ChemicalBook > CAS DataBase List > 6-HYDROXY-7-METHOXYCOUMARIN

6-HYDROXY-7-METHOXYCOUMARIN

Product Name
6-HYDROXY-7-METHOXYCOUMARIN
CAS No.
776-86-3
Chemical Name
6-HYDROXY-7-METHOXYCOUMARIN
Synonyms
ISOSCOPOLETIN;ISOSCOPOLETINE;Isoscopolamine;7-Methoxyesculetin;6-O-Demethylscoparone;esculetin 7-methyl ether;6-HYDROXY-7-METHYLCOUMARIN;6-HYDROXY-7-METHOXYCOUMARIN;7-METHOXY-6-HYDROXYCOUMARIN;6-hudroxy-7-methoxycoumarin
CBNumber
CB1472785
Molecular Formula
C10H8O4
Formula Weight
192.17
MOL File
776-86-3.mol
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6-HYDROXY-7-METHOXYCOUMARIN Property

Melting point:
206-208°C
Boiling point:
413.5±45.0 °C(Predicted)
Density 
1.37 g/cm3
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO: soluble
pka
8.94±0.20(Predicted)
form 
Solid
color 
Pale Beige to Light Beige
LogP
0.830 (est)
CAS DataBase Reference
776-86-3
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Safety

Hazard Codes 
Xi
Risk Statements 
22-36/37/38
Safety Statements 
22-24/25-36-26
WGK Germany 
3
F 
8
HS Code 
29322090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL85752
Product name
Isoscopoletin
Purity
phyproof? Reference Substance
Packaging
20MG
Price
$344
Updated
2024/03/01
TRC
Product number
H517345
Product name
6-Hydroxy-7-methoxycoumarin
Packaging
2.5mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FI67110
Product name
Isoscopoletin
Packaging
10mg
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
FI67110
Product name
Isoscopoletin
Packaging
25mg
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FI67110
Product name
Isoscopoletin
Packaging
50mg
Price
$100
Updated
2021/12/16
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6-HYDROXY-7-METHOXYCOUMARIN Chemical Properties,Usage,Production

Description

Isoscopolamine is an antiasthmatic drug, which has the effect of relaxing smooth muscle and antihistamine. It can be used clinically in patients with chronic bronchitis and bronchial asthma.

Chemical Properties

Yellow needle-like crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from Dengzhanhua, Rhododendron.

Uses

Isoscopolamine has anti-inflammatory, antioxidant, improving myocardial ischemia, anti-arrhythmic effects.

Definition

ChEBI: Isoscopoletin is a hydroxycoumarin that is esculetin in which the hydroxy group at position 7 is replaced by a methoxy group. It is the major primary metabolite of scoparone. It has a role as a plant metabolite. It is a hydroxycoumarin and an aromatic ether. It is functionally related to an esculetin.

Biological Activity

Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active ingredient in Artemisia argyi. It has a significant inhibitory effect on cell proliferation with IC50 values of 4.0 μM and 1.6 μM against human CCRF-CEM leukemia cells and drug-resistant subline CEM/ADR5000, respectively. It (6-Hydroxy-7-methoxycoumarin) has the activity of inhibiting HBV replication.

6-HYDROXY-7-METHOXYCOUMARIN Preparation Products And Raw materials

Raw materials

Isovanillin Acetic anhydride Sodium acetate trihydrate Ammonium persulfate Ethyl acetate PETROLEUM ETHER

Preparation Products

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6-HYDROXY-7-METHOXYCOUMARIN Suppliers

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View Lastest Price from 6-HYDROXY-7-METHOXYCOUMARIN manufacturers

Shanghai Standard Technology Co., Ltd.
Product
Isoscopoletin 776-86-3
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-09-27
Dideu Industries Group Limited
Product
6-HYDROXY-7-METHOXYCOUMARIN 776-86-3
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-05-28
Shaanxi Dideu Medichem Co. Ltd
Product
6-Hydroxy-7-methoxycoumarin 776-86-3
Price
US $0.01-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50 tons
Release date
2020-04-24

776-86-3, 6-HYDROXY-7-METHOXYCOUMARINRelated Search:

Isoengelitin Fluorescein isothiocyanate isomer I Isocarapanaubine (3β,20α)-17α-Hydroxyyohimban-16β-carboxylic acid methyl ester Iso Altenuene ISOPULEGOL, TECH. 2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxy-2-methoxyphenyl)-8-[5-methyl-2-(1-methylvinyl)-4-hexenyl]-4H-1-benzopyran-4-one Isocoronarin D IsoMangiferolic acid 2″-O-α-L-Rhamnopyranosyl-isovitexin H-ILE-TYR-OH Isosalicifolin 5-PROPENYL-1,2,3-TRIMETHOXY Isoeleutherin ISOVITEXIN Isodunnial IsochaMaejasMin ISOQUERCITRIN

  • 7-METHOXY-6-HYDROXYCOUMARIN
  • 6-HYDROXY-7-METHYLCOUMARIN
  • 6-HYDROXY-7-METHOXYCOUMARIN
  • ISOSCOPOLETIN
  • ISOSCOPOLETINE
  • 6-hydroxy-7-methoxy-2-benzopyrone
  • 6-Hydroxy-7-methyl coumarin-(Isoscopoletin) -
  • ISOSCOPOLETIN (6-HYDROXY-7-METHYLCOUMARIN)
  • 7-Methoxyesculetin, Esculetin 7-methyl ether, Isoscopoletin
  • 6-Hydroxy-7-methoxy-2H-1-benzopyran-2-one
  • 6-O-Demethylscoparone
  • 6-hydroxy-7-methoxy-chromen-2-one
  • 6-hydroxy-7-methoxychromen-2-one
  • 6-hydroxy-7-methoxy-2H-chromen-2-one
  • 7-Methoxyesculetin
  • esculetin 7-methyl ether
  • 6-hudroxy-7-methoxycoumarin
  • Isoscopoletin (6-Hydroxy-7-methoxycoumarin)
  • 2H-1-Benzopyran-2-one, 6-hydroxy-7-methoxy-
  • 6-HYDROXY-7-METHOXYCOUMARIN USP/EP/BP
  • 6-Hydroxy-7-methoxycoumarin (Isoscopoletine)
  • Isoscopolamine
  • 776-86-3
  • Cd0H9O4
  • Biochemicals and Reagents
  • BioChemical
  • Other Fluorescent Labels
  • Fluorescent Probes, Labels, Particles and Stains
  • Fluorescent Labels
  • reagent
  • standard substance
  • Coumarins