2-(3-Bromophenyl)propanoic acid
- Product Name
- 2-(3-Bromophenyl)propanoic acid
- CAS No.
- 53086-52-5
- Chemical Name
- 2-(3-Bromophenyl)propanoic acid
- Synonyms
- 2-M-BROMOPHENYLPROPIONIC ACID;2-(3-bromophenyl)propanoicacid;2-(3-BroMophenyl)Propionic Acid;Benzeneacetic acid, 3-bromo-a-methyl-
- CBNumber
- CB1511774
- Molecular Formula
- C9H9BrO2
- Formula Weight
- 229.07
- MOL File
- 53086-52-5.mol
2-(3-Bromophenyl)propanoic acid Property
- Boiling point:
- 319.6±17.0 °C(Predicted)
- Density
- 1.523±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- solubility
- DCM, DMSO, Diethyl Ether, Methanol
- form
- Solid
- pka
- 4.17±0.10(Predicted)
- color
- White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B619380
- Product name
- 2-(3-Bromophenyl)propanoicAcid
- Packaging
- 25mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- B619380
- Product name
- 2-(3-Bromophenyl)propanoicAcid
- Packaging
- 100mg
- Price
- $395
- Updated
- 2021/12/16
- Product number
- B619380
- Product name
- 2-(3-Bromophenyl)propanoicAcid
- Packaging
- 250mg
- Price
- $790
- Updated
- 2021/12/16
- Product number
- FB141893
- Product name
- 2-(3-Bromophenyl)propanoic acid
- Packaging
- 250mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- FB141893
- Product name
- 2-(3-Bromophenyl)propanoic acid
- Packaging
- 500mg
- Price
- $225
- Updated
- 2021/12/16
2-(3-Bromophenyl)propanoic acid Chemical Properties,Usage,Production
Uses
2-(3-Bromophenyl)propanoic Acid is an intermediate in the synthesis of Ketoprofen (K200800) related compounds.
Synthesis
1878-67-7
74-88-4
53086-52-5
Step 1. 3-Bromophenylacetic acid (1.30 g, 6 mmol) was azeotropized with 2 mL of anhydrous toluene to remove water under nitrogen protection and cooled to room temperature. To this solution was slowly added a THF solution of sodium bis(trimethylmethylsilyl)amide (14 mL, 1N, 14 mmol). After stirring the reaction for 20 minutes at room temperature, iodomethane (0.9 g, 7 mmol) was slowly added dropwise through a constant pressure dropping funnel. After 10 min of reaction, the pH of the reaction solution was adjusted to 2 with 2N HCl solution to quench the reaction. Subsequently, the reaction mixture was extracted with ethyl acetate (EtOAc) and the organic phase was dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated to dryness under reduced pressure. Purification by fast column chromatography (silica gel, eluent gradient: dichloromethane (DCM) to DCM/EtOAc=10:1 to 4:1 to 2:1) afforded the crude 2-(3-bromophenyl)propionic acid (1.13 g, 82% yield) as a colorless oil.
References
[1] Patent: WO2008/39882, 2008, A1. Location in patent: Page/Page column 171
[2] Patent: WO2008/39882, 2008, A1. Location in patent: Page/Page column 171
[3] Patent: US2008/261921, 2008, A1. Location in patent: Page/Page column 110-111
[4] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 23, p. 6447 - 6454
[5] Patent: WO2016/193939, 2016, A1. Location in patent: Page/Page column 41
2-(3-Bromophenyl)propanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2-(3-Bromophenyl)propanoic acid Suppliers
- Tel
- 4009903999 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18729
- Advantage
- 57
- Tel
- 0512-65617459 18915409046
- Fax
- 0512-65617459
- sales@sibian-chem.com
- Country
- China
- ProdList
- 1922
- Advantage
- 55
- Tel
- 18652989687
- Fax
- +86-25-52131256
- sales@norris-pharm.com
- Country
- China
- ProdList
- 8878
- Advantage
- 55
- Tel
- +86-021-50935922
- Fax
- +86-021-33847795
- Country
- China
- ProdList
- 7865
- Advantage
- 55
- Tel
- 18939837085
- Fax
- 2880152141(QQ)
- youchemicals@gmail.com
- Country
- China
- ProdList
- 1839
- Advantage
- 55
- Tel
- 021-021-56795766
- Fax
- +86-21-56795266
- sales@worldyachem.com
- Country
- China
- ProdList
- 9476
- Advantage
- 58
- Tel
- 027-87465837 19945049750
- Fax
- 027-8777-2287
- sales@finetechnology-ind.com
- Country
- China
- ProdList
- 9637
- Advantage
- 58
- Tel
- sales@ahpharmatech.com
- Country
- China
- ProdList
- 5734
- Advantage
- 55
- Tel
- 021-61478794
- Fax
- 021-61478794
- sales@hcshhai.com
- Country
- China
- ProdList
- 9793
- Advantage
- 50
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60