ChemicalBook > CAS DataBase List > DROFENINE HYDROCHLORIDE

DROFENINE HYDROCHLORIDE

Product Name
DROFENINE HYDROCHLORIDE
CAS No.
548-66-3
Chemical Name
DROFENINE HYDROCHLORIDE
Synonyms
it-19;trasentinh;DrofeninHCl;DROFENINE HCL;cyclovegantine;cycloadiphenine;hexahydroadiphenine;Drofeninhydrochlorid;LABOTEST-BB LT00244841;DROFENINE HYDROCHLORIDE
CBNumber
CB1496239
Molecular Formula
C20H32ClNO2
Formula Weight
353.93
MOL File
548-66-3.mol
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DROFENINE HYDROCHLORIDE Property

Melting point:
145-147°
storage temp. 
2-8°C
solubility 
Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly)
form 
Solid
color 
White to Off-White
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Safety

WGK Germany 
2
RTECS 
GU6825000
Toxicity
LD50 i.v. in mice: 65.6 mg/kg (Fleisch)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H332Harmful if inhaled

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
D679000
Product name
DrofenineHydrochloride
Packaging
1g
Price
$1020
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0012869
Product name
DROFENINE HYDROCHLORIDE
Purity
98.00%
Packaging
500G
Price
$4866.02
Updated
2021/12/16
ChemScene
Product number
CS-4885
Product name
Drofeninehydrochloride
Purity
98.10%
Packaging
50mg
Price
$100
Updated
2021/12/16
AK Scientific
Product number
B876
Product name
Drofeninehydrochloride
Packaging
1g
Price
$127
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0012869
Product name
DROFENINE HYDROCHLORIDE
Purity
98.00%
Packaging
10MG
Price
$280.35
Updated
2021/12/16
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DROFENINE HYDROCHLORIDE Chemical Properties,Usage,Production

Originator

Trasentine A,Ciba

Uses

Spasmolytic

Uses

Drofenine is a widely used anticholinergic drug. It acts on smooth muscle to stop muscle spasms.

Manufacturing Process

17.4 parts of diphenylacetic acid 2-(diethylamino)ethyl ester were solved in 200 parts of acetic acid and hydrogenated over platinum catalyst. After the calculated volume of hydrogen was passed, the catalyst was filtered off and the solvent was removed to dryness. Ether, water and a potassium carbonate solution were added to the remaining oil and were thoroughly shaken. The ether layer was washed with water and dried over potassium carbonate. The solvent was removed, the remaining oil was distilled in vacuum to give 2- (diethylamino)ethyl α-phenylcyclohexaneacetate; BP 150°-160°C/0.2 mm Hg.
In practice it is usually used as hydrochloride.

Therapeutic Function

Spasmolytic

DROFENINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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DROFENINE HYDROCHLORIDE Suppliers

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548-66-3, DROFENINE HYDROCHLORIDERelated Search:

ethyl 2-phenylbutyrate 2-Isopropyl-2-phenylacetic acid ETHYL 2-PHENYLPROPIONATE butetamate METHYL CYCLOHEXANEACETATE ETHYL CYCLOHEXYLACETATE CYCLOHEXYLPHENYLACETIC ACID Cyclohexylacetic acid 2-Phenylbutyric acid 2-DIETHYLAMINOETHANOL HYDROCHLORIDE 2-(diethylamino)ethyl 2-phenylbutyrate hydrochloride DROFENINE HYDROCHLORIDE methyl 2-phenylbutyrate Drofenine Prospasmin 3-METHYL-2-PHENYLVALERIC ACID ACETIC ACID, PHENYL-, 2-(DIETHYLAMINO)ETHYL ESTER 2-(Diethylamino)ethyl alpha-phenyl-beta-methylvalerate hydrochloride

  • LABOTEST-BB LT00244841
  • HEXAHYDROADIPHENINE HYDROCHLORIDE
  • DROFENINE HYDROCHLORIDE
  • hexahydroadiphenine
  • DROFENINE HCL
  • 2-(diethylamino)ethylalpha-cyclohexylbenzeneacetate
  • 2-diethylaminoethyl(alpha-phenylcyclohexane)acetatehydrochloride
  • adipheninehhydrochloride
  • alpha-cyclohexylbenzeneaceticacid2-(diethylamino)ethylesterhydrochloride
  • alpha-phenylcyclohexaneaceticacid2-(diethylamino)ethylesterhydrochloride
  • alpha-phenyl-cyclohexylessigsaeure-2-diaethylamino-aethylester-hydrochlorid
  • cycloadiphenine
  • cycloadipheninehydrochloride
  • cyclohexylphenylacetyldiethylaminoethanolhydrochloride
  • cyclospasmol(tempelhof)
  • cyclovegantine
  • it-19
  • trasentine-6hhydrochloride
  • trasentinh
  • 2-(2-cyclohexyl-2-phenylacetoxy)ethyldiethylammonium chloride
  • 2-diethylaminoethyl alpha-cyclohexylphenylacetate hydrochloride
  • DrofeninHCl
  • Drofeninhydrochlorid
  • Drofenine,Cholinesterase (ChE),Drofenine hydrochloride,Inhibitor,inhibit,Hexahydroadiphenine
  • 548-66-3
  • C20H31NO2HCl
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