ChemicalBook > CAS DataBase List > Glycyrrhizic acid ammonium salt

Glycyrrhizic acid ammonium salt

Product Name
Glycyrrhizic acid ammonium salt
CAS No.
53956-04-0
Chemical Name
Glycyrrhizic acid ammonium salt
Synonyms
MONOAMMONIUM GLYCYRRHIZINATE;Magnasweet;monoammoniumglycyrrhizate;glycyrrhizin monoammonium salt;Monoammonium Glycyrrhizinate S;GLYCYRRHIZINATE MONOAMMONIUM SALT;GLYCYRRHIZIC ACID MONOAMMONIUM SALT;GLYCAMIL;icorice);t from g
CBNumber
CB1492372
Molecular Formula
C42H65NO16
Formula Weight
839.97
MOL File
53956-04-0.mol
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Glycyrrhizic acid ammonium salt Property

Melting point:
>200°C (dec.)
Boiling point:
768.56°C (rough estimate)
Density 
1.1846 (rough estimate)
FEMA 
2528 | GLYCYRRHIZIN, AMMONIATED (GLYCYRRHIZA SPP.)
refractive index 
49 ° (C=1.5, EtOH)
storage temp. 
2-8°C
solubility 
Slightly soluble in water, very slightly soluble in anhydrous ethanol, practically insoluble in acetone. It dissolves in dilute solutions of acids and of alkali hydroxides.
form 
Powder or Crystals
color 
Yellow to yellow-green
Odor
bland
optical activity
[α]20/D +48±4°, c = 1% in ethanol: water (1:1)
BRN 
3897076
Stability:
Hygroscopic
InChIKey
ILRKKHJEINIICQ-YDYGGSECSA-N
LogP
-0.9
CAS DataBase Reference
53956-04-0
EPA Substance Registry System
.alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-, monoammonium salt (53956-04-0)
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Safety

RIDADR 
UN 3077 9 / PGIII
WGK Germany 
2
RTECS 
LZ6500000
F 
3-10
HS Code 
29389090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL82467
Product name
Glycyrrhizin ammonium salt
Purity
phyproof? Reference Substance
Packaging
100MG
Price
$262
Updated
2024/03/01
Sigma-Aldrich
Product number
1029929
Product name
Ammonium glycyrrhizate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
100mg
Price
$474
Updated
2024/03/01
Sigma-Aldrich
Product number
356780
Product name
Glycyrrhizin, Ammonium Salt - CAS 53956-04-0 - Calbiochem
Packaging
5G
Price
$111
Updated
2022/05/15
TCI Chemical
Product number
G0151
Product name
Monoammonium Glycyrrhizinate Hydrate
Purity
>75.0%(HPLC)
Packaging
1g
Price
$20
Updated
2024/03/01
TCI Chemical
Product number
G0151
Product name
Monoammonium Glycyrrhizinate Hydrate
Purity
>75.0%(HPLC)
Packaging
25g
Price
$65
Updated
2024/03/01
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Glycyrrhizic acid ammonium salt Chemical Properties,Usage,Production

Description

§ 184.1408(a)(1) Licorice (glycyrrhiza) root is the dried and ground rhizome and root portions of Glycyrrhiza glabra or other species of glycyrrhiza. Licorice extract is that portion of the licorice root that is, after maceration, extracted by boiling water. The extract can be further purified by filtration and by treatment with acids and ethyl alcohol. Licorice extract is sold as a liquid paste ("block"), or spraydried powder. (2) Ammoniated glycyrrhizin is prepared from the water extract of licorice root by acid precipitation followed by neutralization with dilute ammonia. Monoammonium glycyrrhizinate (C42H61016NH45H2O ) is prepared from ammoniated glycyrrhizin by solvent extraction and separation techniques.

Chemical Properties

Licorice (glycyrrhiza) root is the dried and ground rhizome and root portions of Glycyrrhiza glabra or other species of glycyrrhiza Ammoniated glycyrrhizin is prepared from the water extract of licorice root by acid precipitation, followed by neutral- ization with dilute ammonia Monoammonium glycyrrhizinate (C42H62O16NH45H2O) is prepared from ammoniated glycyrrhizin by solvent extraction and separation techniques.

Chemical Properties

white to slightly yellow powder

Uses

anti-cancer agent

Uses

pharmaceutical excipient, GRAS, sweetener

Uses

Glycyrrhizic acid ammonium salt is a flavoring and sweetening agent obtained from licorice flavonoids. It has a slight licorice flavor and an intense and rounded sweetness. It is soluble in water, glycerin, and propylene glycol and has good thermal stability but can degrade under prolonged heating. It is stable over a ph of 3.5–9 but could precipitate below ph of 3.5. It can be used in beverages, desserts, confectionary products, soups, and dressings.

Uses

Ammonium Glycyrrhizinate is used in the synthesis of polyion complex nanocarriers which may act as a template for the design of other negatively charged water-soluble drugs. Particularly for anti-infl ammatory drugs with which Ammonium Glycyrrhizinate is associated.

Definition

ChEBI: Monoammonium glycyrrhizinate is an organic molecular entity.

General Description

Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

Biochem/physiol Actions

Biologically active constituent in the sweet root of Glycyrrhiza species (licorice). Antiviral.

Anticancer Research

Glycyrrhizin (GL) is a saponin-like compound that provides the main sweet flavourfor G. glabra (licorice), and it is commonly used in clinical treatment for itsoutstanding pharmacological action such as antitumour, anti-inflammatory andanti-oxidativeactions (Rebhun et al. 2015; Wu et al. 2015). Cai et al. (2017) triedto evaluate the anticancer properties of GA and GL against TNBC in combinationwith etoposide.

Safety Profile

Moderately toxic by intravenous route. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NH3.

target

ROS

Purification Methods

Crystallise the ammonium salt from glacial acetic acid, then dissolve it in ethanolic ammonia and evaporate. The pentahydrate forms needles from 75% aqueous EtOH, m 212-217o. The free acid crystallises from glacial acetic acid. [Karrer et al. Helv Chim Acta 4 100 1921, Lithgoe & Tripett J Chem Soc 1983, 1987 1950, Beilstein 18 IV 5156.]

Glycyrrhizic acid ammonium salt Preparation Products And Raw materials

Raw materials

Glycyrrhizic acid LACQUER THINNER Ammonium hydroxide Triammonium glycyrrhizinate DGL

Preparation Products

Ammonium Glycyrrhizinate
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View Lastest Price from Glycyrrhizic acid ammonium salt manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Glycyrrhizic Acid Ammonium Salt 53956-04-0
Price
US $99.00-35.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-16
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Glycyrrhizic acid ammonium salt 53956-04-0
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
1000kg/month
Release date
2021-12-16
Hebei Weibang Biotechnology Co., Ltd
Product
Glycyrrhizic acid ammonium salt 53956-04-0
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-11

53956-04-0, Glycyrrhizic acid ammonium saltRelated Search:

Ammonium hydroxide Ammonium chloride Ammonium acetate Glycyrrhizic acid Ammonium sulfate Diammonium glycyrrhizinate Shikonin DGL Sodium hyaluronate GLYCYRRHIZIC ACID, MONOAMMONIUM SALT HYDRATE, CA. 75 Ammonium nitrate AMMONIUM GLYCYRRHIZIC ACID, AMMONIUM SALT, TRIHYDRATE(RG) Ammonium Glycyrrhizinate Glycyrrhizic acid ammonium salt GLYCYRRHIZIC ACID AMMONIUM SALT TRIHYDRATE BETA MAX?

  • monoammoniumglycyrrhetat
  • Monoammoniumglycyrrhetate
  • monoammoniumglycyrrhizate
  • (2S,3S,4S,5R,6S)-6-[[(3S,4aS,6aR,6bS,8aR,11S,12aR,14aS,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-5-[(2R,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxy-oxan-2-yl]oxy-3,4-dihydroxyoxane-2-carboxylic acid azane
  • alpha-D-Glucopyranosiduronic acid, (3-beta,20-beta)-20-carboxy-11-oxo-30-norolean-12-en- 3-yl 2-O-beta-D-glucopyranuronosyl-, ammoniate
  • 20β-Carboxy-11-oxo-30-noroleana-12-ene-3β-yl 2-O-(β-D-glucopyranuronosyl)-α-D-glucopyranosiduronic acid/ammonia,(1:x)
  • Glycyrrhizine ammonium salt
  • AMMONIUM 10-[6-CARBOXY-3-(6-CARBOXY-3,4,5-TRIHYDROXY-OXAN-2-YL)OXY-4,5-DIHYDROXY-OXAN-2-YL]OXY-2,4A,6A,6B,9,9,12A-HEPTAMETHYL-13-OXO-3,4,5,6,6A,7,8,8A,10,11,12,14B-DODECAHYDRO-1H-PICENE-2-CARBOXYLATE
  • AMMONIATED GLYCYRRHIZIN
  • 3-O-(2-O-BETA-D-GLUCOPYRANURONOSYL-ALPHA-D-GLUCOPYRANURONOSYL)-18BETA-GLYCYRRHETINIC ACID AMMONIUM SALT
  • GLYCAMIL
  • GLYCYRRHIZIC ACID AMMONIUM SALT
  • GLYCYRRHIZIC ACID, NH4
  • GLYCYRRHIZIC ACID, NH4+
  • GLYCYRRHIZIN AMMONIACAL
  • GLYCYRRHIZIN, AMMONIATED
  • GLYCYRRHIZIN AMMONIUM SALT
  • GLYCYRRHIZIC ACID MONOAMMONIUM SALT
  • GLYCYRRHIZINATE MONOAMMONIUM SALT
  • Glycyrrhizic acid monoammonium salt trihydrate,98%
  • GLYCYRRHIZIC ACID, AMMONIUM SALT(RG)
  • Glycyrrhiz
  • Glycyrrhizic acid, aMMoniuM salt, trihydrate / Glycyrrihizin
  • Glycyrrhizic acid MonoaMMoniuM salt, 98+%
  • Glycyrrhizic acid MonoaMMoniuM salt trihydrate, 98% 25GR
  • aMMoniuM (2S,3S,4S,5R,6S)-5-((2R,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxytetrahydro-2H-pyran-2-yloxy)-6-((3S,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptaMethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydrop
  • Glycyrrhizic Acid Monoammonium Salt Glycyrrhizin Monoammonium Salt
  • Magnasweet
  • MonoaMMoniuM 18β-glycyrrhizinate
  • Monoammonium glycyrrhizinate Glycyrrhizic acid ammonium
  • monoammonium glycyrrhizlnate
  • Monoammonium Glycyrrhizinate EP
  • Glycyrrhizic acid ammonium salt from glycyrrhiza
  • Glycyrrhizic acid ammonium salt 53956-04-0
  • MONOAMMONIATED GLYCYRRHIZINATE
  • MONOAMMONIUM GLYCRRHIZINATE
  • MONOAMMONIUM GLYCYRRHIZINATE
  • .alpha.-D-Glucopyranosiduronicacid,(3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl2-O-.beta.-D-glucopyranuronosyl-,monoammoniumsalt
  • ammoniate
  • Ammoniumglycynhizinato
  • ammoniumglycyrrhizate
  • glycyrram
  • .alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-, monoammonium salt
  • glycyrrhizin monoammonium salt
  • GLYCYRRHIZINICACIDAMMONIUMSALT
  • GLYCERRHIZICACIDMONOAMMONIUMSALT
  • GLYCYRRHIZICAMMONIUM
  • AMMONIUMGLYCYRRHIZIN
  • AMMONIATEDGLYCERRHIZIN
  • (2S,3S,4S,5R,6S)-6-[[(3S,4aS,6aR,6bS,8aR,11S,12aR,14aS,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-5-[(2R,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxy-oxan-2-yl]oxy-3,4-dihydroxy-oxane-2-carboxylic acid
  • MONOAMMONIUM GLYCYRRHIZINATE 95% SODIUM GLYCYRRHIZINTE 95%
  • α-D-Glucopyranosiduronic acid, (3,20)-20-carboxy- 11-oxo-30-norolean-12-en-3-yl 2-O--D-glucopyranuronosyl-, monoammonium salt
  • 3-O-(2-O-β-D-Glucopyranuronosyl-α-D-glucopyranuronosyl)-18β-glycyrrhetinic acid ammonium salt
  • GLYCYRRHIZIN, AMMONIATED [GLYCYRRHIZINIC ACID, MONOAMMONIUM SALT]
  • GLYCYRRHIZIC ACID AMMONIUM
  • GlycyrrhizinicAcidAmmoniumSalt,>95%
  • 3-O-(2-O-beta-D-Glucopyranuronosyl-alpha-D-glucopyranuronosyl)-18beta-g lycyrrhetinic acid ammonium salt
  • AMMONIATED GLYCYRRHIZIN, NATURAL