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Sulfanilic acid

Synthesize
Product Name
Sulfanilic acid
CAS No.
121-57-3
Chemical Name
Sulfanilic acid
Synonyms
SULPHANILIC ACID;4-AMINOBENZENESULFONIC ACID;sulfanilic;P-AMINOBENZENESULFONIC ACID;4-aminobenzenesulfonate;SULFANILLIC ACID;Sulphanillic Acid;ANILINE-4-SULFONIC ACID;SULFANILIC ACID ANHYD PWD;4-AMINOBENZENESULPHONIC ACID
CBNumber
CB1489237
Molecular Formula
C6H7NO3S
Formula Weight
173.19
MOL File
121-57-3.mol
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Sulfanilic acid Property

Melting point:
>300 °C(lit.)
Boiling point:
288 ℃
Density 
1.485
vapor pressure 
0Pa at 25℃
refractive index 
1.5500 (estimate)
storage temp. 
Store below +30°C.
solubility 
10g/l
pka
3.24(at 25℃)
form 
solid
color 
White to Off-White
PH
2.5 (10g/l, H2O, 20℃)
Water Solubility 
0.1 g/100 mL (20 ºC)
Merck 
14,8926
BRN 
908765
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
HVBSAKJJOYLTQU-UHFFFAOYSA-N
LogP
-2.3 at 25℃
CAS DataBase Reference
121-57-3(CAS DataBase Reference)
NIST Chemistry Reference
Benzenesulfonic acid, 4-amino-(121-57-3)
EPA Substance Registry System
Sulfanilic acid (121-57-3)
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Safety

Hazard Codes 
C,Xi
Risk Statements 
36/38-43-34
Safety Statements 
26-36/37/39-45-37-24-36/37
RIDADR 
UN 2790 8/PG 3
WGK Germany 
1
RTECS 
WP3895500
Autoignition Temperature
>400 °C
TSCA 
Yes
HS Code 
29214210
Hazardous Substances Data
121-57-3(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 12300 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.22338
Product name
Sulfanilic acid
Purity
for synthesis
Packaging
100g
Price
$34
Updated
2024/03/01
Sigma-Aldrich
Product number
8.22338
Product name
Sulfanilic acid
Purity
for synthesis
Packaging
1kg
Price
$91.4
Updated
2024/03/01
Sigma-Aldrich
Product number
8.22338
Product name
Sulfanilic acid
Purity
for synthesis
Packaging
50kg
Price
$1040
Updated
2024/03/01
Sigma-Aldrich
Product number
251917
Product name
Sulfanilic acid
Purity
ACS reagent, 99%
Packaging
25g
Price
$33.5
Updated
2024/03/01
Sigma-Aldrich
Product number
39441
Product name
Nitrate Reagent B
Purity
suitable for microbiology
Packaging
100mL
Price
$45.7
Updated
2024/03/01
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Sulfanilic acid Chemical Properties,Usage,Production

Synthesize

Sulfanilic acid can be used for the determination of nitrite. Biochemical Research. Organic Synthesis. Sulfanilic acid is an important intermediate of sulfonamide drugs. This product has strong antibacterial effect on hemolytic streptococcus, meningitis and coccus, but due to poor efficacy and high toxicity, it is rarely used for oral administration. It is also rarely used. It is used as an intermediate for the synthesis of other sulfonamides, and is also used as a raw material for the synthesis of agricultural "Huangcaoling" abroad. Sulfanilic acid can also be used as an analytical reagent, such as a reagent for the photometric determination of nitrite and sodium nitroferricyanide. For biochemical research, organic synthesis and pharmaceutical industry. Sulfanilic acid is the main raw material for synthesizing sulfonamides. In addition to preparing crystalline sulfonamides for external anti-inflammatory, it can also synthesize other sulfonamides such as sulfamidine, sulfamethoxazine, and sulfamethazine.

Description

Sulfanilic acid (4-amino benzene sulfonic acid ) is an off-white crystalline solid which finds application in quantitative analysis of nitrate and nitrite ions. The solid acid exists as a zwitterion, and has an unusually high melting point.

Chemical Properties

greyish-white crystals or powder

Uses

Sulfanilic Acid (Sulfadimethoxine EP Impurity D) is a toxic metabolite of Tartrazine (T007700). Used as Ehrlich’s reagent, for detecting of nitrites. Antibacterial.

Uses

Sulfanilic acid may be used for the functionalization of single-walled carbon nanotubes (SWNTs) with aryl sulfonate groups.

Uses

A toxic metabolite of Tartrazine (T007700). Used as Ehrlich’s reagent, for detecting of nitrites. Antibacterial.

Application

As the compound readily form diazo compounds, it is used to make dyes and sulpha drugs . This property is also used for the quantitative analysis of nitrate and nitrite ions by diazonium coupling reaction with N-(1-Naphthyl) ethylene diamine , resulting in an azo dye, and the concentration of nitrate or nitrite ions were deduced from the color intensity of the resulting red solution by colorimetry.
It is also used as a standard in combustion analysis.

Definition

ChEBI: An aminobenzenesulfonic acid that is aniline sulfonated at the para-position.

General Description

White powder with faint purple tinge. Grayish-white flat crystals. Becomes anhydrous at around 212°F. Low toxicity (used medicinally).

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Sulfanilic acid is an amino acid. Reacts weakly with both acids and bases.

Fire Hazard

Flash point data for Sulfanilic acid are not available, however Sulfanilic acid is probably combustible.

Synthesis

Sulfanilic acid can be produced by sulfonation of aniline.

Purification Methods

Crystallise the acid (as dihydrate) from boiling water. Dry it at 105o for 2-3hours, then over 90% H2SO4 in a vacuum desiccator. The S-benzylisothiuronium salt has m 187o (from aqueous EtOH). [Beilstein 14 IV 2655.]

Sulfanilic acid Preparation Products And Raw materials

Raw materials

Aniline Sulfuric acid

Preparation Products

Acid Orange 7 ACID YELLOW 17 Acid Orange 156 Direct Red Brown RN AURAMINE O Direct Blending Brilliant Red D-10BL REACTIVE GREEN 19 4-amino-1-naphthol Reactive Dark Blue M-2ge Sumilight Supra Orangl 2GL Tartrazine Methyl Orange CIBACRON BRILLIANT YELLOW 3G-P 4-Chlorobenzenesulfonic acid Fluorescent Brightener VBU DIRECT RED 80 8,8-Dimethoxy-2,6-dimethyloctan-2-ol Direct Blending Brilliant Red D-5BL Piperonyl aldehyde Reactive Red 15 4-Amino-benzenesulfonic acid monosodium salt N-Phenyl-1-naphthylamine 4-Amino-1,3-benzenedisulfonic acid sodium N-benzylsulphanilate C. I. Pigment Red 56 Sunset Yellow FCF Acid Yellow 199 Direct Blend Rubine D-BLL new red REACTIVE RED 4 p-Anisaldehyde Direct Blending Yellow D-3RNL 4-Chlorobenzenesulfonyl chloride Direct Violet 9 Reactive Violet 2 Direct Blending Scarlet D-GLN
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View Lastest Price from Sulfanilic acid manufacturers

Hebei Duling International Trade Co. LTD
Product
Sulfanilic acid 121-57-3
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000tons
Release date
2023-04-24
Hebei Yanxi Chemical Co., Ltd.
Product
Sulfanilic acid 121-57-3
Price
US $1.00/kg
Min. Order
1kg
Purity
99.00%
Supply Ability
20tons
Release date
2023-09-08
Hebei Mojin Biotechnology Co., Ltd
Product
Sulfanilic acid 121-57-3
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-06-20

121-57-3, Sulfanilic acidRelated Search:

Ethyl 2-(Chlorosulfonyl)acetate Hyaluronic acid Sulfanilamide 4-Aminobenzoic acid Stearic acid Citric acid 4-Aminobenzaldehyde p-Anisidine Folic acid Ascoric Acid p-[[(4-chlorobutyl)sulphonyl]amino]benzenesulphonamide N-acetylsulphanilic acid 4-(Acetylamino)-N-(2,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide Sulfadimethoxine-d6 Sulfadimethoxine 4-Amino-2,6-dimethoxypyrimidine 1,3-di(4-sulfamoylphenyl)triazene SULFADIMETHOXINE-D4

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