4-METHOXY-2-NITRO-BENZALDEHYDE

Product Name: 4-METHOXY-2-NITRO-BENZALDEHYDE
CAS No.: 22996-21-0
Chemical Name: 4-METHOXY-2-NITRO-BENZALDEHYDE
Synonyms: 4-Mehtyl-2-Nitro-Benzaldehyde;4-Methoxy-2-nitrobenzaL;4-METHOXY-2-NITRO-BENZALDEHYDE;Benzaldehyde, 4-methoxy-2-nitro-;4-METHOXY-2-NITRO-BENZALDEHYDE ISO 9001：2015 REACH;4-Formyl-3-nitroanisole, 2-Formyl-5-methoxynitrobenzene
CBNumber: CB1485239
Molecular Formula: C8H7NO4
Formula Weight: 181.15
MOL File: 22996-21-0.mol

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4-METHOXY-2-NITRO-BENZALDEHYDE Property

Melting point:: 95.5-96 °C(Solv: chloroform (67-66-3); ligroine (8032-32-4))
Boiling point:: 354.7±27.0 °C(Predicted)
Density: 1.322±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: powder
color: Yellow
CAS DataBase Reference: 22996-21-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
HS Code: 2913000090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M219348
Product name: 4-Methoxy-2-nitrobenzaldehyde
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 072331
Product name: 4-Methoxy-2-nitrobenzaldehyde
Purity: 95+%
Packaging: 5g
Price: $74
Updated: 2021/12/16

Matrix Scientific

Product number: 072331
Product name: 4-Methoxy-2-nitrobenzaldehyde
Purity: 95+%
Packaging: 1g
Price: $21
Updated: 2021/12/16

AK Scientific

Product number: J55138
Product name: 4-Methoxy-2-nitrobenzaldehyde
Packaging: 1g
Price: $22
Updated: 2021/12/16

AK Scientific

Product number: W4676
Product name: 4-Methoxy-2-nitrobenzaldehyde
Packaging: 5g
Price: $101
Updated: 2021/12/16

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4-METHOXY-2-NITRO-BENZALDEHYDE Chemical Properties,Usage,Production

Uses

4-Methoxy-2-nitrobenzaldehyde is soluble in both water and ethanol. Its uses include the study of enzyme inhibition and regulation of gene expression. As an inhibitor of drug-metabolizing enzymes, it binds to the active site of the enzyme and impedes its catalytic function. In addition, it is an important tool for studying the regulation of gene expression.

Synthesis

17484-36-5

22996-21-0

Example 4 Preparation of 3-[7-(1-methylpiperidin-4-yloxy)quinazolin-2-yl]aminobenzenesulfonamide Step 1. Preparation of 4-methoxy-2-nitrobenzaldehyde 4-Methyl-3-nitroanisole (20.43 g, 0.122 mol, 1.0 eq.) was dissolved in 480 mL of CCl4 under the protection of Ar atmosphere. N-bromosuccinimide (NBS, 48.94 g, 0.275 mol, 2.2 eq.) was added to the solution as a one-time addition, followed by benzoyl peroxide (0.67 g, 2.76 mmol). The reaction mixture was stirred under reflux conditions for 4.5 hours. An aliquot was analyzed by 1H NMR showing that about 90% of the starting material was converted to the dibromo derivative. The reaction mixture was cooled to room temperature and concentrated. The residual CCl4 was removed by azeotropic distillation with acetone twice. The residue was dissolved in acetone (1 L) and silver carbonate (Ag2CO3, 37.1 g, 0.135 mol, 1.1 equiv) and water (100 mL) were added. The reaction mixture was stirred at room temperature overnight. The reaction progress was monitored by TLC (unfolding agent ratio: EtOAc:hexane = 3:7) and the formation of new spots was observed. The reaction mixture was filtered through a PP028218.0002 filter, the filter cake was washed with acetone and the filtrate was concentrated. To the crude product, 340 mL of water was added and the product was extracted with EtOAc (800 mL, 400 mL). The emulsion formed was filtered through diatomaceous earth to separate the organic and aqueous layers. The organic layer was washed with brine, dried over anhydrous Na2SO4 and concentrated to give 8.27 g of crude product. The crude product was purified by column chromatography (eluent: EtOAc/hexane) to give 14.7 g (67% yield) of the pure compound 4-methoxy-2-nitrobenzaldehyde.

References

[1] Patent: WO2007/117607, 2007, A2. Location in patent: Page/Page column 309-310
[2] Journal of the Chemical Society, 1949, p. Spl. 231
[3] Chemical and Pharmaceutical Bulletin, 1962, vol. 10, p. 856 - 865
[4] J. Gen. Chem. USSR (Engl. Transl.), 1960, vol. 30, p. 3091 - 3095
[5] Zhurnal Obshchei Khimii, 1960, vol. 30, # 9, p. 3118

4-METHOXY-2-NITRO-BENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-METHOXY-2-NITRO-BENZALDEHYDE Suppliers

China 150 India 6 Switzerland 1 United Kingdom 7 United States 16 Global 180

HBCChem, Inc.

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View Lastest Price from 4-METHOXY-2-NITRO-BENZALDEHYDE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-methoxy-2-nitrobenzaldehyde 22996-21-0
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-12-02

Henan Fengda Chemical Co., Ltd

Product: 4-METHOXY-2-NITRO-BENZALDEHYDE 22996-21-0
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-24

Shanghai Rlavie Technology Co ltd

Product: 4-Methoxy-2-nitrobenzaldehyde 22996-21-0
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: 100kgs/month
Release date: 2021-11-21

22996-21-0, 4-METHOXY-2-NITRO-BENZALDEHYDERelated Search:

Methyl 4,5-dimethoxy-2-nitrobenzoate 6-NITROPIPERONAL 3,4-DIMETHOXY-6-NITROBENZAMIDE 6-Nitroveratraldehyde ETHYL 4,5-DIMETHOXY-2-NITROBENZOATE 4-METHOXY-2-NITRO-BENZALDEHYDE D-ribo-Hexanoic acid, 3-deoxy-, γ-lactone 4,5-METHYLENEDIOXY-2-NITROACETOPHENONE Methyl 2-nitro-3,4,5-trimethoxybenzoate 3-METHOXY-5-NITROBENZALDEHYDE 2-METHOXY-4-NITROBENZALDEHYDE Propargyl p-toluenesulfonate 5-Methoxy-2-nitrobenzaldehyde 2-HYDROXY-3-METHOXY-5-NITROBENZALDEHYDE 4-METHOXY-3-NITROBENZALDEHYDE 3-Methoxy-2-nitrobenzaldehyde 2-HYDROXY-5-METHOXY-3-NITRO-BENZALDEHYDE O-NITROPIPERONAL

4-METHOXY-2-NITRO-BENZALDEHYDE

4-Mehtyl-2-Nitro-Benzaldehyde

4-Formyl-3-nitroanisole, 2-Formyl-5-methoxynitrobenzene

Benzaldehyde, 4-methoxy-2-nitro-

4-Methoxy-2-nitrobenzaL

4-METHOXY-2-NITRO-BENZALDEHYDE ISO 9001：2015 REACH

22996-21-0

Aldehydes

Phenyls & Phenyl-Het