ChemicalBook > CAS DataBase List > 2-Chloro-4-methylpyridine-3-carbonitrile

2-Chloro-4-methylpyridine-3-carbonitrile

Product Name
2-Chloro-4-methylpyridine-3-carbonitrile
CAS No.
65169-38-2
Chemical Name
2-Chloro-4-methylpyridine-3-carbonitrile
Synonyms
2-chloro-4-methylnicotinonitrile;2-Chloro-4-methyl-3-cyano-pyridine;2-Chloro-4-methylpyridine-3-carbonitrile;2-chloro-4-methyl-3-pyridinecarbonitrile;3-Pyridinecarbonitrile, 2-chloro-4-methyl-;_x000D_2-Chloro-4-methylpyridine-3-carbonitrile;2-Chloro-4-methylpyridine-3-carbonitrile ISO 9001：2015 REACH
CBNumber
CB11457082
Molecular Formula
C7H5ClN2
Formula Weight
152.58
MOL File
65169-38-2.mol
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2-Chloro-4-methylpyridine-3-carbonitrile Property

Melting point:
108-109°
storage temp. 
Inert atmosphere,Room Temperature
form 
solid
color 
Light brown to brown
InChI
InChI=1S/C7H5ClN2/c1-5-2-3-10-7(8)6(5)4-9/h2-3H,1H3
InChIKey
BXUFVXSRHLSIMN-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=CC(C)=C1C#N
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Safety

HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C991400
Product name
2-Chloro-4-methylpyridine-3-carbonitrile
Packaging
500mg
Price
$175
Updated
2021/12/16
Matrix Scientific
Product number
058874
Product name
2-Chloro-4-methyl-nicotinonitrile
Purity
95+%
Packaging
250mg
Price
$50
Updated
2021/12/16
Oakwood
Product number
049163
Product name
2-Chloro-4-methyl-nicotinonitrile
Purity
97%
Packaging
250mg
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
058874
Product name
2-Chloro-4-methyl-nicotinonitrile
Purity
95+%
Packaging
1g
Price
$100
Updated
2021/12/16
AK Scientific
Product number
9970AB
Product name
2-Chloro-4-methylnicotinonitrile
Packaging
250mg
Price
$117
Updated
2021/12/16
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2-Chloro-4-methylpyridine-3-carbonitrile Chemical Properties,Usage,Production

Synthesis

93271-59-1

65169-38-2

General procedure for the synthesis of 2-chloro-3-cyano-4-methylpyridine from 3-cyano-4-methyl-2-pyridone: (c) Preparation of 2-chloro-3-cyano-4-methylpyridine (chlorination) 4-Methyl-3-cyano-2-pyridone (40.7 g, 0.304 mol) was added to a stirred mixed solution of phosphorus trichloride (POCL3, 140 g, 0.912 mol) and phosphorus pentachloride (PCl5, 19.0 g, 0.091 mol). The reaction mixture was heated to reflux (about 115 °C) and maintained at this temperature for 2 hours of reaction. Upon completion of the reaction, the excess phosphorous trichloride was removed by distillation. After the reaction mixture was cooled to room temperature, it was quenched by slowly adding water (30 mL). The aqueous phase was extracted with dichloromethane (30 mL), and the organic phases were combined and concentrated to give 43.2 g of a tan solid, which was identified as 2-chloro-3-cyano-4-methylpyridine (4). The melting point was 102-104 °C. The yield was 98.2%. 1H NMR (CDCl3): δ 8.03 (d, J = 2 Hz, 1H), 7.6 (d, J = 2 Hz, 1H), 2.5 (s, 3H). 13C NMR (CDCl3): δ 156.1, 152.6, 151.8, 124.9, 114.4, 111.8, 20.6; δ 156.1, 152.6, 151.8, 124.9, 114.4, 111.8, 20.6. FTIR (KBr, cm-1): 3144, 2979, 2834, 2228, 1653, 1616, 1540, 1484, 1242, 1218, 1173, 819, 607.

References

[1] Patent: US2002/52507, 2002, A1
[2] Patent: EP1679003, 2006, A1. Location in patent: Page/Page column 22

2-Chloro-4-methylpyridine-3-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-4-methylpyridine-3-carbonitrile Suppliers

China 86 France 1 Germany 1 India 1 United Kingdom 1 United States 11 Global 101
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View Lastest Price from 2-Chloro-4-methylpyridine-3-carbonitrile manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-Chloro-4-methylpyridine-3-carbonitrile 65169-38-2
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-25
Career Henan Chemical Co
Product
2-Chloro-4-methylpyridine-3-carbonitrile 65169-38-2
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-08

65169-38-2, 2-Chloro-4-methylpyridine-3-carbonitrileRelated Search:

2-Chloro-3-cyanopyridine 2,4,6-Collidine 3-Cyanopyridine 2-Chloro-5-chloromethylpyridine 4-Methylpyridine 2-Chloro-4-picoline 3-Cyano-4-methylpyridine 2,6-Lutidine Azamethiphos 2-CYANO-4-METHYLPYRIDINE 2-Chloro-3-picoline ETHYL 2-CHLORO-3-CYANO-6-METHYLISONICOTINATE PYRIDINITRIL 2,6-Dichloro-4-methylnicotinonitrile 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile 2-Chloro-3-cyano-4,6-dimethylpyridine 2-CHLORO-6-METHYLPYRIDINE-3-CARBONITRILE Difluorochloromethane

  • 2-chloro-4-methyl-3-pyridinecarbonitrile
  • 2-Chloro-4-methylpyridine-3-carbonitrile
  • 2-chloro-4-methylnicotinonitrile
  • 2-Chloro-4-methyl-3-cyano-pyridine
  • 3-Pyridinecarbonitrile, 2-chloro-4-methyl-
  • 2-Chloro-4-methylpyridine-3-carbonitrile ISO 9001：2015 REACH
  • _x000D_2-Chloro-4-methylpyridine-3-carbonitrile
  • 65169-38-2
  • Boron, Nitrile, Thio,& TM-Cpds
  • Heterocycles
  • Pyridine