ChemicalBook > CAS DataBase List > Robenidine hydrochloride

Robenidine hydrochloride

Product Name
Robenidine hydrochloride
CAS No.
25875-50-7
Chemical Name
Robenidine hydrochloride
Synonyms
ROBENIDINE HCL;Robenz;Nugatex;cycostat;Toraxine;khimroside;khimcoccid;Rasexinium;CYCOSTAT66G;chimcoccide
CBNumber
CB1491966
Molecular Formula
C15H14Cl3N5
Formula Weight
370.66
MOL File
25875-50-7.mol
More
Less

Robenidine hydrochloride Property

Melting point:
252-254°C
storage temp. 
0-6°C
solubility 
Robenidine hydrochloride possesses a weak solubility in water (<1 mg/L), but is soluble in organic solvents: 94 mg/L in dimethylsulfoxide, 46 mg/L in dimethylformamide, 20 mg/L in pyridine and 6.3 mg/L in ethanol (95%). The Log Kow is 3.3 (EFSA, 2004a).
CAS DataBase Reference
25875-50-7(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
2
RTECS 
ME8651000
Toxicity
mouse,LD50,oral,390mg/kg (390mg/kg),Journal of Agricultural and Food Chemistry. Vol. 23, Pg. 724, 1975.
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
33979
Product name
Robenidine hydrochloride
Purity
VETRANAL?,analyticalstandard
Packaging
100mg
Price
$119
Updated
2024/03/01
TRC
Product number
R639000
Product name
Robenidine hydrochloride
Packaging
100mg
Price
$80
Updated
2021/12/16
ApexBio Technology
Product number
C6934
Product name
Robenidine hydrochloride
Packaging
200mg
Price
$85
Updated
2021/12/16
AK Scientific
Product number
I008
Product name
RobenidineHCl
Packaging
1g
Price
$90
Updated
2021/12/16
Biosynth Carbosynth
Product number
IB57827
Product name
1,3-Bis[(p-chlorobenzylidene)amino]guanidine hydrochloride
Packaging
25g
Price
$100
Updated
2021/12/16
More
Less

Robenidine hydrochloride Chemical Properties,Usage,Production

Description

Robenidine hydrochloride (Dexium, Nugatex, Rasexinium, Toraxine) is an antibiotic used as an effective anticoccidial. It does not affect the earliest stages in the coccidial life-cycle and its main activity is against the almost mature first generation schizont. It is used as an aid in the prevention of coccidiosis caused by Eimeria mivati, E. brunetti, E. tenella, E. acervulina, E. maxima and E. necatrix in broiler chickens.

Chemical Properties

white or slightly yellow crystalline powder, odorless, slightly bitter taste. Very slightly soluble in ether and water, easily soluble in dilute acid or dilute alkali solution, the color gradually darkens when exposed to light.

Uses

Robenidine hydrochloride is used as a coccidiostat for use in chickens for fattening and turkeys at a minimum-maximum concentration of 30-36 mg/kg complete feed, and in rabbits for fattening at a minimummaximum concentration of 50-66 mg/kg complete feed withdrawal period of 5 days for all target animals.

Preparation

thiosemicarbazide was formed by addition and rearrangement of sodium thiocyanate with water and hydrazine. Then methylation with dimethyl sulfate and hydrazinolysis to give N.N'-diaminoguanidine sulfate. Then replaced with calcium chloride to N.N'-diaminoguanidine hydrochloride. Finally, it was condensed with p-chlorobenzaldehyde in ethanol again to produce Robenidine hydrochloride with 94% yield.

Antimicrobial activity

Robenidine hydrochloride activity against Eimeria species results from a dual action exerted upon different stages of the parasite as it develops in the intestinal mucosa (Ryley and Wilson, 1971). Initially it acts as a coccidiostat and arrests the development of the first schizont generation. Secondly, robenidine hydrochloride is coccidiocidal, killing the second generation of schizonts and possibly the merozoites. An additional effect against the sexual stage of coccidia development has been observed as well. Robenidine hydrochloride has been shown to be an inhibitor of oxidative phosphorylation (Wong et al., 1972) and is reported to affect the protein metabolism and some other metabolic process of coccidia (Lee and Millard, 1972).

Biological Activity

Robenidine Hydrochloride is an anticoccidial agent mainly for poultry which is also active against MRSA and VRE with MIC50s of 8.1 and 4.7 μM, respectively. IC50 & Target: MIC50: 8.1 μM (MRSA), 4.7 μM (VRE).
In Vitro: Robenidine (compound 1) inhibits the growth of MRSA and VRE with MIC values of 8.1 and 4.7 μM, respectively. Robenidine is bactericidal against all of the S. aureus strains tested with MBC/MIC90 ratios ≤2. A profound and negative impact on the MIC values with a 4-fold decrease with Robenidine at 2% serum and no activity at 50% serum is observed.
In Vivo: The time that the mean plasma concentration exceeds the concentration of 1 μg/mL is approximately 6 h in the Florfenicol (FFC) alone group; however, it is lowered to 4 h by Robenidine (ROB) pretreatment. The terminal elimination half-life (t1/2z), area under the concentration-time curve (AUC), area under the first moment curve (AUMC), and mean residence time (MRT) significantly decreased, whereas the elimination rate constant (λz) and total body clearance (CLz) obviously increased in rabbits pretreated with Robenidine.

Robenidine hydrochloride Preparation Products And Raw materials

Raw materials

thiosemicarbazide Acetylacetone 4-Chlorobenzaldehyde Sodium thiocyanate Bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide hydrochloride Benzaldehyde Metaclazepam Sulfaguanidine Diaminoguanidine sulfate

Preparation Products

More
Less

Robenidine hydrochloride Suppliers

Belgium 1 Canada 2 China 201 Czech Republic 1 Europe 3 Germany 4 India 8 Japan 2 South Korea 1 Spain 2 Switzerland 1 The Netherlands 1 United Kingdom 8 United States 22 Uruguay 1 Global 258
Jinan Wald Chemical Co., Ltd.
Tel
0531-88773586 13210588999
Fax
053188773586
Email
304264064@qq.com
Country
China
ProdList
193
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9984
Advantage
60
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9816
Advantage
59
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-0712-2580635 15527768850
Email
1791901229@qq.com
Country
China
ProdList
8849
Advantage
52
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7815
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14443
Advantage
57
Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
4388
Advantage
65
Wuhan Fortuna Chemical Co., Ltd
Tel
027-027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2893
Advantage
58
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4941
Advantage
60
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9552
Advantage
55
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3750
Advantage
55
Zouping Mingxing Chemical Co.,Ltd.
Tel
86-13605431940 13605431940
Fax
0086-0543-2240079
Email
zpmxchemical@126.com
Country
China
ProdList
2002
Advantage
62
Quzhou Juhua Friendship Co., Ltd
Tel
0570-3066667
Fax
0570-3063388
Country
China
ProdList
3933
Advantage
58
Wuhan DKY Technology Co.,Ltd.
Tel
27-81302488 18007166089
Fax
027-81302088
Email
info@dkybpc.com
Country
China
ProdList
2024
Advantage
58
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4951
Advantage
58
Wuhan Dahua Weiye Pharmaceutical Chemical Co., Ltd.
Tel
027-59420981,18702770802
Fax
027-83322098
Country
China
ProdList
1975
Advantage
50
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9972
Advantage
58
Alta Scientific Co., Ltd.
Tel
022-6537-8550 15522853686
Fax
022-2532-9655
Email
sales@altasci.com.cn
Country
China
ProdList
4515
Advantage
55
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
551-65418679 15837135945
Fax
0551-65418697
Email
info@tnjchem.com
Country
China
ProdList
1889
Advantage
62
Nanjing Vital Chemical Co., Ltd.
Tel
025-87193546 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
9030
Advantage
60
Nanjing XiLang Chemical Products Co., Ltd.
Tel
025-5276156 18936048580
Email
chemxilang@163.com
Country
China
ProdList
4009
Advantage
58
Shanghai QianYan Bio-technology Co., Ltd
Tel
02781293128
Email
orders@biochemsafebuy.com
Country
China
ProdList
9934
Advantage
55
Raw material medicin reagent co.,Ltd
Tel
025-57798860
Email
sales@njromanme.com
Country
China
ProdList
4534
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-0371-55629727 13323845623
Fax
037155629727
Email
2885676761@qq.com
Country
China
ProdList
9859
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29797
Advantage
68
Hubei widely chemical technology Co., Ltd.
Tel
027-83991130 18627774460
Fax
027-83991130
Email
1718093273@QQ.COM
Country
China
ProdList
1891
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131981
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12308
Advantage
58
Wuhan Wsem Biological Co., Ltd.
Tel
027-83778876 13667159345
Fax
027-83778876
Email
13667159345@163.com
Country
China
ProdList
1941
Advantage
55
Wuhan Magic Biological Technology Co., Ltd.
Tel
18872289958、027-52304252、3400508168
Fax
027-52304252
Email
3400508168@qq.com
Country
China
ProdList
1910
Advantage
55
Guangzhou Jhd Chemical Reagent Co., Ltd.
Tel
020-84383047
Fax
020-84380294
Email
sales@jhd.com.cn
Country
China
ProdList
9190
Advantage
65
Shanghai Orgchem Co.,Ltd.
Tel
+86-21-5877 1921
Fax
+86-21-5877 1925
Email
info@chemofchina.com
Country
China
ProdList
9661
Advantage
55
Jinan Londi Medical Technology Co., LTD
Tel
0531-88996911 15628983711
Fax
0531-88996911
Email
3305202763@qq.com
Country
China
ProdList
125
Advantage
58
Aikon International Limited
Tel
025-66113011 13155353615
Fax
(7)02557626880
Email
qzhang@aikonchem.com
Country
China
ProdList
15396
Advantage
58
Rhawn Reagent
Tel
400-400-1332688 18019345275
Fax
400-133-2688
Email
amy@rhawn.cn
Country
China
ProdList
15503
Advantage
58
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400-6387771-6038 18902104717
Email
sales@heowns.com
Country
China
ProdList
20512
Advantage
60
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-51831887 15337167856
Fax
027-51837635 QQ1165326703
Email
hubeixinyuanshun@163.com
Country
China
ProdList
10305
Advantage
58
Chengdu Saint - Kay Biotechnology Co., Ltd.
Tel
028-85157043 15882256948
Email
676046971@qq.com
Country
China
ProdList
4392
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
400-400-400-9004166 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52712
Advantage
58
PeiShen biological engineering (Shanghai) co., LTD
Tel
021-33040955-0 13651980230
Fax
021-61330236
Email
pszsy@pssh.com.cn
Country
China
ProdList
151
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 13028896684
Email
sales@rrkchem.com
Country
China
ProdList
55827
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9730
Advantage
58
Wuhan Mengqi Technology Co., Ltd.
Tel
027-83232706 15871702139
Email
3454407469@qq.com
Country
China
ProdList
662
Advantage
58
Hubei Hongjing Chemical Co., Ltd.
Tel
13669024603
Fax
027-82333386
Email
hb_hjhg@163.com
Country
China
ProdList
131
Advantage
58
Guangzhou Tomums Life Science Co., Ltd.
Tel
020-31155029 18902330969
Fax
020-31155029
Email
sales@tomums.cn
Country
China
ProdList
4698
Advantage
58
Wuhan yuqing jiaheng pharmaceutical co. LTD
Tel
027-83855389 13545340383
Fax
027-83855389
Email
2586905842@qq.com
Country
China
ProdList
1246
Advantage
58
Hebei Yanxi Chemical Co., Ltd.
Tel
+8617531190177
Email
peter@yan-xi.com
Country
China
ProdList
5993
Advantage
58
Hebei Mojin Biotechnology Co., Ltd
Tel
+8613288715578
Email
sales@hbmojin.com
Country
China
ProdList
12456
Advantage
58
More
Less

View Lastest Price from Robenidine hydrochloride manufacturers

Ouhuang Engineering Materials (Hubei) Co., Ltd
Product
Robenidine hydrochloride 25875-50-7
Price
US $10.00/kg
Min. Order
1kg
Purity
99.8%
Supply Ability
10000ton
Release date
2024-04-25
Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
Robenidine HCl 25875-50-7
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2024-04-10
Hebei Duling International Trade Co. LTD
Product
Robenidine hydrochloride 25875-50-7
Price
US $34.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2023-01-07

25875-50-7, Robenidine hydrochlorideRelated Search:

2-Aminothiazol hydrochloride,solution Iminodibenzyl Guanidine hydrochloride Meclizine dihydrochloride Betaine Semicarbazide hydrochloride AMINOGUANIDINE HYDROCHLORIDE ALTRENOGEST Glycine Amino tris(methylene phosphonic acid) (S)-2-Aminobutyramide hydrochloride Topotecan hydrochloride DODECYLGUANIDINE HYDROCHLORIDE trans-4-Phenyl-3-buten-2-one Moroxydine hydrochloride Metformin hydrochloride Phenformin hydrochloride D-Glucosamine hydrochloride

  • Robenidine hydrochloride
  • Robenidine HCL Pure
  • 1,3-Bis(4-chlorobenzylideneaMino)guanidine Hydrochloride
  • 2,2'-Bis[(4-chlorophenyl)Methylene]carboniMidic Dihydrazide Hydrochloride
  • ChiMcoccid Hydrochloride
  • KhiMcoccid Hydrochloride
  • Robenidine hyd
  • Robenidine Hydrochoride
  • cycostat
  • 1,3-BIS[(4-CHLOROBENZYLIDENE)AMINO]GUANIDINE MONOHYDROCHLORIDE
  • Robenzidene, Cycostat, Robenz
  • ROBENDINE HCL
  • Carbonimidic dihydrazide, bis(4-chlorophenyl)methylene-, monohydrochloride
  • khimroside
  • CYCOSTAT66G
  • Robenidinhydrochlorid
  • 1,3-bis((p-chlorobenzylidene)amino)-guanidin
  • 1,3-bis((p-chlorobenzylidene)amino)guanidine
  • bis((4-chlorophenyl)methylene)-carbonimidic dihydrazid
  • chimcoccide
  • khimcoccid
  • khimkoktsid
  • khimkoktside
  • 1,3-Bis-(P-cheobenzy-tidene-amino)guanidine
  • robenzidene
  • Robenidine (base and/or unspecified salts)
  • CARBONIMIDICDIHYDRAZIDE,BIS[(4-CHLOROPHENYL)METHYLENE]
  • Robenz
  • 1,3 bis(4-(p-chloro. benzylidene)amino]guanidine
  • ROBENIDINE 98%
  • Suifadimidine(SDM)
  • ROBENIDINE HCL
  • 1,3-bis((p-chlorobenzylidene)amino)guanidinehydrochloride
  • 1,3-bis((p-chlorobenzylidene)amino)-guanidinmonohydrochloride
  • bis((4-chlorophenyl)methylene)-carbonimidicdihydrazidmonohydrochloride
  • Robenidine Solution, 1000ppm
  • Robenidine Hydrochloride Standard
  • Nugatex
  • Rasexinium
  • Toraxine
  • Robenidine hydrochloride USP/EP/BP
  • Robenidin hydrochloride
  • Robenidine hydrochloride (API)
  • Bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide hydrochlorid
  • Robenidine hydrochloride,inhibit,Robenidine,Parasite,Bacterial,Inhibitor
  • 25875-50-7
  • C27H14N5CL
  • C15H13CI2N5HCI
  • C15H13Cl2N5HCl
  • C15H14Cl3N5
  • Pharmaceutical intermediate
  • API
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Inhibitors