ChemicalBook > CAS DataBase List > EIPA

EIPA

Product Name: EIPA
CAS No.: 1154-25-2
Chemical Name: EIPA
Synonyms: ethylisopropylamiloride;EIPA;MH 12-43;L 593754;EIPA (L593754);EIPA, 10 mM in DMSO;Ethylisopropylamiloride (EIPA);5-(N-ETHYL-N-ISOPROPYL)AMILORIDE;AMILORIDE, 5-(N-ETHYL-N-ISOPROPYL)-;Amiloride,5-(N-Ethyl-N-isopropyl)-[5-(N-Ethyl-N-isopropyl)amiloride
CBNumber: CB1706411
Molecular Formula: C11H18ClN7O
Formula Weight: 299.76
MOL File: 1154-25-2.mol

Less

EIPA Property

Melting point:: 202-205 °C(lit.)
Density: 1.49±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: Acetonitrile (Slightly, Heated), DMSO (Slightly), Methanol (Slightly)
form: Off-white to yellow solid.
pka: 8.67±0.46(Predicted)
color: Pale Yellow to Green
biological source: synthetic
Stability:: Unstable in methanol
InChI: InChI=1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)
InChIKey: QDERNBXNXJCIQK-UHFFFAOYSA-N
SMILES: C1(C(NC(N)=N)=O)=NC(Cl)=C(N(CC)C(C)C)N=C1N
CAS DataBase Reference: 1154-25-2

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
RIDADR: 2811
WGK Germany: 3
HazardClass: 6.1(b)
PackingGroup: III

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A3085
Product name: 5-(N-Ethyl-N-isopropyl)amiloride
Packaging: 25mg
Price: $240
Updated: 2025/07/31

Sigma-Aldrich

Product number: A3085
Product name: 5-(N-Ethyl-N-isopropyl)amiloride
Packaging: 100mg
Price: $795
Updated: 2025/07/31

Cayman Chemical

Product number: 14406
Product name: 5-(N-ethyl-N-isopropyl)-Amiloride
Purity: ≥98%
Packaging: 5mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 14406
Product name: 5-(N-ethyl-N-isopropyl)-Amiloride
Purity: ≥98%
Packaging: 10mg
Price: $107
Updated: 2024/03/01

Cayman Chemical

Product number: 14406
Product name: 5-(N-ethyl-N-isopropyl)-Amiloride
Purity: ≥98%
Packaging: 25mg
Price: $179
Updated: 2024/03/01

Less

EIPA Chemical Properties,Usage,Production

Description

Sodium-hydrogen exchangers (NHE) are involved in maintaining sodium and pH balance in a variety of tissues. They are also known as sodium-hydrogen antiporters and solute carrier family 9 members. 5-(N-ethyl-N-isopropyl)-Amiloride (EIPA) is a potent inhibitor of several NHE isoforms, inhibiting NHE1, NHE2, NHE3, and NHE5 with K_i values of 0.02, 0.5, 2.4, and 0.42 μM, respectively. It less effectively inhibits NHE4 (IC₅₀ ≥10 μM). EIPA is commonly used at a concentration of 5-10 μM to inhibit cellular HNE activity.

Chemical Properties

Yellow Solid

Uses

Selective Na+/H+ antiporter inhibitor. Selectively enhances the excretion of sodium ions without causing an increase in excretion of potassium ions.

Uses

5-(N-Ethyl-N-isopropyl)amiloride has been used:

as a supplement in endothelial cell growth medium to incubate human lung microvascular endothelial cell
in Pluronic F-127 stock solution for Drosophila larval live-imaging
in choline chloride solution as an experimental perfusate, to study the effect of Na⁺/H⁺ inhibition on jejunal loop perfusion in vivo

Definition

ChEBI: Ethylisopropylamiloride is a member of the class of pyrazines that is amiloride in which the amino substitutent of the pyrazine ring that is adjacent to the chloro substituent has been substituted by an ethyl group and by an isopropyl group. It has a role as an anti-arrhythmia drug, a neuroprotective agent and a sodium channel blocker. It is a member of guanidines, an aromatic amine, an organochlorine compound, a tertiary amino compound, a member of pyrazines and a monocarboxylic acid amide. It is functionally related to an amiloride.

Biochem/physiol Actions

Selective blocker of Na+/H+ antiport

storage

Store at +4°C

References

[1] B. MASEREEL D. L L Pochet. An overview of inhibitors of Na+/H+ exchanger[J]. European Journal of Medicinal Chemistry, 2003, 38 6: Pages 547-554. DOI: 10.1016/s0223-5234(03)00100-4
[2] S ATTAPHITAYA J E M K Park. Molecular cloning and functional expression of a rat Na+/H+ exchanger (NHE5) highly expressed in brain.[J]. The Journal of Biological Chemistry, 1999, 274 7: 4383-4388. DOI: 10.1074/jbc.274.7.4383
[3] SUNG-MIN HWANG. Intracellular acidification is associated with changes in free cytosolic calcium and inhibition of action potentials in rat trigeminal ganglion.[J]. The Journal of Biological Chemistry, 2011: 1719-1729. DOI: 10.1074/jbc.m109.090951
[4] LIN XUE. Trefoil factor 2 requires Na/H exchanger 2 activity to enhance mouse gastric epithelial repair.[J]. The Journal of Biological Chemistry, 2011: 38375-38382. DOI: 10.1074/jbc.m111.268219

EIPA Preparation Products And Raw materials

Raw materials

Preparation Products

Less

EIPA Suppliers

Canada 1 China 121 Germany 1 India 2 Switzerland 2 United Kingdom 5 United States 13 USA 1 Global 146

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15873
Advantage: 55

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Chengdu Huachun Technology Co., Ltd

Tel: 400-1166-196 15982826727
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2991
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29760
Advantage: 68

Shanghai Zhen Li Biological Technology Co., Ltd

Tel: 021-16621358918; 18516310516
Fax: 13045646768
Email: zhenlipharma888@163.com
Country: China
ProdList: 19035
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 16027
Advantage: 58

SHANGHAI FDC-CHEMICAL CO.,LTD

Tel: 021-61469567 13482353728
Fax: 021-61161605
Email: sales@fdc-chemical.com
Country: China
ProdList: 9717
Advantage: 58

Rhawn Reagent

Tel: 400-400-1332688 18019345275
Fax: 400-133-2688
Email: amy@rhawn.cn
Country: China
ProdList: 14948
Advantage: 58

Jinan Yaoyan Pharmaceutical Co., Ltd.

Tel
Fax: -
Email: jnyaoyan@163.com
Country: China
ProdList: 3069
Advantage: 58

Beijing OKA biological technology co., LTD

Tel: 010-62971590 18548936886
Fax: 010-62340519
Email: 3462612863@qq.com
Country: China
ProdList: 10063
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Nanjing Meihao Pharmaceutical Technology Co., Ltd.

Tel: meitaochem@126.com
Email: meitaochem@126.com
Country: China
ProdList: 19103
Advantage: 58

NewCan Biotech Limited

Tel: +86-0571-86912261 +8613735419629
Email: sales@newcanbio.com
Country: China
ProdList: 9985
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30229
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-29-81148696 +86-17392712697
Email: 1022@dideu.com
Country: China
ProdList: 3995
Advantage: 58

Shanghai Zeye Biotechnology Co., Ltd.

Tel: 021-021-61998551 13122364865
Email: sale1@shzysw.net
Country: China
ProdList: 9778
Advantage: 58

Guangzhou Younan Technology Co., Ltd

Tel: 020-82000279 18988941452
Fax: QQ：3283937693
Email: YN_research@163.com
Country: China
ProdList: 3011
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 18438616290
Email: lanwu@univ-bio.com
Country: China
ProdList: 24731
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

ShangHai ChuanQian Chemcial Technique Centre

Tel: 15869524721
Email: 3525679403@qq.com
Country: China
ProdList: 4989
Advantage: 58

Henan Weitesi Chemical Technology Co. LTD

Tel: 0371-0371-55135753 18003832934
Fax: QQ：2853979818
Email: 2853979818@qq.com
Country: China
ProdList: 9991
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

cjbscvictory

Tel: 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 10503
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

Abmole Bioscience Inc.

Tel: 021-50967598 02150967598
Email: sales@abmole.cn
Country: China
ProdList: 4494
Advantage: 58

Shanghai Universal Biotech Co.,Ltd

Tel: 15921930842 15921930842
Email: yh-wang@univ-bio.com
Country: China
ProdList: 25004
Advantage: 58

Hubei Kele Fine Chemical Co., Ltd

Tel: 027-59101668 19945030958
Fax: 027-59101668
Email: 2881924765@qq.com
Country: China
ProdList: 7938
Advantage: 58

Wuhan Augda Biotechnology Co., Ltd

Tel: 15071299552
Fax: QQ:262933239
Email: 262933239@qq.com
Country: China
ProdList: 7048
Advantage: 58

Shanghai Taopu Industrial Co., LTD

Tel: 159-00573766 18018507602
Email: 394643792@qq.com
Country: China
ProdList: 4328
Advantage: 58

csynbio

Tel: 15051477682
Email: changming.pan@csynbio.com
Country: China
ProdList: 246
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

Kaifeng Mingren Pharmaceutical Co.,LTD

Tel: 0371-65741762
Fax: QQ：2860768577
Email: sales@hasunny.com
Country: China
ProdList: 2380
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Jiangsu Haolong Chemical Co., Ltd

Tel: 0513-89083520 13328092525
Email: 2363930984@qq.com
Country: China
ProdList: 2056
Advantage: 58

Xianning Shen Lan Biomedical Research and Development Co., Ltd.

Tel: 18171815831
Email: 1341138380@qq.com
Country: China
ProdList: 4310
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 18621169109
Email: market03@meryer.com
Country: China
ProdList: 27987
Advantage: 58

Nantong QuanYi Biotechnology Co., Ltd

Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 5929
Advantage: 58

Shandong Mopai Biotechnology Co., Ltd

Tel: 13053322091
Email: admin@mopaikeji.com
Country: China
ProdList: 5830
Advantage: 58

Nanjing Bic Biotechnology Co., Ltd

Tel: 025-58906079 17352406906
Email: sales@bicbiotech.com
Country: China
ProdList: 5996
Advantage: 58

Less

View Lastest Price from EIPA manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: EIPA 1154-25-2
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2024-08-23

1154-25-2, EIPARelated Search:

N-ethyl-pyrrolidone 2-amino-3-chloro-5-methyl-pyrazine 5-(N,N-HEXAMETHYLENE)-AMILORIDE 2-Chloro-6-methylpyrazine 2-Amino-5-chloropyrazine AMILORIDE EIPA (PYRAZIN-2-YL)METHANAMINEHYDROCHLORIDE Pyrazinecarboxaldehyde, 5-(dimethylamino)- (9CI) 3-AMINO-N-METHYLPYRAZINE-2-CARBOXAMIDE 6-CHLORO-3,5-DIAMINO-2-PYRAZINECARBOXAMIDE 6-CHLORO-2-PYRAZINECARBOXAMIDE 2-pyrazinoylguanidine 5-AMINOPYRAZINE-2-CARBOXAMIDE 2-AMINO-3-CHLOROPYRAZINE 3-AMINO-6-CHLOROPYRAZINE-2-CARBALDEHYDE 2,6-Pyrazinediamine(9CI) 5-(N-Ethyl-N-isopropyl)amiloridehydrochloride

AMILORIDE, 5-(N-ETHYL-N-ISOPROPYL)-

Amiloride,5-(N-Ethyl-N-isopropyl)-[5-(N-Ethyl-N-isopropyl)amiloride

5-(N-ETHYL-N-ISOPROPYL)AMILORIDE

3-AMINO-N-(AMINOIMINOMETHYL)-6-CHLORO-5-[ETHYL(2-PROPYL)AMINO]-PYRAZINE-2-CARBOXAMIDE

ethylisopropylamiloride

EIPA

3-Amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-2-pyrazinecarboxamide

L 593754

MH 12-43

Ethylisopropylamiloride (EIPA)

3-Amino-5-(N-ethyl-N-isopropylamino)-6-chloro-N-(aminoiminomethyl)-2-pyrazinecarboxamide

3-Amino-5-[ethyl(isopropyl)amino]-6-chloro-N-(aminoiminomethyl)-2-pyrazinecarboxamide

6-Chloro-3-amino-5-[ethyl(isopropyl)amino]-N-(diaminomethylene)-2-pyrazinecarboxamide

3-amino-6-chloro-N-(diaminomethylene)-5-[ethyl(isopropyl)amino]pyrazinamide

3-amino-6-chloro-N-(diaminomethylidene)-5-[ethyl(propan-2-yl)amino]pyrazine-2-carboxamide

3-azanyl-N-[bis(azanyl)methylidene]-6-chloro-5-[ethyl(propan-2-yl)amino]pyrazine-2-carboxamide

3-aMino-N-carbaMiMidoyl-6-chloro-5-(ethyl(isopropyl)aMino)pyrazine-2-carboxaMide

3-AMino-N-(aMinoiMinoMethyl)-6-chloro-5-[ethyl(1-Methylethyl)aMino]-

2-Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-

EIPA (L593754)

EIPA, 10 mM in DMSO

1154-25-2

C11H8ClN7O

Cell Signaling and Neuroscience

Cell Biology

Amiloride and Derivatives

BioChemical

Monovalent Ion Channels

Ion Channels

Sodium Channel Modulators

Voltage-gated Ion Channels

All Inhibitors

Bases & Related Reagents

Inhibitors

Intermediates & Fine Chemicals

Nucleotides

Pharmaceuticals