DROFENINE HYDROCHLORIDE

Product Name: DROFENINE HYDROCHLORIDE
CAS No.: 548-66-3
Chemical Name: DROFENINE HYDROCHLORIDE
Synonyms: it-19;trasentinh;DrofeninHCl;DROFENINE HCL;cyclovegantine;cycloadiphenine;hexahydroadiphenine;Drofeninhydrochlorid;LABOTEST-BB LT00244841;DROFENINE HYDROCHLORIDE
CBNumber: CB1496239
Molecular Formula: C20H32ClNO2
Formula Weight: 353.93
MOL File: 548-66-3.mol

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DROFENINE HYDROCHLORIDE Property

Melting point:: 145-147°
storage temp.: 2-8°C
solubility: Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly)
form: Solid
color: White to Off-White

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Safety

WGK Germany: 2
RTECS: GU6825000
Toxicity: LD50 i.v. in mice: 65.6 mg/kg (Fleisch)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H332Harmful if inhaled

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: D679000
Product name: DrofenineHydrochloride
Packaging: 1g
Price: $1020
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0012869
Product name: DROFENINE HYDROCHLORIDE
Purity: 98.00%
Packaging: 500G
Price: $4866.02
Updated: 2021/12/16

ChemScene

Product number: CS-4885
Product name: Drofeninehydrochloride
Purity: 98.10%
Packaging: 50mg
Price: $100
Updated: 2021/12/16

AK Scientific

Product number: B876
Product name: Drofeninehydrochloride
Packaging: 1g
Price: $127
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0012869
Product name: DROFENINE HYDROCHLORIDE
Purity: 98.00%
Packaging: 10MG
Price: $280.35
Updated: 2021/12/16

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DROFENINE HYDROCHLORIDE Chemical Properties,Usage,Production

Originator

Trasentine A,Ciba

Uses

Spasmolytic

Uses

Drofenine is a widely used anticholinergic drug. It acts on smooth muscle to stop muscle spasms.

Manufacturing Process

17.4 parts of diphenylacetic acid 2-(diethylamino)ethyl ester were solved in 200 parts of acetic acid and hydrogenated over platinum catalyst. After the calculated volume of hydrogen was passed, the catalyst was filtered off and the solvent was removed to dryness. Ether, water and a potassium carbonate solution were added to the remaining oil and were thoroughly shaken. The ether layer was washed with water and dried over potassium carbonate. The solvent was removed, the remaining oil was distilled in vacuum to give 2- (diethylamino)ethyl α-phenylcyclohexaneacetate; BP 150°-160°C/0.2 mm Hg.
In practice it is usually used as hydrochloride.

Therapeutic Function

Spasmolytic

DROFENINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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DROFENINE HYDROCHLORIDE Suppliers

China 46 Germany 2 India 2 Switzerland 1 United Kingdom 1 United States 10 Global 62

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94838
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9551
Advantage: 66

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 0712-0712-2580635 15527768850
Email: 1791901229@qq.com
Country: China
ProdList: 8849
Advantage: 52

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-83725681-603
Fax: +86 755 28094224
Country: China
ProdList: 4505
Advantage: 50

Wuhan Dahua Pharmaceutical Co., Ltd.

Tel: 027-59262863 13277907145 3091977954
Fax: 027-59420980
Country: China
ProdList: 4951
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: QQ:65489617 15618227136
Fax: 21-5161 9052
Email: info@SuperLan-chem.com
Country: China
ProdList: 9445
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29797
Advantage: 68

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.

Tel: 027-51831887 15337167856
Fax: 027-51837635 QQ1165326703
Email: hubeixinyuanshun@163.com
Country: China
ProdList: 10305
Advantage: 58

548-66-3, DROFENINE HYDROCHLORIDERelated Search:

ethyl 2-phenylbutyrate 2-Isopropyl-2-phenylacetic acid ETHYL 2-PHENYLPROPIONATE butetamate METHYL CYCLOHEXANEACETATE ETHYL CYCLOHEXYLACETATE CYCLOHEXYLPHENYLACETIC ACID Cyclohexylacetic acid 2-Phenylbutyric acid 2-DIETHYLAMINOETHANOL HYDROCHLORIDE 2-(diethylamino)ethyl 2-phenylbutyrate hydrochloride DROFENINE HYDROCHLORIDE methyl 2-phenylbutyrate Drofenine Prospasmin 3-METHYL-2-PHENYLVALERIC ACID ACETIC ACID, PHENYL-, 2-(DIETHYLAMINO)ETHYL ESTER 2-(Diethylamino)ethyl alpha-phenyl-beta-methylvalerate hydrochloride

LABOTEST-BB LT00244841

HEXAHYDROADIPHENINE HYDROCHLORIDE

DROFENINE HYDROCHLORIDE

hexahydroadiphenine

DROFENINE HCL

2-(diethylamino)ethylalpha-cyclohexylbenzeneacetate

2-diethylaminoethyl(alpha-phenylcyclohexane)acetatehydrochloride

adipheninehhydrochloride

alpha-cyclohexylbenzeneaceticacid2-(diethylamino)ethylesterhydrochloride

alpha-phenylcyclohexaneaceticacid2-(diethylamino)ethylesterhydrochloride

alpha-phenyl-cyclohexylessigsaeure-2-diaethylamino-aethylester-hydrochlorid

cycloadiphenine

cycloadipheninehydrochloride

cyclohexylphenylacetyldiethylaminoethanolhydrochloride

cyclospasmol(tempelhof)

cyclovegantine

it-19

trasentine-6hhydrochloride

trasentinh

2-(2-cyclohexyl-2-phenylacetoxy)ethyldiethylammonium chloride

2-diethylaminoethyl alpha-cyclohexylphenylacetate hydrochloride

DrofeninHCl

Drofeninhydrochlorid

Drofenine,Cholinesterase (ChE),Drofenine hydrochloride,Inhibitor,inhibit,Hexahydroadiphenine

548-66-3

C20H31NO2HCl

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