-0

C20H16Cl2F3N5

API