Ethyl 2-chloropyrimidine-5-carboxylate

ChemicalBook > CAS DataBase List > Ethyl 2-chloropyrimidine-5-carboxylate

Ethyl 2-chloropyrimidine-5-carboxylate

Product Name: Ethyl 2-chloropyrimidine-5-carboxylate
CAS No.: 89793-12-4
Chemical Name: Ethyl 2-chloropyrimidine-5-carboxylate
Synonyms: EOS-60350;ETHYL2-CHLOROPYRIMI;2-chloro-pyriMidine-5-carboxylate;Ethyl 2-Chlorpyrimidine-5-carboxylate;2-Chloro-5-(ethoxycarbonyl)pyrimidine;ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE;Ethyl 2-chloropyrimidine-5-carboxylate ,97%;2-chloro-pyrimidine-5-carboxylic acid ethyl ester;PyriMidin-5-carboxylic acid 2-chloro-, ethyl ester;5-PyriMidinecarboxylic acid, 2-chloro-, ethyl ester
CBNumber: CB1547225
Molecular Formula: C7H7ClN2O2
Formula Weight: 186.6
MOL File: 89793-12-4.mol

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Ethyl 2-chloropyrimidine-5-carboxylate Property

Melting point:: 52-60℃
Boiling point:: 80℃/760mm
Density: 1.311±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: soluble in Methanol
pka: -3.05±0.22(Predicted)
form: Solid
color: White to Light yellow
InChI: InChI=1S/C7H7ClN2O2/c1-2-12-6(11)5-3-9-7(8)10-4-5/h3-4H,2H2,1H3
InChIKey: IEMKQRSOAOPKRJ-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(C(OCC)=O)C=N1
CAS DataBase Reference: 89793-12-4

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Safety

Risk Statements: 20/21/22
Safety Statements: 36/37
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: E1250
Product name: Ethyl 2-Chloropyrimidine-5-carboxylate
Purity: >98.0%(GC)
Packaging: 1g
Price: $71
Updated: 2024/03/01

Alfa Aesar

Product number: H64914
Product name: Ethyl 2-chloropyrimidine-5-carboxylate, 97%
Packaging: 1g
Price: $95.65
Updated: 2024/03/01

Alfa Aesar

Product number: H64914
Product name: Ethyl 2-chloropyrimidine-5-carboxylate, 97%
Packaging: 5g
Price: $364.65
Updated: 2024/03/01

Alfa Aesar

Product number: H64914
Product name: Ethyl 2-chloropyrimidine-5-carboxylate, 97%
Packaging: 250mg
Price: $32.1
Updated: 2021/12/16

TRC

Product number: E678415
Product name: Ethyl2-Chlorpyrimidine-5-carboxylate
Packaging: 10g
Price: $825
Updated: 2021/12/16

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Ethyl 2-chloropyrimidine-5-carboxylate Chemical Properties,Usage,Production

Chemical Properties

White to light yellow liquid

Uses

Ethyl 2-chloropyrimidine-5-carboxylate is used in the synthesis of Retinoid x receptor agonists (RXR) that are used in the treatment of cancers.

Synthesis

A mixture of 1,2-Dihydro-2-oxo-5-pyrimidinecarboxylic acid ethyl ester (3.60 g, 21 mmol), phosphorus oxychloride (25 mL), and N, N-dimethylaniline (2.5 mL) was heated to reflux for 1.5 h. After removal of the solvent, ice water (10 mL) was added to the residue. The mixture was added to 2 N NaOH (90 ml) and extracted with EtOAc. After work, the residue was purified by column chromatography on silica gel (ethyl acetate in petroleum ether, 5 per cent v/v) to give the product Ethyl 2-chloropyrimidine-5-carboxylate (1.20 g, 30 per cent).

Ethyl 2-chloropyrimidine-5-carboxylate Preparation Products And Raw materials

Raw materials

Ethyl potassium malonate Ethanol Ethyl 3-ethoxypropionate N,N-Dimethylformamide Ethyl formate Toluene Sodium Phosphorus oxychloride Urea N,N-Dimethylaniline Hydrochloric acid Government regulation Acetic acid Dimethyl sulfate

Preparation Products

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View Lastest Price from Ethyl 2-chloropyrimidine-5-carboxylate manufacturers

Nanjing Fred Technology Co., Ltd

Product: Ethyl 2-chloropyrimidine-5-carboxylate 89793-12-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%HPLC;99%GC
Supply Ability: 1ton
Release date: 2023-11-27

Shaanxi Dideu Medichem Co. Ltd

Product: ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE 89793-12-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-14

Zhuozhou Wenxi import and Export Co., Ltd

Product: ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE 89793-12-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

89793-12-4, Ethyl 2-chloropyrimidine-5-carboxylateRelated Search:

4,6-Dihydroxypyrimidine 2,5-PYRIDINEDICARBOXYLIC ACID 2-Chloropyrimidine 2-Chloropyrimidine-5-carboxylic acid ethyl 2-chloro-4-(1-methylethyl)pyrimidine-5-carboxylate BENZYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE ethyl 2-chloro-4-ethylpyrimidine-5-carboxylate Ethyl 2-chloropyrimidine-5-carboxylate ETHYL 2-CHLORO-4-PHENYLPYRIMIDINE-5-CARBOXYLATE ETHYL-2-CHLORO-4-METHYL-5-PYRIMIDINECARBOXYLATE CYCLOPROPYLMETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE 4-CHLOROBENZYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE ETHYL 2-CHLORO-4-(N-ETHOXYCABONYLETHYL-N-ETHYLAMINO) PYRIMIDINE-5-CARBOXYLATE ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE ethyl 4-tert-butyl-2-chloropyrimidine-5-carboxylate ethyl 2,4-dichloropyrimidine-5-carboxylate

ETHYL2-CHLOROPYRIMI

Ethyl 2-chloropyrimidine-5-carboxylate ,97%

2-chloro-pyrimidine-5-carboxylic acid ethyl ester

2-Chloro-5-(ethoxycarbonyl)pyrimidine

5-PyriMidinecarboxylic acid, 2-chloro-, ethyl ester

ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE

PyriMidin-5-carboxylic acid 2-chloro-, ethyl ester

2-Chloro-5-(ethoxycarbonyl)pyrimidine, 2-Chloro-5-(ethoxycarbonyl)-1,3-diazine

Ethyl 2-Chlorpyrimidine-5-carboxylate

2-chloro-pyriMidine-5-carboxylate

EOS-60350

5-Pyrimidinecarboxylic acid, 2-chloro-, ethyl ester (7CI, 9CI, ACI)

2-chloro-5-Pyrimidinecarboxylic acid ethyl ester (7CI 9CI ACI)

89793-12-4

Heterocycle-Pyrimidine series