SKI II

Product Name: SKI II
CAS No.: 312636-16-1
Chemical Name: SKI II
Synonyms: SphK-I2;CS-1145;SKI II;SKI-II;SKI II - SKI 2;SKI II (SphK-I2);SKI II USP/EP/BP;SKIII(SphK-I2), >98%;Sphingosine Kinase Inhibitor;Sphingosine Kinase Inhibitor 2;SKI II (Sphingosine Kinase Inhibitor)
CBNumber: CB1498400
Molecular Formula: C15H11ClN2OS
Formula Weight: 302.78
MOL File: 312636-16-1.mol

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SKI II Property

Boiling point:: 507.1±60.0 °C(Predicted)
Density: 1.415±0.06 g/cm3(Predicted)
RTECS: SK5900000
storage temp.: 2-8°C
solubility: DMSO: ≥20 mg/mL
form: solid
pka: 10.17±0.26(Predicted)
color: off-white
Sensitive: Air & Light Sensitive
CAS DataBase Reference: 312636-16-1

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S5696
Product name: SKI II
Purity: ≥98% (HPLC), solid
Packaging: 10mg
Price: $209
Updated: 2024/03/01

Sigma-Aldrich

Product number: S5696
Product name: SKI II
Purity: ≥98% (HPLC), solid
Packaging: 50mg
Price: $639
Updated: 2024/03/01

Alfa Aesar

Product number: J67479
Product name: SKI-II, 98%
Packaging: 10mg
Price: $115
Updated: 2021/12/16

Cayman Chemical

Product number: 10009222
Product name: Sphingosine Kinase Inhibitor 2
Purity: ≥95%
Packaging: 5mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 10009222
Product name: Sphingosine Kinase Inhibitor 2
Purity: ≥95%
Packaging: 10mg
Price: $76
Updated: 2024/03/01

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SKI II Chemical Properties,Usage,Production

Uses

SKI II is a nonlipid inhibitor of sphingosine kinase. SKI II s orally bioavailable and has shown significant inhibition of tumor growth in mice.

Definition

ChEBI: 4-[[4-(4-chlorophenyl)-2-thiazolyl]amino]phenol is a substituted aniline.

Biological Activity

Selective non-lipid inhibitor of sphingosine kinase (IC 50 = 0.5 μ M); does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKC α at concentrations up to 60 μ M. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. Induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC 50 = 0.9-4.6 μ M).

Biochem/physiol Actions

Sphingosine kinase (SK) plays a pivotal role in regulating tumor growth and SK can act as an oncogene. Expression of SK RNA is significantly elevated in a variety of solid tumors, compared with normal tissue from the same patient. A number of novel inhibitors of human SK were identified, and several representative compounds were characterized in detail. These compounds demonstrated activity at sub- to micromolar concentrations, making them more potent than any other reported SK inhibitor, and were selective toward SK compared with a panel of human lipid and protein kinases. Kinetic studies revealed that the compounds were not competitive inhibitors of the ATP-binding site of SK. 4-[4-(4-chloro-phenyl)-thiazol-2-ylamino]-phenol (SKI-II) inhibitor is orally bioavailable, detected in the blood for at least 8 h, and showed a significant inhibition of tumor growth in mice with IC50 = 0.5 μM; SKI II does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKCa at concentrations up to 60 μM.SKI II induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC50 = 0.9-4.6 μM).

storage

Store at -20°C

References

[1] french kj, schrecengost rs, lee bd, zhuang y, smith sn, eberly jl, yun jk, smith cd. discovery and evaluation of inhibitors of human sphingosine kinase. cancer res. 2003 sep 15;63(18):5962-9.

SKI II Preparation Products And Raw materials

Raw materials

Preparation Products

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SKI II Suppliers

China 87 Germany 2 India 2 Switzerland 1 United Kingdom 5 United States 18 Global 115

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View Lastest Price from SKI II manufacturers

Career Henan Chemica Co

Product: SKI II 312636-16-1
Price: US $1.00/g
Min. Order: 1g
Purity: Min98% HPLC/GC
Supply Ability: g/kg/ton Coreychem-Nicole406
Release date: 2020-11-06

312636-16-1, SKI IIRelated Search:

SPHINGOMYELIN 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol Bortezomib Degrasyn (WP1130) LDN-57444 Fingolimod hydrochloride LDN-193189 DBeQ (4-(4-CHLOROPHENYL)(2,5-THIAZOLYL))(4-(TRIFLUOROMETHOXY)PHENYL)AMINE BUTTPARK 4\01-54 SKI II

SKIII(SphK-I2), >98%

SKI II - SKI 2

SPHINGOSINE KINASE INHIBITOR;SPHINGOSINE KINASE INHIBITOR 2;SKI II (SPHK-I2);SPHK-I2;SKI II (SPHINGOSINE KINASE INHIBITOR)

CS-1145

Sphingosine Kinase Inhibitor

Sphingosine Kinase Inhibitor 2

SKI II (SphK-I2)

SphK-I2

SKI II (Sphingosine Kinase Inhibitor)

Phenol, 4-[[4-(4-chlorophenyl)-2-thiazolyl]amino]-

4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol SKI II

4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenol

SKI II;SKI-II

4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino]phenol

SKI II USP/EP/BP

SKI II,Sphingosine kinase,Apoptosis,SphK,Wnt,Inhibitor,inhibit

4-(4-chlorophenyl)-N-(p-tolyl)thiazol-2-amine

312636-16-1

Inhibitors

Lysophospholipid receptor and related