PLX5622
- Product Name
- PLX5622
- CAS No.
- 1303420-67-8
- Chemical Name
- PLX5622
- Synonyms
- PLX5622;PLX 5622;PLX-5622;PLX5622 USP/EP/BP;6-Fluoro-N-[(5-fluoro-2-methoxy-3-pyridyl)methyl]-5-[(5-methyl-7-azaindole-3-yl)methyl]pyridin-2-amine;5-Fluoro-N-[6-fluoro-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-2-methoxy-3-pyridinemethanamine;6-FLUORO-N-((5-FLUORO-2-METHOXYPYRIDIN-3-YL)METHYL)-5-((5-METHYL-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)METHYL)PYRIDIN-2-AMINE;3-Pyridinemethanamine, 5-fluoro-N-[6-fluoro-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-2-methoxy-;PLX5622,PLX 5622,Inhibitor,CSF-1 receptor,microglial,CSF1R,orally,pathology,inhibit,c-Fms,penetrant,preceding,brain,colony stimulating factor 1 receptor,CSF-1R,elimination
- CBNumber
- CB15476531
- Molecular Formula
- C21H19F2N5O
- Formula Weight
- 395.41
- MOL File
- 1303420-67-8.mol
PLX5622 Property
- Density
- 1.364±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (>25 mg/ml)
- form
- solid
- pka
- 13?+-.0.40(Predicted)
- color
- Pale yellow
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 28927
- Product name
- PLX5622
- Packaging
- 1mg
- Price
- $26
- Updated
- 2024/03/01
- Product number
- 28927
- Product name
- PLX5622
- Packaging
- 25mg
- Price
- $275
- Updated
- 2024/03/01
- Product number
- 28927
- Product name
- PLX5622
- Packaging
- 5mg
- Price
- $106
- Updated
- 2024/03/01
- Product number
- 28927
- Product name
- PLX5622
- Packaging
- 10mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- CS-0077157
- Product name
- PLX5622
- Purity
- 99.86%
- Packaging
- 10mg
- Price
- $195
- Updated
- 2021/12/16
PLX5622 Chemical Properties,Usage,Production
Description
PLX5622 (1303420-67-8) is a highly selective (>20 fold over KIT and FLT3, >60 fold over 200 other kinases) and brain-penetrant inhibitor of colony-stimulating factor 1 receptor (CSF1R; IC50 = 16 nM).1 It prevented plaque formation in 5xFAD1 and 3xTg2 mouse models of Alzheimer’s disease via elimination of microglia in a CSF1R-dependent manner.? PLX5622 showed efficacy in a mouse neuropathic pain model via reduction of CD86+ macrophages resulting in reduced expression of pro-inflammatory cytokines.3 It also was able to ameliorate peripheral neuropathy in aging mice.4 PLX5622 displayed neuroprotective effects during the chronic phase of a traumatic brain injury mouse model.5? PLX5622 has also been shown to affect myeloid and lymphoid compartments, indicating that its affects are not limited to microglia and include peripheral immune cells.6
References
Spangenberg et al. (2019) Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model; Nat. Commun.?10 3758 Dagher et al. (2015) Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice; J.? Neuroinflammation 12 139 Lee et al. (2018) Targeting macrophage and microglia activation with colony stimulating factor 1 receptor inhibitor is an effective strategy to treat injury-triggered neuropathic pain; Mol.? Pain?14 1 Yaun et al. (2018) Macrophage Depletion Ameliorates Peripheral Neuropathy in Aging Mice.; J.? Neurosci.?38 4610 Henry et al. (2020) Microglial Depletion with CSF1R Inhibitor During Chronic Phase of Experimental Traumatic Brain Injury Reduces Neurodegeneration and Neurological Deficits.; J.? Neurosci.?40 2960 Lei et al. (2020) CSF1R inhibition by a small-molecule inhibitor is not microglia specific; affecting hematopoiesis and the function of macrophages.; Proc. ?Natl. Acad. Sci USA?117 23336
PLX5622 Preparation Products And Raw materials
Raw materials
Preparation Products
PLX5622 Suppliers
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
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- 4512
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- 55
- Tel
- 18164002430
- 511710754@qq.com
- Country
- China
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- 228
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- 58
- Tel
- 13606124132;13656121842
- luyan0021@163.com
- Country
- China
- ProdList
- 219
- Advantage
- 58
- Tel
- 0550-5196001 15000891977
- Fax
- 0550-5196001
- wj520wjxby@126.com
- Country
- China
- ProdList
- 1847
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- 55
- Tel
- 17316404525
- 209533805@qq.com
- Country
- China
- ProdList
- 9762
- Advantage
- 58
- Tel
- 177-54423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8011
- Advantage
- 62
- Tel
- 13823398779 18670069958
- 3062105966@qq.com
- Country
- China
- ProdList
- 3262
- Advantage
- 58
- Tel
- 17752881701
- 190060276@qq.com
- Country
- China
- ProdList
- 111
- Advantage
- 58
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 19172
- Advantage
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- Tel
- 0411-62910999 13889544652
- meilunui@163.com
- Country
- China
- ProdList
- 4727
- Advantage
- 58
View Lastest Price from PLX5622 manufacturers
- Product
- PLX5622 1303420-67-8
- Price
- US $150.00-150.00/KG
- Min. Order
- 1KG
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2023-10-07
- Product
- PLX5622 1303420-67-8
- Price
- US $2900.00-22118.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2023-05-22
- Product
- PLX5622 1303420-67-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-17