BNP-32 (HUMAN)

Product Name: BNP-32 (HUMAN)
CAS No.: 124584-08-3
Chemical Name: BNP-32 (HUMAN)
Synonyms: BNP HUMAN;Nesiritide;BNP-32 (HUMAN);Nesiritide TFA;BNP (1-32), HUMAN;Nesiritide (BNP-32);Brain natriuretic pe;Nesiritide [USAN:INN];BNP-32 (HUMAN) USP/EP/BP;BNP-32 (human) hydrochloride
CBNumber: CB1676347
Molecular Formula: C143H244N50O42S4
Formula Weight: 3464.05
MOL File: 124584-08-3.mol

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BNP-32 (HUMAN) Property

Density: 1.52±0.1 g/cm3(Predicted)
RTECS: EE1534000
storage temp.: −20°C
form: powder
color: White to off-white
Water Solubility: Soluble in water at 1mg/ml
Sequence: H-Ser-Pro-Lys-Met-Val-Gln-Gly-Ser-Gly-Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser-Gly-Leu-Gly-Cys-Lys-Val-Leu-Arg-Arg-His-OH(Disulfide bridge: Cys10-Cys26)
CAS DataBase Reference: 124584-08-3

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B5900
Product name: Brain Natriuretic Peptide-32 human
Purity: ≥97% (HPLC), powder
Packaging: 0.5mg
Price: $596
Updated: 2024/03/01

Sigma-Aldrich

Product number: B5900
Product name: Brain Natriuretic Peptide-32 human
Purity: ≥97% (HPLC), powder
Packaging: 1mg
Price: $1100
Updated: 2024/03/01

Alfa Aesar

Product number: J66167
Product name: Brain Natriuretic Peptide (1-32), human
Packaging: 1mg
Price: $381
Updated: 2023/06/20

Alfa Aesar

Product number: J66167
Product name: Brain Natriuretic Peptide (1-32), human
Packaging: 0.5mg
Price: $200
Updated: 2021/12/16

Tocris

Product number: 3522
Product name: Brain Natriuretic Peptide (1-32), human
Packaging: 1
Price: $432
Updated: 2021/12/16

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BNP-32 (HUMAN) Chemical Properties,Usage,Production

Description

Nesiritide was introduced in the US as a new intravenous treatment for patients with acutely decompensated congestive heart failure who have dyspnea at rest or with minimal activity. Nesiritide is the first human recombinant form of the potent vasodilatory B-type natriuretic peptide (also known as brain natriuretic peptide), a naturally occurring 32 amino acid peptide with a disulfide-bonded 17 amino acid ring structure. Nesiritide binds to the Atype natriuretic peptide receptor on the surface of endothelial and smooth muscle cells stimulating production of the second messenger cGMP which mediates predominantly vascular smooth muscle cell relaxation. It also facilitates the elimination of sodium and water by the kidney and decreases the secretion of certain hormones, such as adrenalin, angiotensin II, aldosterone and endothelin, which provoke long-term detrimental effects including blood vessel constriction and blood pressure elevation. In clinical trials with heart failure patients, nesidtide dose-dependently reduced pulmonary capillary wedge pressure, right atrial pressure and systemic vascular resistance and increased cardiac index without affecting heart rate. The major adverse effect observed was dose-dependent hypotension. In a phase III comparative trial, nesiritide was found to be superior to iv. nitroglycerine in its haemodynamic effects as well as easier to administer and better tolerated. Nesiritide is cleared by proteolytic cleavage by the enzyme neutral endopeptidase NEP24.11 and by binding to the C-type natriuretic peptide receptor followed by endocytosis and intracellular lysosomal hydrolysis. Since it has a short half-life (18 min), nesiritide is administered as a 21μg/kg bolus infusion followed by a continuous maintenance infusion at 0.011μg/kg/min usually over 24-48 hours.

Originator

Scios (US)

Uses

Brain natriuretic peptide is originally isolated from brain, but is mainly produced in myoendocrine cells of the heart ventricles from which it is released into the circulation. It is involved in blood pressure control and cardiovascular homeostasis.

Uses

Treatment of congestive heart failure (renin-angiotensin system antagonist).

brand name

Natrecor (Biochemie, Austria).

General Description

The gene encoding brain natriuretic peptide-32 (BNP-32) is localized on human chromosome 1p36.22. It is implicated in several biological functions such as diuresis, natriuresis, hypotensive action and inhibition of aldosterone secretion. BNP-32 acts as a potential biomarker of high left ventricular-diastolic pressure in patients with symptomatic left ventricular (LV) dysfunction. Elevated expression of this protein is observed in acute myocardial infarction (AMI) patients.

Biochem/physiol Actions

Brain natriuretic peptide (type B natriuretic peptide) was originally isolated from brain, but is mainly produced in myoendocrine cells of the heart ventricles from which it is released into the circulation. It is involved in blood pressure control and cardiovascular homeostasis.

storage

Store at -20°C

BNP-32 (HUMAN) Preparation Products And Raw materials

Raw materials

Preparation Products

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BNP-32 (HUMAN) Suppliers

China 95 Spain 1 United Kingdom 3 United States 11 USA 1 Global 111

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Alabiochem Tech.Co., Ltd.

Tel: 512-58900862 400-0707518
Fax: 0086-512-56765862
Email: sales@alabiochem.com
Country: China
ProdList: 968
Advantage: 59

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Cellmano Biotech Limited

Tel: 0551-65326643 18156095617
Fax: 0551-65326641
Email: info@cellmano.com
Country: China
ProdList: 1011
Advantage: 55

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Hubei XinyuanShun Chemical Co., Ltd.

Tel: 13971561712, 13995564702, 027-50664929
Fax: 027-50664927
Email: hbeixys2001@163.com
Country: China
ProdList: 3120
Advantage: 55

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View Lastest Price from BNP-32 (HUMAN) manufacturers

Sinoway Industrial co., ltd.

Product: Nesiritide 124584-08-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 20tons
Release date: 2024-06-11

Shandong Huizhihan Supply Chain Co., Ltd

Product: Nesiritide 124584-08-3
Price: US $0.00-0.00/box
Min. Order: 1box
Purity: 99%
Supply Ability: 100
Release date: 2024-10-31

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Nesiritide 124584-08-3
Price: US $0.00/g
Min. Order: 1g
Purity: 98%min
Supply Ability: 1000g
Release date: 2023-01-11

124584-08-3, BNP-32 (HUMAN)Related Search:

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Nesiritide,Brain Natriuretic Peptide-32 human,BNP-32, >98%

BNP-32 (human) hydrochloride

Nesiritide [USAN:INN]

SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH (DISULFIDE BRIDGE: 10-26)

SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS

H-SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS-OH

H-SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS-OH (DISULFIDE BRIDGE: 10-26)

BRAIN NATRIURETIC PEPTIDE (1-32), HUMAN

BRAIN(B-TYPE) NATRIURETIC PEPTIDE-32 (HUMAN)

BRAIN NATRIURETIC PEPTIDE, HUMAN

BRAIN NATRIURETIC PEPTIDE-32 (HUMAN)

B-TYPE (BRAIN) NATRIURETIC PEPTIDE-32 (HUMAN)

BNP HUMAN

BNP-32 (HUMAN)

BNP (1-32), HUMAN

BNP-32 (huMan) Brain Natriuretic Peptide-32 (huMan), Nesiritide

Brain Natriuretic Peptide-32 (huMan), Nesiritide

H-Ser-Pro-Lys-Met-Val-Gln-Gly-Ser-Gly-Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser-Gly-Leu-Gly-Cys-Lys-Val-Leu-Arg-Arg-His-OH Acetate salt (Disulfide bond)

Nesiritide (BNP-32)

Brain Natriuretic Peptide (BNP) (1-32), human

Nesiritide

L-Histidine, L-seryl-L-prolyl-L-lysyl-L-methionyl-L-valyl-L-glutaminylglycyl-L-serylglycyl-L-cysteinyl-L-phenylalanylglycyl-L-arginyl-L-lysyl-L-methionyl-L-α-aspartyl-L-arginyl-L-isoleucyl-L-seryl-L-seryl-L-seryl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-lysyl-L-valyl-L-leucyl-L-arginyl-L-arginyl-,...

BNP-32 (HUMAN) USP/EP/BP

Brain natriuretic pe

124584-08-3 Nesiritide [USAN:INN]

Nesiritide，Brain Natriuretic Peptide-32 human，BNP-32

Nesiritide TFA

L-Histidine, L-seryl-L-prolyl-L-lysyl-L-methionyl-L-valyl-L-glutaminylglycyl-L-serylglycyl-L-cysteinyl-L-phenylalanylglycyl-L-arginyl-L-lysyl-L-methionyl-L-α-aspartyl-L-arginyl-L-isoleucyl-L-seryl-L-seryl-L-seryl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-lysyl-L-valyl-L-leucyl-L-arginyl-L-arginyl-, cyclic (10→26)-disulfide

124584-08-3

C143H224N50O42S4

Peptides

Natriuretic Peptides

Amino Acids and Peptides

BioChemical

Biochemicals and Reagents

Elisa Kit-Mouse Elisa Kit