DROFENINE HYDROCHLORIDE Property

Melting point:

145-147°

storage temp. 

2-8°C

solubility 

Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly)

form 

Solid

color 

White to Off-White

Safety

WGK Germany 

2

RTECS 

GU6825000

Toxicity

LD50 i.v. in mice: 65.6 mg/kg (Fleisch)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H332Harmful if inhaled

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

DROFENINE HYDROCHLORIDE Chemical Properties,Usage,Production

Originator

Trasentine A,Ciba

Uses

Spasmolytic

Uses

Drofenine is a widely used anticholinergic drug. It acts on smooth muscle to stop muscle spasms.

Manufacturing Process

17.4 parts of diphenylacetic acid 2-(diethylamino)ethyl ester were solved in 200 parts of acetic acid and hydrogenated over platinum catalyst. After the calculated volume of hydrogen was passed, the catalyst was filtered off and the solvent was removed to dryness. Ether, water and a potassium carbonate solution were added to the remaining oil and were thoroughly shaken. The ether layer was washed with water and dried over potassium carbonate. The solvent was removed, the remaining oil was distilled in vacuum to give 2- (diethylamino)ethyl α-phenylcyclohexaneacetate; BP 150°-160°C/0.2 mm Hg.
In practice it is usually used as hydrochloride.

Therapeutic Function

Spasmolytic