2,6-Dichloro-3-(trifluoromethyl)pyridine
- Product Name
- 2,6-Dichloro-3-(trifluoromethyl)pyridine
- CAS No.
- 55304-75-1
- Chemical Name
- 2,6-Dichloro-3-(trifluoromethyl)pyridine
- Synonyms
- 2,6-Dichloro-3-[trifluoromethy;2,6-DICHLORO-3-(TRIFLUOROMETHYL)PYRIDIN&;2,6-DICHLORO-3-(TRIFLUOROMETHYL)PYRIDINE;Pyridine, 2,6-dichloro-3-(trifluoromethyl)-;2,6-Dichloro-3-(trifluoromethyl)pyridine,97%;2,6-DICHLORO-3-[TRIFLUOROMETHYL]-PYRIDINE 99+%;2,6-Dichloro-3-(trifluoromethyl)pyridine - [D4528];2,6-Dichloro-alpha,alpha,alpha-trifluoro-3-picoline;2,6-DICHLORO-3-(TRIFLUOROMETHYL)PYRIDINE, PURISS, 98%;2,6-Dichloro-3-(trifluoromethyl)pyridine ISO 9001：2015 REACH
- CBNumber
- CB1687594
- Molecular Formula
- C6H2Cl2F3N
- Formula Weight
- 215.99
- MOL File
- 55304-75-1.mol
2,6-Dichloro-3-(trifluoromethyl)pyridine Property
- Melting point:
- 194 °C
- Boiling point:
- 194-196 °C(lit.)
- Density
- 2.008 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.4850(lit.)
- Flash point:
- 218 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- -4.84±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
- BRN
- 1570287
- InChI
- InChI=1S/C6H2Cl2F3N/c7-4-2-1-3(5(8)12-4)6(9,10)11/h1-2H
- InChIKey
- UPWAAFFFSGQECJ-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(Cl)=CC=C1C(F)(F)F
- CAS DataBase Reference
- 55304-75-1(CAS DataBase Reference)
Safety
- Hazard Codes
- T,Xi
- Risk Statements
- 25-36/37/38
- Safety Statements
- 26-36/37-45
- RIDADR
- UN 2810 6.1/PG 3
- WGK Germany
- 3
- Hazard Note
- Harmful/Irritant
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 648884
- Product name
- 2,6-Dichloro-3-(trifluoromethyl)pyridine
- Purity
- 98%
- Packaging
- 250mg
- Price
- $39.9
- Updated
- 2022/05/15
- Product number
- D437208
- Product name
- 2,6-Dichloro-3-(trifluoromethyl)pyridine
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- D437208
- Product name
- 2,6-Dichloro-3-(trifluoromethyl)pyridine
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FD105535
- Product name
- 2,6-dichloro-3-(trifluoromethyl)pyridine
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- J91648
- Product name
- 2,6-Dichloro-3-trifluoromethylpyridine
- Packaging
- 10g
- Price
- $75
- Updated
- 2021/12/16
2,6-Dichloro-3-(trifluoromethyl)pyridine Chemical Properties,Usage,Production
Chemical Properties
Colorless liquid
Uses
2,6-Dichloro-3-(trifluoromethyl)pyridine is a fluorine-containing pyridine derivative that can be used in cross-coupling reactions of polyhalogenated heterocycles and in the preparation of other aryl pyridines.
Synthesis
81290-20-2
148493-37-2
55304-75-1
The general procedure for the synthesis of 2,6-dichloro-3-(trifluoromethyl)pyridine from (trifluoromethyl)trimethylsilane and 2,6-dichloro-3-iodopyridine is as follows: Step 1: Potassium fluoride (2.24 g, 38.5 mmol) and copper(I) iodide (7.33 g, 38.5 mmol) were weighed in a flask and the mixture was heated using a gas burner while gently shaking under high vacuum until the contents changed to light yellowish green color. After cooling to room temperature, anhydrous N,N-dimethylformamide (50 mL) and anhydrous tetrahydrofuran (10 mL) were added, followed by trimethyl(trifluoromethyl)silane (5.5 mL, 35 mmol). The mixture was heated to 50 °C and stirred for 21 hours. A mixed solution of 2,6-dichloro-3-iodopyridine (9.59 g, 35.0 mmol) in anhydrous N,N-dimethylformamide (10 mL) and anhydrous tetrahydrofuran (20 mL) was added dropwise at 50 °C to the above reaction mixture. After continuing to stir at 50 °C for 21 hours, trimethyl(trifluoromethyl)silane (0.55 mL, 3.5 mmol) was added and the mixture was stirred for 24 hours. After completion of the reaction, the reaction mixture was cooled to room temperature, poured into 12% ammonia and the mixture was extracted with ether three times. The combined organic layers were washed sequentially with 12% ammonia, 1 M hydrochloric acid, saturated aqueous sodium bicarbonate and saturated brine, dried with anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: dichloromethane:hexane=1:4) to afford 2,6-dichloro-3-(trifluoromethyl)pyridine (7.32 g, 97.3% yield).
References
[1] Patent: WO2009/145360, 2009, A1. Location in patent: Page/Page column 111-112
2,6-Dichloro-3-(trifluoromethyl)pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-Dichloro-3-(trifluoromethyl)pyridine manufacturers
- Product
- 2,6-Dichloro-3-(trifluoromethyl) pyridine 55304-75-1
- Price
- US $2800.00/Kg
- Min. Order
- 0.100Kg
- Purity
- 98
- Supply Ability
- 5000 Kg
- Release date
- 2025-04-29
- Product
- 2,6-Dichloro-3-(trifluoromethyl)pyridine 55304-75-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-27
- Product
- 2,6-Dichloro-3-(trifluoromethyl)pyridine 55304-75-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 500kg/month
- Release date
- 2019-08-01