ChemicalBook > CAS DataBase List > 2,6-Dichloro-3-(trifluoromethyl)pyridine

2,6-Dichloro-3-(trifluoromethyl)pyridine

Product Name
2,6-Dichloro-3-(trifluoromethyl)pyridine
CAS No.
55304-75-1
Chemical Name
2,6-Dichloro-3-(trifluoromethyl)pyridine
Synonyms
2,6-Dichloro-3-[trifluoromethy;2,6-DICHLORO-3-(TRIFLUOROMETHYL)PYRIDIN&;2,6-DICHLORO-3-(TRIFLUOROMETHYL)PYRIDINE;Pyridine, 2,6-dichloro-3-(trifluoromethyl)-;2,6-Dichloro-3-(trifluoromethyl)pyridine,97%;2,6-DICHLORO-3-[TRIFLUOROMETHYL]-PYRIDINE 99+%;2,6-Dichloro-3-(trifluoromethyl)pyridine - [D4528];2,6-Dichloro-alpha,alpha,alpha-trifluoro-3-picoline;2,6-DICHLORO-3-(TRIFLUOROMETHYL)PYRIDINE, PURISS, 98%;2,6-Dichloro-3-(trifluoromethyl)pyridine ISO 9001：2015 REACH
CBNumber
CB1687594
Molecular Formula
C6H2Cl2F3N
Formula Weight
215.99
MOL File
55304-75-1.mol
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2,6-Dichloro-3-(trifluoromethyl)pyridine Property

Melting point:
194 °C
Boiling point:
194-196 °C(lit.)
Density 
2.008 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.4850(lit.)
Flash point:
218 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
-4.84±0.10(Predicted)
Appearance
Colorless to light yellow Liquid
BRN 
1570287
InChI
InChI=1S/C6H2Cl2F3N/c7-4-2-1-3(5(8)12-4)6(9,10)11/h1-2H
InChIKey
UPWAAFFFSGQECJ-UHFFFAOYSA-N
SMILES
C1(Cl)=NC(Cl)=CC=C1C(F)(F)F
CAS DataBase Reference
55304-75-1(CAS DataBase Reference)
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Safety

Hazard Codes 
T,Xi
Risk Statements 
25-36/37/38
Safety Statements 
26-36/37-45
RIDADR 
UN 2810 6.1/PG 3
WGK Germany 
3
Hazard Note 
Harmful/Irritant
HazardClass 
6.1
PackingGroup 
III
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
648884
Product name
2,6-Dichloro-3-(trifluoromethyl)pyridine
Purity
98%
Packaging
250mg
Price
$39.9
Updated
2022/05/15
TRC
Product number
D437208
Product name
2,6-Dichloro-3-(trifluoromethyl)pyridine
Packaging
250mg
Price
$55
Updated
2021/12/16
TRC
Product number
D437208
Product name
2,6-Dichloro-3-(trifluoromethyl)pyridine
Packaging
500mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD105535
Product name
2,6-dichloro-3-(trifluoromethyl)pyridine
Packaging
1g
Price
$60
Updated
2021/12/16
AK Scientific
Product number
J91648
Product name
2,6-Dichloro-3-trifluoromethylpyridine
Packaging
10g
Price
$75
Updated
2021/12/16
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2,6-Dichloro-3-(trifluoromethyl)pyridine Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid

Uses

2,6-Dichloro-3-(trifluoromethyl)pyridine is a fluorine-containing pyridine derivative that can be used in cross-coupling reactions of polyhalogenated heterocycles and in the preparation of other aryl pyridines.

Synthesis

81290-20-2

148493-37-2

55304-75-1

The general procedure for the synthesis of 2,6-dichloro-3-(trifluoromethyl)pyridine from (trifluoromethyl)trimethylsilane and 2,6-dichloro-3-iodopyridine is as follows: Step 1: Potassium fluoride (2.24 g, 38.5 mmol) and copper(I) iodide (7.33 g, 38.5 mmol) were weighed in a flask and the mixture was heated using a gas burner while gently shaking under high vacuum until the contents changed to light yellowish green color. After cooling to room temperature, anhydrous N,N-dimethylformamide (50 mL) and anhydrous tetrahydrofuran (10 mL) were added, followed by trimethyl(trifluoromethyl)silane (5.5 mL, 35 mmol). The mixture was heated to 50 °C and stirred for 21 hours. A mixed solution of 2,6-dichloro-3-iodopyridine (9.59 g, 35.0 mmol) in anhydrous N,N-dimethylformamide (10 mL) and anhydrous tetrahydrofuran (20 mL) was added dropwise at 50 °C to the above reaction mixture. After continuing to stir at 50 °C for 21 hours, trimethyl(trifluoromethyl)silane (0.55 mL, 3.5 mmol) was added and the mixture was stirred for 24 hours. After completion of the reaction, the reaction mixture was cooled to room temperature, poured into 12% ammonia and the mixture was extracted with ether three times. The combined organic layers were washed sequentially with 12% ammonia, 1 M hydrochloric acid, saturated aqueous sodium bicarbonate and saturated brine, dried with anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: dichloromethane:hexane=1:4) to afford 2,6-dichloro-3-(trifluoromethyl)pyridine (7.32 g, 97.3% yield).

References

[1] Patent: WO2009/145360, 2009, A1. Location in patent: Page/Page column 111-112

2,6-Dichloro-3-(trifluoromethyl)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2,6-Dichloro-3-(trifluoromethyl)pyridine Suppliers

Canada 2 China 124 France 1 Germany 3 India 3 Switzerland 1 The Netherlands 1 United Kingdom 7 United States 27 Global 169
Carbosynth
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Fluorochem Ltd
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View Lastest Price from 2,6-Dichloro-3-(trifluoromethyl)pyridine manufacturers

R&D Scientific Inc.
Product
2,6-Dichloro-3-(trifluoromethyl) pyridine 55304-75-1
Price
US $2800.00/Kg
Min. Order
0.100Kg
Purity
98
Supply Ability
5000 Kg
Release date
2025-04-29
Dideu Industries Group Limited
Product
2,6-Dichloro-3-(trifluoromethyl)pyridine 55304-75-1
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-27
Career Henan Chemical Co
Product
2,6-Dichloro-3-(trifluoromethyl)pyridine 55304-75-1
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
500kg/month
Release date
2019-08-01

55304-75-1, 2,6-Dichloro-3-(trifluoromethyl)pyridineRelated Search:

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