MILRINONE RELATED COMPOUND A (50 MG) (1,6-DIHYDRO-2-METHYL-6-OXO(3,4'-BIPYRIDINE)-5-CAR-BOXAMIDE)

Product Name: MILRINONE RELATED COMPOUND A (50 MG) (1,6-DIHYDRO-2-METHYL-6-OXO(3,4'-BIPYRIDINE)-5-CAR-BOXAMIDE)
CAS No.: 80047-24-1
Chemical Name: MILRINONE RELATED COMPOUND A (50 MG) (1,6-DIHYDRO-2-METHYL-6-OXO(3,4'-BIPYRIDINE)-5-CAR-BOXAMIDE)
Synonyms: Win 47338;Milrinone amide;Milrinone USP RC A;Milrinone Impurity Ⅰ;Milrinone Impurity G;Milrinone ImpuritiesA;Milrinone Related CoMpound A;Milrinone USP Related Compound A;6-Methyl-2-oxo-5-(4-pyridyl)-1H-pyr;Milrinone amide (Milrinone impurity)
CBNumber: CB1500512
Molecular Formula: C12H11N3O2
Formula Weight: 229.23
MOL File: 80047-24-1.mol

More

Less

MILRINONE RELATED COMPOUND A (50 MG) (1,6-DIHYDRO-2-METHYL-6-OXO(3,4'-BIPYRIDINE)-5-CAR-BOXAMIDE) Property

Melting point:: >300 °C (decomp)
Boiling point:: 563.9±50.0 °C(Predicted)
Density: 1.307±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: Aqueous Acid (Very Slightly), DMSO (Very Slightly, Heated, Sonicated), Methanol
form: Solid
pka: 8.65±0.10(Predicted)
color: Pale Yellow
Stability:: Hygroscopic

More

Less

Safety

HS Code: 2933790002

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1443919
Product name: Milrinone Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 50MG
Price: $1250
Updated: 2025/07/31

TRC

Product number: D289445
Product name: 5-DescyanoMilrinone5-Carboxyamide
Packaging: 50mg
Price: $565
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0067033
Product name: 2-METHYL-6-OXO-1,6-DIHYDRO-3,4'-BIPYRIDINE-5-CARBOXAMIDE
Purity: 95.00%
Packaging: 1G
Price: $848.93
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H48-1-5M
Product name: 1,6-Dihydro-2-methyl-6-oxo-[3,4']bipyridin-5-ylcarboxylic acid amide
Purity: 98.0%
Packaging: 250mg
Price: $120
Updated: 2021/12/16

AK Scientific

Product number: 9920AE
Product name: 2-Methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carboxamide
Packaging: 250mg
Price: $177
Updated: 2021/12/16

More

Less

MILRINONE RELATED COMPOUND A (50 MG) (1,6-DIHYDRO-2-METHYL-6-OXO(3,4'-BIPYRIDINE)-5-CAR-BOXAMIDE) Chemical Properties,Usage,Production

Uses

5-Descyano Milrinone 5-Carboxyamide (Milrinone USP Related Compound A) is an impurity of Milrinone (M344680), a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity. Cardiotonic.

Synthesis

78415-72-2

80047-24-1

General procedure for the synthesis of 2-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridyl]-5-carbonitrile from 2-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridyl]-5-carboxamide: Concentrated sulfuric acid (350 μL, 6.3 mmol, 14 equiv) was added to 6-methyl-2-oxo-5-(pyridin-4-yl)-1,2- dihydropyridine-3-carbonitrile (95 mg, 0.450 mmol, 1 eq.) The reaction mixture was heated to 120 °C and maintained for 15 min. Upon completion of the reaction, the mixture was cooled to 0 °C, diluted with water, followed by slow addition of concentrated ammonium hydroxide solution to adjust the pH to 10. The precipitate was collected by filtration and washed with an appropriate amount of water, and dried to afford the target product, 2-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridyl]-5-carboxamide, as a white solid (74 mg, 72% yield).

References

[1] Journal of Medicinal Chemistry, 1986, vol. 29, # 5, p. 635 - 640
[2] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 11, p. 3021 - 3029

MILRINONE RELATED COMPOUND A (50 MG) (1,6-DIHYDRO-2-METHYL-6-OXO(3,4'-BIPYRIDINE)-5-CAR-BOXAMIDE) Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

MILRINONE RELATED COMPOUND A (50 MG) (1,6-DIHYDRO-2-METHYL-6-OXO(3,4'-BIPYRIDINE)-5-CAR-BOXAMIDE) Suppliers

China 57 India 4 Ireland 1 United Kingdom 3 United States 5 Global 70

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18333
Advantage: 56

Nanjing XiZe Biotechnology CO., Ltd.

Tel: 025-58362220 0086-15250997978
Fax: 025-58362220
Email: sale@njxizebio.com
Country: China
ProdList: 4855
Advantage: 55

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 17801761073
Email: 3193328036@qq.com
Country: China
ProdList: 6338
Advantage: 68

Shenzhen SUNGENING Bio-Medical Co., Ltd.

Tel: 0755-0755-28967200-8062 13631290199
Fax: 0755-28967200
Email: wxf@sungening.com
Country: China
ProdList: 9624
Advantage: 60

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

80047-24-1, MILRINONE RELATED COMPOUND A (50 MG) (1,6-DIHYDRO-2-METHYL-6-OXO(3,4'-BIPYRIDINE)-5-CAR-BOXAMIDE)Related Search:

Milrinone Milrinone IMpurity 2 MILBEMECTIN A3 Miconazole EP Impurity E Milbemycin EP Impurity E Milrinone Impurity 14 Milrinone Impurity 17 5-Decyano 5-(Ethyl Formate) Milrinone Miconazole IMpurity I Miconazole IMpurity B 2-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridine]-5-carboxylic acid 1,6-Dihydro-2-(hydroxyMethyl)-6-oxo-[3,4'-bipyridine]-5-carbonitrile Milbemycin oxime Isoconazole Milbemycin EP Impurity D Milrinone Impurity 13 Miconazole Impurity Milrinone Impurity 18

Milrinone Impurit Ⅰ：1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carboxamide

Milrinone Impurity Ⅰ

Milrinone USP Related Compound A

MILRINONE RELATED COMPOUND A (50 MG) (1,6-DIHYDRO-2-METHYL-6-OXO(3,4'-BIPYRIDINE)-5-CAR-BOXAMIDE)

Milrinone amide (Milrinone impurity)

2-METHYL-6-OXO-1,6-DIHYDRO-3,4'-BIPYRIDINE-5-CARBOXAMIDE

1,6-Dihydro-2-methyl-6-oxo-[3,4']bipyridin-5-ylcarboxylic acid amide

Milrinone amide

1,6-Dihydro-2-Methyl-6-oxo(3,4'-bipyridine)-5-carboxaMide

Milrinone Related CoMpound A

Milrinone USP RC A

Milrinone Impurity G

Milrinone Impurity Ⅰ（1,6-Dihydro-2-methyl-6-oxo-（3,4′-bipyridine）-5-carboxamide）

6-Methyl-2-oxo-5-(4-pyridyl)-1H-pyr

[3,4'-Bipyridine]-5-carboxamide, 1,6-dihydro-2-methyl-6-oxo-

Milrinone ImpuritiesA

Milrinone Related Compound A (1,6-Dihydro-2-methyl-6-oxo(3,4''-bipyridine)-5-carboxamide) (1443919)

Milrinone Impurity Ⅰ (1,6-Dihydro-2-methyl-6-oxo- (3,4′-bipyridine) -5-carboxamide)

2-Methyl-6-oxo-1,6-dihydro-[3,4'-bipyridine]-5-carboxamide

Milrinone impurity Ⅰ(1,6-dihydro-2-methyl-6-oxo-(3,4′-bipyridine)-5-amide)

6-Methyl-2-oxo-5-(4-pyridyl)-1H-pyridine-3-carboxamide

Win 47338

2-Methyl-6-oxo-1,6-dihydro-3,4′-bipyridine-5-carboxamide, CAS 80047-24-1

2-Methyl-6-oxo-1,6-dihydro-[3,4'-bipyridine]-5-carboxamide , Milrinone Related Compound A

80047-24-1

Pyridines