2-Chloro-4-methylpyridine-3-carbonitrile
- Product Name
- 2-Chloro-4-methylpyridine-3-carbonitrile
- CAS No.
- 65169-38-2
- Chemical Name
- 2-Chloro-4-methylpyridine-3-carbonitrile
- Synonyms
- 2-chloro-4-methylnicotinonitrile;2-Chloro-4-methyl-3-cyano-pyridine;2-Chloro-4-methylpyridine-3-carbonitrile;2-chloro-4-methyl-3-pyridinecarbonitrile;3-Pyridinecarbonitrile, 2-chloro-4-methyl-;_x000D_2-Chloro-4-methylpyridine-3-carbonitrile;2-Chloro-4-methylpyridine-3-carbonitrile ISO 9001：2015 REACH
- CBNumber
- CB11457082
- Molecular Formula
- C7H5ClN2
- Formula Weight
- 152.58
- MOL File
- 65169-38-2.mol
2-Chloro-4-methylpyridine-3-carbonitrile Property
- Melting point:
- 108-109°
- storage temp.
- Inert atmosphere,Room Temperature
- form
- solid
- color
- Light brown to brown
- InChI
- InChI=1S/C7H5ClN2/c1-5-2-3-10-7(8)6(5)4-9/h2-3H,1H3
- InChIKey
- BXUFVXSRHLSIMN-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC(C)=C1C#N
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C991400
- Product name
- 2-Chloro-4-methylpyridine-3-carbonitrile
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 058874
- Product name
- 2-Chloro-4-methyl-nicotinonitrile
- Purity
- 95+%
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 9970AB
- Product name
- 2-Chloro-4-methylnicotinonitrile
- Packaging
- 250mg
- Price
- $117
- Updated
- 2021/12/16
- Product number
- 058874
- Product name
- 2-Chloro-4-methyl-nicotinonitrile
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 049163
- Product name
- 2-Chloro-4-methyl-nicotinonitrile
- Purity
- 97%
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
2-Chloro-4-methylpyridine-3-carbonitrile Chemical Properties,Usage,Production
Synthesis
93271-59-1
65169-38-2
General procedure for the synthesis of 2-chloro-3-cyano-4-methylpyridine from 3-cyano-4-methyl-2-pyridone: (c) Preparation of 2-chloro-3-cyano-4-methylpyridine (chlorination) 4-Methyl-3-cyano-2-pyridone (40.7 g, 0.304 mol) was added to a stirred mixed solution of phosphorus trichloride (POCL3, 140 g, 0.912 mol) and phosphorus pentachloride (PCl5, 19.0 g, 0.091 mol). The reaction mixture was heated to reflux (about 115 °C) and maintained at this temperature for 2 hours of reaction. Upon completion of the reaction, the excess phosphorous trichloride was removed by distillation. After the reaction mixture was cooled to room temperature, it was quenched by slowly adding water (30 mL). The aqueous phase was extracted with dichloromethane (30 mL), and the organic phases were combined and concentrated to give 43.2 g of a tan solid, which was identified as 2-chloro-3-cyano-4-methylpyridine (4). The melting point was 102-104 °C. The yield was 98.2%. 1H NMR (CDCl3): δ 8.03 (d, J = 2 Hz, 1H), 7.6 (d, J = 2 Hz, 1H), 2.5 (s, 3H). 13C NMR (CDCl3): δ 156.1, 152.6, 151.8, 124.9, 114.4, 111.8, 20.6; δ 156.1, 152.6, 151.8, 124.9, 114.4, 111.8, 20.6. FTIR (KBr, cm-1): 3144, 2979, 2834, 2228, 1653, 1616, 1540, 1484, 1242, 1218, 1173, 819, 607.
References
[1] Patent: US2002/52507, 2002, A1
[2] Patent: EP1679003, 2006, A1. Location in patent: Page/Page column 22
2-Chloro-4-methylpyridine-3-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-4-methylpyridine-3-carbonitrile manufacturers
- Product
- 2-Chloro-4-methylpyridine-3-carbonitrile 65169-38-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-25
- Product
- 2-Chloro-4-methylpyridine-3-carbonitrile 65169-38-2
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-08