Ryanodine

Product Name: Ryanodine
CAS No.: 15662-33-6
Chemical Name: Ryanodine
Synonyms: Ryanex;ryania;RYANADOL;ryanexel;Ryanexcel;Ryanicide;RYANODINE;bonideryatox;ryaniapowder;Ryanodine,99%
CBNumber: CB1480087
Molecular Formula: C25H35NO9
Formula Weight: 493.55
MOL File: 15662-33-6.mol

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Ryanodine Property

alpha: D25 +26° (methanol)
Boiling point:: 586.95°C (rough estimate)
Density: 1.2805 (rough estimate)
refractive index: 1.6000 (estimate)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO: soluble10mg/mL, clear
form: White solid
Melting point:: 219-220 °C
pka: 10.66±0.70(Predicted)
color: white to beige
CAS DataBase Reference: 15662-33-6
EPA Substance Registry System: Ryanodine (15662-33-6)

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Safety

Hazard Codes: Xn,N
Risk Statements: 21/22-50/53
Safety Statements: 36/37-60-61
RIDADR: UN 3077 9/PG 3
RTECS: VM4025000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 559276
Product name: Ryanodine, High Purity - CAS 15662-33-6 - Calbiochem
Purity: Naturally occurring alkaloid that blocks the release of Ca2+ from the sarcoplasmic reticulum.
Packaging: 500μg
Price: $265
Updated: 2024/03/01

Tocris

Product number: 1329
Product name: Ryanodine
Purity: ≥98%(HPLC)
Packaging: 1
Price: $214
Updated: 2021/12/16

Usbiological

Product number: 256544
Product name: Ryanodine
Packaging: 1mg
Price: $466
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FR30087
Product name: Ryanodine
Packaging: 1mg
Price: $700
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FR30087
Product name: Ryanodine
Packaging: 2mg
Price: $1100
Updated: 2021/12/16

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Ryanodine Chemical Properties,Usage,Production

Description

Ryania insecticide is the ground stem wood of the tropical tree Ryania speciosa Vahl., and it contains over a dozen of several structurally related alkaloids. Nowadays, this botanical preparation is of minor importance, but one of its major ingredients, ryanodine, is a widely used pharmacological tool in studies of the calcium release channels in sarcoplasmic reticulum membranes of skeletal and cardiac muscle of both insects and mammals (11,12).

Chemical Properties

white to off-white solid

Uses

Ryanodine is a potent inhibitor of Ca2+ release from sarcoplasmic reticulum with potential application towards the treatment of huntingtons disease.

Uses

Insecticide.

Definition

ChEBI: An insecticide alkaloid isolated from South American plant Ryania speciosa.

Biological Activity

Potent inhibitor of Ca 2+ release from sarcoplasmic reticulum (IC 50 values are 10 and 2.8 nM in skeletal and cardiac muscle respectively).

storage

-20°C (desiccate)

References

Rogers et ai., J. Amer. Chem. Soc., 70, 3086 (1948)
Kelly, Whittingham, Wusner., Chem. Ind., 857 (1952)
Structure:
Wiesner, Valenta, Findlay., Tetrahedron Lett., 221 (1967)
Hollstein, Rapoport.,J. Amer. Chem. Soc., 90,3864 (1968)
Wong, Hollstein, Rapoport., ibid, 90, 3866 (1968)
Wiesner., Collect. Czech. Chem. Commun., 33, 2656 (1968)
Crystal structure:
Srivastava, Przybylska., Can. J. Chem., 46,795 (1968)

Ryanodine Preparation Products And Raw materials

Raw materials

Preparation Products

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Ryanodine Suppliers

China 74 France 1 Germany 2 India 1 Japan 3 Switzerland 3 United Kingdom 12 United States 22 Global 118

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15662-33-6, RyanodineRelated Search:

CYCLODODECYL FORMATE CYCLODODECANE CYCLOOCTANEMETHANOL 2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL Ryanodine 1,4-Cyclohexanedimethanol trans-1,2-Cyclopentanediol CYCLODODECYLMETHYL ETHER CYCLOOCTANOL CIS-1,2-CYCLOOCTANEDIOL (1S)-TRANS-1,2-CYCLOPENTANEDIOL (1R)-TRANS-1,2-CYCLOPENTANEDIOL MONOACETATE (3S,5S)-2,6-Dimethyl-3,5-heptanediol (R,R)-(-)-1,2-CYCLODODECANEDIOL (-)-NEOMENTHOL CIS-P-MENTHANE-3,8-DIOL 3-Deoxyryanodol (S,S)-(+)-1,2-CYCLODODECANEDIOL

Ryanodine, High Purity - CAS 15662-33-6 - Calbiochem

Ryanex

Ryanexcel

Ryanodine,99%

6-(1α,5aβ,8aβ,9-pentahydroxy-7β-isopropyl-2β,5β,8β-trimethylperhydro-8bα,9-epoxy-5,8-ethanocyclopenta[1,2-b]indenyl) pyrrole-2-carboxylate ryania

Ryanodine from Ryania speciosa

Ryanodol 3-(1H-pyrrole-2-carboxylate) from Ryania speciosa

RYANODINE MIXTURE

RYANADOL

RYANADOL 3-(1H-PYRROLE-2-CARBOXYLATE)

Ryania(content>30%)

Ryanicide

RYANODINE

RYANODOL-3-(1H-PYRROLE-2-CARBOXYLATE)

1H-PYRROLE-2-CARBOXYLIC ACID, (3S,4R,4AR,6S,7S,8R,8AS,8BR,9S,9AS)-DODECAHYDRO-4,6,7,8A,8B,9A-HEXAHYDROXY-3,6A,9-TRIMETHYL-7-(1-METHYLETHYL)-6,9-METHANOBENZO[1,2]PENTALENO[1,6-BC]FURAN-8-YL ESTER

3-(1H-PYR-ROLE-2-CARBOXYLATE)

bonideryatox

groundryaniaspecisa(vahl)stemwood(alkoloidryanodine)

ryanexel

1H-Pyrrole-2-carboxylic acid, (3S,4R,4aR,6S,6aS,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl ester

ryania

ryaniapowder

ryaniaspeciosa

ryanodinealkaloid

6-(1alpha,5abeta,8abeta,9-pentahydroxy-7beta-isopropyl-2beta,5beta,8beta-trimethylperhydro-8balpha,9-epoxy-5,8-ethanocyclopenta[1,2-b]indenyl) pyrrole-2-carboxylate

RYANODINE >98% (RYANADOL, 3-(1H-PYRR

RYANODINE FROM RYANIA SPECIOSA MINIMUM &

RYANODINE FROM RYANIA SPECIOSA INHIBITS CALCIUM RELEASE FROM THE SARCOPLASMIC RETICULUM

RYANODINE FROM RYANIA SPECIOSA A MIXTURE OF RYANODINE AND 9,21-DEHYDRORYANODINE (1:1)

RYANODINE HIGH PURITY

1H-Pyrrole-2-carboxylicacid(3S,4R,4aR,6S,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethy]

9,21-DEHYDRO(RG)

Ryanodine, Ca2+ release modulator

15662-33-6

C25H35NO9

Signalling

Alkaloids

InsP3/Ryanodine receptor