ChemicalBook > CAS DataBase List > CFM 4

CFM 4

Product Name
CFM 4
CAS No.
331458-02-7
Chemical Name
CFM 4
Synonyms
CFM 4;1-[(2-Chlorophenyl)methyl]-5'-phenyl-spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one;Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 1-[(2-chlorophenyl)methyl]-5'-phenyl-
CBNumber
CB14718599
Molecular Formula
C22H16ClN3OS
Formula Weight
405.9
MOL File
331458-02-7.mol
More
Less

CFM 4 Property

Boiling point:
653.4±65.0 °C(Predicted)
Density 
1.39±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO (greater than 25 mg/ml)
form 
solid
pka
0.13±0.20(Predicted)
color 
Tan
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Tocris
Product number
5144
Product name
CFM4
Purity
≥99%(HPLC)
Packaging
10
Price
$156
Updated
2021/12/16
Tocris
Product number
5144
Product name
CFM4
Purity
≥99%(HPLC)
Packaging
50
Price
$648
Updated
2021/12/16
TRC
Product number
C291738
Product name
CFM4
Packaging
5mg
Price
$385
Updated
2021/12/16
Usbiological
Product number
254924
Product name
CFM 4
Packaging
10mg
Price
$452
Updated
2021/12/16
ApexBio Technology
Product number
B7760
Product name
CFM4
Packaging
10mg
Price
$308
Updated
2021/12/16
More
Less

CFM 4 Chemical Properties,Usage,Production

Description

CFM-4 (331458-02-7) is a CARP-1 functional mimetic that interferes with CARP-1 binding to APC-2 (IC50=10-15 μM).1 Enhances CARP-1 expression and induces G2/M cell cycle arrest. Induces apoptosis and suppresses growth of medulloblastoma cells2 and malignant pleural mesothelioma cells3.

References

1) Puliyappadamba et al. (2011), Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis; J. Biol. Chem. 286 38000 2) Ashour et al. (2013), CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth; PLoS ONE 8 e66733 3) Jamal et al. (2014), CARP-1 functional mimetics are a novel class of small molecule inhibitors of malignant pleural mesothelioma cells; PLoS ONE 9 e89146

CFM 4 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

CFM 4 Suppliers

Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
4601
Advantage
55
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24647
Advantage
58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11974
Advantage
58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
+86-18521732826
Email
market@aladdin-e.com
Country
China
ProdList
48461
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58

331458-02-7, CFM 4Related Search:


  • CFM 4
  • 1-[(2-Chlorophenyl)methyl]-5'-phenyl-spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one
  • Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 1-[(2-chlorophenyl)methyl]-5'-phenyl-
  • 331458-02-7