HELENALIN

Product Name: HELENALIN
CAS No.: 6754-13-8
Chemical Name: HELENALIN
Synonyms: Helelin;NSC 85236;HELENALIN;CB1492352;HELENALIN(SH);HELENALIN USP/EP/BP;Helenalin (NSC 85236);a-dimethyl-3-methyleneazuleno[6,5-b]-furan-2,5-dione;(3as-(3aalpha,4alpha,4abeta,7aalpha,8alpha,9aalpha))-ethyl-3-methylene;6alpha,8beta-dihydroxy-4-oxoambrosa-2,11(13)-dien-12-oicacid12,8-lactone
CBNumber: CB1492352
Molecular Formula: C15H18O4
Formula Weight: 262.3
MOL File: 6754-13-8.mol

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HELENALIN Property

Melting point:: 167-168°
alpha: D25 -102.8° (c = 3.64 in 95% ethanol)
Boiling point:: 325.55°C (rough estimate)
Density: 1.0772 (rough estimate)
refractive index: 1.4300 (estimate)
storage temp.: -20°
solubility: Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 10 mg/ml).
form: White to off-white solid.
pka: 13.29±0.60(Predicted)
color: White
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
LogP: 0.870

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Safety

RIDADR: 2811
HazardClass: 6.1(b)
PackingGroup: III
Hazardous Substances Data: 6754-13-8(Hazardous Substances Data)
Toxicity: LD50 in mice, rats (mg/kg): 150, 125 orally (Witzel)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 374000
Product name: Helenalin, A. chamissonis ssp. foliosa
Packaging: 500μG
Price: $617
Updated: 2024/03/01

Cayman Chemical

Product number: 17050
Product name: Helenalin
Purity: ≥98%
Packaging: 1mg
Price: $504
Updated: 2024/03/01

TRC

Product number: H230000
Product name: Helenalin
Packaging: 0.25mg
Price: $160
Updated: 2021/12/16

ChemScene

Product number: CS-0078850
Product name: Helenalin
Purity: 98.29%
Packaging: 500ug
Price: $270
Updated: 2021/12/16

Adipogen Life Sciences

Product number: AG-CN2-0435-M001
Product name: Helenalin
Purity: ≥96%(HPLC)
Packaging: 1mg
Price: $390
Updated: 2021/12/16

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HELENALIN Chemical Properties,Usage,Production

Description

Helenalin (6754-13-8) is a novel sesquiterpene lactone which inhibits NFκB1?and displays potent anti-inflammatory activity2. It suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms.3 Helenalin also inhibits telomerase and this activity may be partially responsible for its anti-tumor effects.4

Uses

Helenalin is a highly toxic compound, with hepatic and lymphatic tissues particularly vulnerable to its effects. It is believed to be responsible for the toxicity and skin irritation associated with Arnica. If enough of the plant is ingested, the helenalin produces severe gastroenteritis and internal bleeding of the digestive tract.

Definition

ChEBI: Helenalin is a sesquiterpene lactone that is 3,3a,4,4a,7a,8,9,9a-octahydroazuleno[6,5-b]furan-2,5-dione substituted by a hydroxy group at position 4, methyl groups at positions 4a and 8 and a methylidene group at position 3 (the 3aS,4S,4aR,7aR,8R,9aR stereoisomer). It has a role as an anti-inflammatory agent, an antineoplastic agent, a plant metabolite and a metabolite. It is a gamma-lactone, a cyclic ketone, an organic heterotricyclic compound, a sesquiterpene lactone and a secondary alcohol.

storage

+4°C

References

1) Lyss?et al. (1998),?The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65; J. Biol. Chem.,?273?33508 2) Lyss?et al. (1997),?Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-κB; Biol. Chem.,?278?951 3) Berges?et al. (2009),?Helenalin suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms; Mol. Immunol.,?46?2892 4) Huang?et al. (2005),?Potent inhibition of human telomerase by helenalin; Cancer Lett.,?227?169

HELENALIN Preparation Products And Raw materials

Raw materials

Preparation Products

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HELENALIN Suppliers

China 52 Germany 1 India 3 Switzerland 1 United Kingdom 2 United States 9 USA 1 Global 69

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

Focus Biomolecules

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Cayman Chemical Company

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Country: United States
ProdList: 6213
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United States Biological

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Country: United States
ProdList: 6214
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Glentham Life Sciences Ltd

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ProdList: 2026
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MedChemExpress

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Country: United States
ProdList: 6398
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ChromaDex

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Country: United States
ProdList: 2501
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BIOMOL INTERNATIONAL, LP

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Country: United States
ProdList: 1499
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EMD Biosciences, Inc.

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Email: technical@calbiochem.com
Country: United States
ProdList: 6529
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View Lastest Price from HELENALIN manufacturers

Henan Fengda Chemical Co., Ltd

Product: CB1492352 6754-13-8
Price: US $32.00-1.30/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-28

6754-13-8, HELENALINRelated Search:

5-Aminosalicylic acid BAY 11-7085 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE 3'-Hydroxyrocaglamide panepoxydone Rocaglamide I Florilenalin HELENALIN N-NONYL ACRYLATE 1-HYDROXYMETHYL-3-CYCLOPENTENE ETHYL 6-KETO-7-OCTENOATE HELENALIN(RG) Autumnolide HELENALIN(REAGENT / STANDARD GRADE) 5-ETHYL-3-METHYLENE-DIHYDRO-FURAN-2-ONE bis(helenalinyl)malonate Helenalin, A. chamissonis ssp. foliosa helenalin methacrylate

(3as-(3aalpha,4alpha,4abeta,7aalpha,8alpha,9aalpha))-ethyl-3-methylene

HELENALIN(SH)

HELENALIN

6alpha,8beta-dihydroxy-4-oxoambrosa-2,11(13)-dien-12-oicacid12,8-lactone

a-dimethyl-3-methyleneazuleno[6,5-b]-furan-2,5-dione

ambrosa-2,11(13)-dien-12-oicacid,6-alpha,8-beta-dihydroxy-4-oxo-,12,8-lacton

ambrosa-2,11(13)-dien-12-oicacid,6alpha,8beta-dihydroxy-4-oxo-,12,8-lactone

azuleno(6,5-b)furan-2,5-dione,3,3a,4,4a,7a,8,9,9a-octahydro-4-hydroxy-4a,8-dim

Helenalin (NSC 85236)

[3as]-3,3aalpha,4alpha,4a,7aalpha,8,9,9aalpha-octahydro-4-hydroxy-4abeta,8alph

NSC 85236

Helelin

Azuleno[6,5-b]furan-2,5-dione, 3,3a,4,4a,7a,8,9,9a-octahydro-4-hydroxy-4a,8-dimethyl-3-methylene-, (3aS,4S,4aR,7aR,8R,9aR)-

(3aS,4S,4aR,7aR,8R,9aR)-4-hydroxy-4a,8-dimethyl-3-methylene-3,3a,4,4a,7a,8,9,9a-octahydroazuleno[6,5-b]furan-2,5-dione

HELENALIN USP/EP/BP

CB1492352

6754-13-8

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