1-(5-Nitropyridin-2-yl)piperazine

Product Name: 1-(5-Nitropyridin-2-yl)piperazine
CAS No.: 82205-58-1
Chemical Name: 1-(5-Nitropyridin-2-yl)piperazine
Synonyms: Palbociclib Impurity 43;5-Nitro-2-piperazinopyridine;1-(5-NITROPYRIDIN-2-YL)PIPERAZINE;1-(5-nitro-2-pyridinyl)-piperazine;Piperazine, 1-(5-nitro-2-pyridinyl)-;1-(5-Nitropyridin-2-yl)piperazine95%;1-(5-Nitropyridin-2-yl)piperazine 95%;1-(5-Nitropyridin-2-yl)piperazine - [N93582];1-(5-Nitropyridin-2-yl)piperazine AldrichCPR;1-(5-nitro-2-pyridinyl)piperazine hydrochloride
CBNumber: CB1674419
Molecular Formula: C9H12N4O2
Formula Weight: 208.22
MOL File: 82205-58-1.mol

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1-(5-Nitropyridin-2-yl)piperazine Property

Melting point:: 84-85 °C
Boiling point:: 418.1±40.0 °C(Predicted)
Density: 1.278±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
pka: 8.42±0.10(Predicted)
Appearance: Light yellow to yellow Solid
CAS DataBase Reference: 82205-58-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: N901378
Product name: 1-(5-Nitro-2-pyridinyl)piperazine
Packaging: 2.5g
Price: $90
Updated: 2021/12/16

Matrix Scientific

Product number: 024425
Product name: 1-(5-Nitropyridin-2-yl)piperazine
Packaging: 500mg
Price: $16
Updated: 2021/12/16

Matrix Scientific

Product number: 024425
Product name: 1-(5-Nitropyridin-2-yl)piperazine
Packaging: 1g
Price: $24
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H55-1-W4
Product name: 1-(5-Nitropyridin-2-yl)piperazine
Purity: 95.0%
Packaging: 500mg
Price: $48
Updated: 2021/12/16

AK Scientific

Product number: W8609
Product name: 1-(5-Nitropyridin-2-yl)piperazine
Packaging: 500mg
Price: $71
Updated: 2021/12/16

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1-(5-Nitropyridin-2-yl)piperazine Chemical Properties,Usage,Production

Synthesis

193902-78-2

82205-58-1

Step 2: Synthesis of 1-(5-nitropyridin-2-yl)piperazine (B-3) Compound 1-tert-butylcarbonyl-4-(5-nitro-2-piperidinyl)piperazine (B-2, 19.45 g, 0.0631 mol) was dissolved in dichloromethane (250 mL) and cooled to 0°C. Trifluoroacetic acid (50 mL) was added slowly. The reaction mixture was stirred at room temperature for 16 hours and then concentrated under reduced pressure. The crude product was again dissolved in dichloromethane (250 mL), and the pH was adjusted to alkaline by sequentially adding 1N aqueous NaOH solution (200 mL) and 3N aqueous NaOH solution (100 mL). The organic layer was separated and the aqueous phase was extracted with dichloromethane. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 1-(5-nitropyridin-2-yl)piperazine (B-3, 13.13 g, 100% yield) as a yellow solid. Mass spectrometry (MS) showed the [M + 1] peak as 209.

References

[1] Patent: WO2010/59606, 2010, A2. Location in patent: Page/Page column 182
[2] Patent: WO2011/31628, 2011, A1. Location in patent: Page/Page column 67
[3] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 4, p. 985 - 988
[4] Tetrahedron Letters, 2011, vol. 52, # 45, p. 5905 - 5909
[5] Patent: WO2006/94840, 2006, A1. Location in patent: Page/Page column 43-44

1-(5-Nitropyridin-2-yl)piperazine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(5-Nitropyridin-2-yl)piperazine Suppliers

China 69 France 2 Germany 2 India 3 Russia 1 Switzerland 1 Ukraine 1 United Kingdom 3 United States 19 Global 101

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View Lastest Price from 1-(5-Nitropyridin-2-yl)piperazine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 1-(5-Nitropyridin-2-yl)piperazine 82205-58-1
Price: US $1.00-1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-05-11

Dideu Industries Group Limited

Product: 1-(5-Nitropyridin-2-yl)piperazine 82205-58-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-07

Career Henan Chemical Co

Product: 1-(5-Nitropyridin-2-yl)piperazine 82205-58-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-07-11

82205-58-1, 1-(5-Nitropyridin-2-yl)piperazineRelated Search:

Piperazine 3,5-Dinitrosalicylic acid N-Aminoethylpiperazine 2-Nitrocinnamic acid 1-(3-Nitropyridin-2-yl)piperazine ,97% 1-BOC-4-(3-NITROPYRIDIN-2-YL)PIPERAZINE 1-BENZYL-4-(3-NITROPYRIDIN-2-YL)PIPERAZINE 1-BOC-4-(5-NITRO-2-PYRIDYL)PIPERAZINE 3-METHYL-1-(5-NITROPYRIDIN-2-YL)PIPERAZINE 1-(5-NITROPYRIDIN-2-YL)-PIPERAZINE HYDROCHLORIDE 2-(4-Methylpiperazin-1-yl)-5-nitropyridine 1-METHYL-4-(6-NITROPYRIDIN-3-YL)PIPERAZINE 4-(5-NITRO-PYRIDIN-2-YL)-PIPERAZINE-2-CARBOXYLIC ACID 4-(6-METHYL-5-NITRO-2-PYRIDINYL)-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER 1-(2-Hydroxyethyl)-4-(5-nitropyridin-2-yl)piperazine 1-BOC-4-(6-NITROPYRIDIN-3-YL)PIPERAZINE 1-(6-nitropyridin-3-yl)piperazine 1-(3-Nitropyridin-2-yl)piperazine hydrochloride

1-(5-NITROPYRIDIN-2-YL)PIPERAZINE

1-(5-Nitropyridin-2-yl)piperazine95%

1-(5-Nitropyridin-2-yl)piperazine 95%

5-Nitro-2-piperazinopyridine

1-(5-nitro-2-pyridinyl)-piperazine

1-(5-Nitropyridin-2-yl)piperazine AldrichCPR

1-(5-nitro-2-pyridinyl)piperazine hydrochloride

Palbociclib Impurity 43

1-(5-Nitropyridin-2-yl)piperazine ISO 9001：2015 REACH

Piperazine, 1-(5-nitro-2-pyridinyl)-

1-(5-Nitropyridin-2-yl)piperazine - [N93582]

82205-58-1

pharmacetical

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C9

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