2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile
- Product Name
- 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile
- CAS No.
- 13600-42-5
- Chemical Name
- 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile
- Synonyms
- 3-Cyano-2,6-dichloro-4-(trifluoromethyl)pyridine, 2,6-Dichloro-4-(trifluoromethyl)pyridine-3-carbonitrile;BUTTPARK 43\57-39;IFLAB-BB F2108-0099;2,6-Dichloro-4-(Trifluoromethy;,6-Dichloro-4-(trifluoromethyl)nicotinonitrile;2,6-DICHLORO-4-(TRIFLUOROMETHYL)NICOTINONITRILE;3-Cyano-2,6-dichloro-4-(trifluoomethyl)pyridine;3-CYANO-2,6-DICHLORO-4-(TRIFLUOROMETHYL)PYRIDINE;2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile 98%;3-Cyano-2,6-dichloro-4-(trifluoromethyl)pyridine98%
- CBNumber
- CB9351572
- Molecular Formula
- C7HCl2F3N2
- Formula Weight
- 241
- MOL File
- 13600-42-5.mol
2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile Property
- Melting point:
- 38 °C
- Boiling point:
- 282.4±35.0 °C(Predicted)
- Density
- 1.63±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- crystals
- pka
- -6.82±0.10(Predicted)
- color
- Colourless
- CAS DataBase Reference
- 13600-42-5(CAS DataBase Reference)
Safety
- Hazard Codes
- T,Xi,Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 22-26-36/37/39
- RIDADR
- 3439
- HazardClass
- TOXIC
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C978900
- Product name
- 3-Cyano-2,6-dichloro-4-trifluoromethylpyridine
- Packaging
- 10g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- C978900
- Product name
- 3-Cyano-2,6-dichloro-4-trifluoromethylpyridine
- Packaging
- 25g
- Price
- $275
- Updated
- 2021/12/16
- Product number
- C978900
- Product name
- 3-Cyano-2,6-dichloro-4-trifluoromethylpyridine
- Packaging
- 50g
- Price
- $495
- Updated
- 2021/12/16
- Product number
- FC55196
- Product name
- 3-Cyano-2,6-dichloro-4-(trifluoromethyl)pyridine
- Packaging
- 10g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- PC2101D
- Product name
- 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile
- Purity
- 97%
- Packaging
- 25g
- Price
- $263
- Updated
- 2021/12/16
2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile Chemical Properties,Usage,Production
Chemical Properties
yellow powder
Uses
3-Cyano-2,6-dichloro-4-trifluoromethylpyridine is used as a reagent in the synthesis of cyano(trifluoromethyl)aminopyridine derivatives which are used as androgen receptor antagonists for stimulating hair growth and reducing sebum production. 3-Cyano-2,6-dichloro-4-trifluoromethylpyridine is also used in the preparation of novel analogs of marine indole alkaloids which are used as potential anticancer agents.
Synthesis
3335-46-4
13600-42-5
GENERAL STEPS: In a 500 mL round bottom flask, 84.5 g (414 mmol) of 2,6-dihydroxy-3-cyano-4-(trifluoromethyl)pyridine, 400 g of phosphoryl chloride and 35 g of catalyst were added. The mixture was heated and refluxed for 20 h, during which the progress of the reaction was monitored by TLC. Upon completion of the reaction, the reflux unit was changed to a distillation unit to evaporate the excess phosphorus trichloride. The reaction mixture was slowly poured into an ice-water mixture and a white solid was precipitated. The solid was collected by filtration and dried to give 79.6 g of the target product 2,6-dichloro-3-cyano-4-(trifluoromethyl)pyridine in 79.78% yield.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 4, p. 475 - 477
[2] Patent: CN107382848, 2017, A. Location in patent: Paragraph 0043; 0046-0047
2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile manufacturers
- Product
- 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile 13600-42-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-12
- Product
- 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile 13600-42-5
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2021-10-15
- Product
- 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile 13600-42-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2019-12-30