Robenidine hydrochloride

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Robenidine hydrochloride

Product Name: Robenidine hydrochloride
CAS No.: 25875-50-7
Chemical Name: Robenidine hydrochloride
Synonyms: ROBENIDINE HCL;Robenz;Nugatex;cycostat;Toraxine;khimroside;khimcoccid;Rasexinium;CYCOSTAT66G;chimcoccide
CBNumber: CB1491966
Molecular Formula: C15H14Cl3N5
Formula Weight: 370.66
MOL File: 25875-50-7.mol

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Robenidine hydrochloride Property

Melting point:: 252-254°C
storage temp.: 0-6°C
solubility: Robenidine hydrochloride possesses a weak solubility in water (<1 mg/L), but is soluble in organic solvents: 94 mg/L in dimethylsulfoxide, 46 mg/L in dimethylformamide, 20 mg/L in pyridine and 6.3 mg/L in ethanol (95%). The Log Kow is 3.3 (EFSA, 2004a).
form: Solid
color: White to off-white
CAS DataBase Reference: 25875-50-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 2
RTECS: ME8651000
Toxicity: mouse,LD50,oral,390mg/kg (390mg/kg),Journal of Agricultural and Food Chemistry. Vol. 23, Pg. 724, 1975.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 33979
Product name: Robenidine hydrochloride
Purity: VETRANAL?,analyticalstandard
Packaging: 100mg
Price: $119
Updated: 2024/03/01

TRC

Product number: R639000
Product name: Robenidine hydrochloride
Packaging: 100mg
Price: $80
Updated: 2021/12/16

ApexBio Technology

Product number: C6934
Product name: Robenidine hydrochloride
Packaging: 200mg
Price: $85
Updated: 2021/12/16

AK Scientific

Product number: I008
Product name: RobenidineHCl
Packaging: 1g
Price: $90
Updated: 2021/12/16

Biosynth Carbosynth

Product number: IB57827
Product name: 1,3-Bis[(p-chlorobenzylidene)amino]guanidine hydrochloride
Packaging: 25g
Price: $100
Updated: 2021/12/16

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Robenidine hydrochloride Chemical Properties,Usage,Production

Description

Robenidine hydrochloride (Dexium, Nugatex, Rasexinium, Toraxine) is an antibiotic used as an effective anticoccidial. It does not affect the earliest stages in the coccidial life-cycle and its main activity is against the almost mature first generation schizont. It is used as an aid in the prevention of coccidiosis caused by Eimeria mivati, E. brunetti, E. tenella, E. acervulina, E. maxima and E. necatrix in broiler chickens.

Chemical Properties

white or slightly yellow crystalline powder, odorless, slightly bitter taste. Very slightly soluble in ether and water, easily soluble in dilute acid or dilute alkali solution, the color gradually darkens when exposed to light.

Uses

Robenidine hydrochloride is used as a coccidiostat for use in chickens for fattening and turkeys at a minimum-maximum concentration of 30-36 mg/kg complete feed, and in rabbits for fattening at a minimummaximum concentration of 50-66 mg/kg complete feed withdrawal period of 5 days for all target animals.

Preparation

thiosemicarbazide was formed by addition and rearrangement of sodium thiocyanate with water and hydrazine. Then methylation with dimethyl sulfate and hydrazinolysis to give N.N'-diaminoguanidine sulfate. Then replaced with calcium chloride to N.N'-diaminoguanidine hydrochloride. Finally, it was condensed with p-chlorobenzaldehyde in ethanol again to produce Robenidine hydrochloride with 94% yield.

Antimicrobial activity

Robenidine hydrochloride activity against Eimeria species results from a dual action exerted upon different stages of the parasite as it develops in the intestinal mucosa (Ryley and Wilson, 1971). Initially it acts as a coccidiostat and arrests the development of the first schizont generation. Secondly, robenidine hydrochloride is coccidiocidal, killing the second generation of schizonts and possibly the merozoites. An additional effect against the sexual stage of coccidia development has been observed as well. Robenidine hydrochloride has been shown to be an inhibitor of oxidative phosphorylation (Wong et al., 1972) and is reported to affect the protein metabolism and some other metabolic process of coccidia (Lee and Millard, 1972).

Biological Activity

Robenidine Hydrochloride is an anticoccidial agent mainly for poultry which is also active against MRSA and VRE with MIC50s of 8.1 and 4.7 μM, respectively. IC50 & Target: MIC50: 8.1 μM (MRSA), 4.7 μM (VRE).
In Vitro: Robenidine (compound 1) inhibits the growth of MRSA and VRE with MIC values of 8.1 and 4.7 μM, respectively. Robenidine is bactericidal against all of the S. aureus strains tested with MBC/MIC90 ratios ≤2. A profound and negative impact on the MIC values with a 4-fold decrease with Robenidine at 2% serum and no activity at 50% serum is observed.
In Vivo: The time that the mean plasma concentration exceeds the concentration of 1 μg/mL is approximately 6 h in the Florfenicol (FFC) alone group; however, it is lowered to 4 h by Robenidine (ROB) pretreatment. The terminal elimination half-life (t1/2z), area under the concentration-time curve (AUC), area under the first moment curve (AUMC), and mean residence time (MRT) significantly decreased, whereas the elimination rate constant (λz) and total body clearance (CLz) obviously increased in rabbits pretreated with Robenidine.

Robenidine hydrochloride Preparation Products And Raw materials

Raw materials

thiosemicarbazide Acetylacetone 4-Chlorobenzaldehyde Sodium thiocyanate Bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide hydrochloride Benzaldehyde Metaclazepam Sulfaguanidine Diaminoguanidine sulfate

Preparation Products

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View Lastest Price from Robenidine hydrochloride manufacturers

Hebei Mujin Biotechnology Co.,Ltd

Product: Robenidine hydrochloride 25875-50-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-07-04

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Robenidine hydrochloride 25875-50-7
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-11-19

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Robenidine hydrochloride 25875-50-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%,USP
Supply Ability: 500kg/month
Release date: 2021-07-23

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Robenz

1,3 bis(4-(p-chloro. benzylidene)amino]guanidine

ROBENIDINE 98%

Suifadimidine(SDM)

ROBENIDINE HCL

1,3-bis((p-chlorobenzylidene)amino)guanidinehydrochloride

1,3-bis((p-chlorobenzylidene)amino)-guanidinmonohydrochloride

bis((4-chlorophenyl)methylene)-carbonimidicdihydrazidmonohydrochloride

Robenidine Solution, 1000ppm

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Toraxine

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Robenidine hydrochloride (API)

Bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide hydrochlorid

Robenidine hydrochloride,inhibit,Robenidine,Parasite,Bacterial,Inhibitor

Robenidine hydrochloride in methanol

(E)-N',2-bis((E)-4-chlorobenzylidene)hydrazine-1-carbohydrazonamide hydrochloride

Robenidine hydrochloride, 10 mM in DMSO

25875-50-7

C27H14N5CL

C15H13CI2N5HCI

C15H13Cl2N5HCl

C15H14Cl3N5

Pharmaceutical intermediate

API

Intermediates & Fine Chemicals

Pharmaceuticals

Inhibitors