CFM 4
- Product Name
- CFM 4
- CAS No.
- 331458-02-7
- Chemical Name
- CFM 4
- Synonyms
- CFM 4;1-[(2-Chlorophenyl)methyl]-5'-phenyl-spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one;Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 1-[(2-chlorophenyl)methyl]-5'-phenyl-
- CBNumber
- CB14718599
- Molecular Formula
- C22H16ClN3OS
- Formula Weight
- 405.9
- MOL File
- 331458-02-7.mol
CFM 4 Property
- Boiling point:
- 653.4±65.0 °C(Predicted)
- Density
- 1.39±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (greater than 25 mg/ml)
- form
- solid
- pka
- 0.13±0.20(Predicted)
- color
- Tan
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
N-Bromosuccinimide Price
- Product number
- 5144
- Product name
- CFM4
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $156
- Updated
- 2021/12/16
- Product number
- 5144
- Product name
- CFM4
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $648
- Updated
- 2021/12/16
- Product number
- C291738
- Product name
- CFM4
- Packaging
- 5mg
- Price
- $385
- Updated
- 2021/12/16
- Product number
- 254924
- Product name
- CFM 4
- Packaging
- 10mg
- Price
- $452
- Updated
- 2021/12/16
- Product number
- B7760
- Product name
- CFM4
- Packaging
- 10mg
- Price
- $308
- Updated
- 2021/12/16
CFM 4 Chemical Properties,Usage,Production
Description
CFM-4 (331458-02-7) is a CARP-1 functional mimetic that interferes with CARP-1 binding to APC-2 (IC50=10-15 μM).1 Enhances CARP-1 expression and induces G2/M cell cycle arrest. Induces apoptosis and suppresses growth of medulloblastoma cells2 and malignant pleural mesothelioma cells3.
References
1) Puliyappadamba et al. (2011), Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis; J. Biol. Chem. 286 38000 2) Ashour et al. (2013), CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth; PLoS ONE 8 e66733 3) Jamal et al. (2014), CARP-1 functional mimetics are a novel class of small molecule inhibitors of malignant pleural mesothelioma cells; PLoS ONE 9 e89146
CFM 4 Preparation Products And Raw materials
Raw materials
Preparation Products
CFM 4 Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77