CFM 4
- Product Name
- CFM 4
- CAS No.
- 331458-02-7
- Chemical Name
- CFM 4
- Synonyms
- CFM 4;CFM-4, CARP-1 mimetic;1-[(2-Chlorophenyl)methyl]-5'-phenyl-spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one;Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 1-[(2-chlorophenyl)methyl]-5'-phenyl-
- CBNumber
- CB14718599
- Molecular Formula
- C22H16ClN3OS
- Formula Weight
- 405.9
- MOL File
- 331458-02-7.mol
CFM 4 Property
- Boiling point:
- 653.4±65.0 °C(Predicted)
- Density
- 1.39±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (greater than 25 mg/ml)
- form
- solid
- pka
- 0.13±0.20(Predicted)
- color
- Tan
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
N-Bromosuccinimide Price
- Product number
- 5144
- Product name
- CFM4
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $156
- Updated
- 2021/12/16
- Product number
- 5144
- Product name
- CFM4
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $648
- Updated
- 2021/12/16
- Product number
- C291738
- Product name
- CFM4
- Packaging
- 5mg
- Price
- $385
- Updated
- 2021/12/16
- Product number
- 254924
- Product name
- CFM 4
- Packaging
- 10mg
- Price
- $452
- Updated
- 2021/12/16
- Product number
- B7760
- Product name
- CFM4
- Packaging
- 10mg
- Price
- $308
- Updated
- 2021/12/16
CFM 4 Chemical Properties,Usage,Production
Description
CFM-4 (331458-02-7) is a CARP-1 functional mimetic that interferes with CARP-1 binding to APC-2 (IC50=10-15 μM).1 Enhances CARP-1 expression and induces G2/M cell cycle arrest. Induces apoptosis and suppresses growth of medulloblastoma cells2 and malignant pleural mesothelioma cells3.
Uses
CFM-4 is a potent small molecular antagonist of CARP-1/APC-2 binding. CFM-4 prevents CARP-1 binding with APC-2, causes G2M cell cycle arrest, and induces apoptosis with an IC50 range of 10-15 μM. CFM-4 also suppresses growth of drug-resistant human breast cancer cells[1].
References
[1] VINESHKUMAR THIDIL PULIYAPPADAMBA. Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis.[J]. The Journal of Biological Chemistry, 2011: 38000-38017. DOI:10.1074/jbc.m111.222398
[2] ABDELKADER E ASHOUR. CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth.[J]. PLoS ONE, 2013: e66733. DOI:10.1371/journal.pone.0066733
[3] SHAZIA JAMAL. CARP-1 functional mimetics are a novel class of small molecule inhibitors of malignant pleural mesothelioma cells.[J]. PLoS ONE, 2014: e89146. DOI:10.1371/journal.pone.0089146
CFM 4 Preparation Products And Raw materials
Raw materials
Preparation Products
CFM 4 Suppliers
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 15076683720
- Fax
- 022-23754520
- klq@cw-bio.com
- Country
- China
- ProdList
- 8011
- Advantage
- 55
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8140
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24961
- Advantage
- 58
- Tel
- 021-65675885 18964387627
- customer_service@efebio.com
- Country
- China
- ProdList
- 11973
- Advantage
- 58
- Tel
- 400-6206333 13167063860
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 48457
- Advantage
- 58
- Tel
- 025-58851090 17714375163
- 2881759498@qq.com
- Country
- China
- ProdList
- 13011
- Advantage
- 58
- Tel
- 400-821-026
- Sales@sangon.com
- Country
- China
- ProdList
- 6710
- Advantage
- 58
- Tel
- 800-364-9897
- sales@caymanchem.com
- Country
- China
- ProdList
- 6838
- Advantage
- 58