ChemicalBook > CAS DataBase List > TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE

TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE

Product Name
TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE
CAS No.
903129-71-5
Chemical Name
TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE
Synonyms
6-Boc-2,4-dichloro-6,7-di...;tert-butyl 2,4-dichloro-5H-pyrrolo[3,4-;6-Boc-2,4-Dichloro-5,7-dihydropyrrolo[3,4-d]pyriMidine;2,4-Dichloro-6,7-dihydro-6-Boc-5H-pyrrolo[3,4-d]pyrimidine;6-Boc-2,4-dichloro-6,7-dihydro-5H-pyrrolo[3,4-d]pyriMidine;tert-butyl 2,4-dichloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimid...;tert-Butyl 2,4-dichloro-5H-pyrrolo[3,4-d]pyriMidine-6(7H)-carbox;ert-Butyl2,4-dichloro-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate;TERT-BUTYL 2,4-DICHLORO-5H,7H-PYRROLO[3,4-D]PYRIMIDINE-6-CARBOXYLATE;TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE
CBNumber
CB1719253
Molecular Formula
C11H13Cl2N3O2
Formula Weight
290.15
MOL File
903129-71-5.mol
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TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE Property

Boiling point:
405.8±45.0 °C(Predicted)
Density 
1.400±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-2.24±0.20(Predicted)
Appearance
White to off-white Solid
InChI
InChI=1S/C11H13Cl2N3O2/c1-11(2,3)18-10(17)16-4-6-7(5-16)14-9(13)15-8(6)12/h4-5H2,1-3H3
InChIKey
WUYSMOCOXBLFKK-UHFFFAOYSA-N
SMILES
C1(Cl)=NC(Cl)=C2CN(C(OC(C)(C)C)=O)CC2=N1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
B695325
Product name
tert-Butyl2,4-Dichloro-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate
Packaging
50mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
069980
Product name
tert-Butyl 2,4-Dichloro-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate
Purity
>95%
Packaging
500mg
Price
$94
Updated
2021/12/16
Matrix Scientific
Product number
069980
Product name
tert-Butyl 2,4-Dichloro-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate
Purity
>95%
Packaging
1g
Price
$145
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-008
Product name
6-Boc-2,4-dichloro-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine
Packaging
1g
Price
$175
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB143128
Product name
tert-Butyl 2,4-dichloro-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate
Packaging
1g
Price
$220
Updated
2021/12/16
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TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE Chemical Properties,Usage,Production

Uses

tert-butyl 2,4-dichloro-5H,6H,7H-pyrrolo[3,4-d]pyrimidine-6-carboxylate is used as an intermediate in organic synthesis.

Synthesis

785775-01-1

24424-99-5

903129-71-5

General procedure for the synthesis of 6-Boc-2,4-dichloro-5,7-dihydropyrrolo[3,4-d]pyrimidines from 2,4-dichloro-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidines and di-tert-butyl dicarbonate: 17.67 g of di-tert-butyl dicarbonate was dissolved in dichloromethane and cooled down to 0 °C, then slowly added dropwise 2,4-dichloro-6,7-dihydro-5H -pyrrolo[3,4-d]pyrimidine (exact mass not provided) followed by the addition of 23.417 mL of triethylamine. The reaction mixture was stirred at room temperature for 3 hours. The progress of the reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was washed three times with water and the organic phase was dried with anhydrous sodium sulfate. Finally, purification by column chromatography using dichloromethane: methanol = 20:1 (v/v) as mobile phase gave 4.12 g of the light yellow solid product 6-Boc-2,4-dichloro-5,7-dihydropyrrolo[3,4-d]pyrimidine in 23% yield.

References

[1] Patent: CN102584828, 2016, B. Location in patent: Paragraph 0114-0116

TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE Suppliers

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View Lastest Price from TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE manufacturers

Career Henan Chemical Co
Product
TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE 903129-71-5
Price
US $3.00/KG
Min. Order
1KG
Purity
99%min
Supply Ability
500kg
Release date
2020-03-06

903129-71-5, TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATERelated Search:

6-broMopyrrolo[1,2-f][1,2,4]triazin-4(3H)-one 4-AMino-6-broMopyrrolo[1,2-f][1,2,4]triazine 6-BROMO-4-CHLOROPYRROLO[1,2-F][1,2,4]TRIAZINE tert-butyl 3-iodo-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate 3-benzyl-7-oxa-3-aza-bicyclo[4.1.0]heptane TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE tert-Butyl 2,4-dichloro-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate tert-butyl 4-amino-5H,6H,7H,8H-pyrido[3,4-d]pyrimidine-7-carboxylate 2-Phenyl-5,7-dihydro-pyrrolo[3,4-d]pyriMidine -6-carboxylic acid tert-butyl ester tert-butyl 2-(trifluoroMethyl)-5,6-dihydropyrido[3,4-d]pyriMidine-7(8H)-carboxylate tert-butyl 4-hydroxy-2-methyl-5H,6H,7H-pyrrolo[3,4-d]pyrimidine-6-carboxylate TERT-BUTYL 4-AMINO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE 2-Methyl-5,8-dihydro-6H-pyrido[3,4-d]pyriMidine-7-carboxylic acid tert-butyl ester 5H-Pyrrolo[3,4-d]pyrimidine, 6,7-dihydro- (9CI) 2,4-Dichloro-5-methylpyrimidine 2,4-Dichloro-6-methylpyrimidine TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE 6,7-DIHYDRO-5H-PYRROLO-[3,4-D]-PYRIMIDINE DIHYDROCHLORIDE

  • TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE
  • 2,4-Dichloro-6,7-dihydro-6-Boc-5H-pyrrolo[3,4-d]pyrimidine
  • tert-butyl 2,4-dichloro-5H-pyrrolo[3,4-
  • 6H-Pyrrolo[3,4-d]pyrimidine-6-carboxylicacid, 2,4-dichloro-5,7-dihydro-, 1,1-dimethylethyl ester
  • tert-Butyl 2,4-dichloro-5H-pyrrolo[3,4-d]pyriMidine-6(7H)-carbox
  • 6-Boc-2,4-dichloro-6,7-dihydro-5H-pyrrolo[3,4-d]pyriMidine
  • 6-Boc-2,4-dichloro-6,7-di...
  • 2,4-Dichloro-5,7-dihydro-pyrrolo[3,4-d]pyriMidine-6-carboxylic acid tert-butyl ester
  • 2,4-Dichloro-5,7-dihydro-6h-pyrrolo[3,4-d]pyriMidine-6-carboxylic acid 1,1-diMethylethyl ester
  • tert-butyl 2,4-dichloro-5H,6H,7H-pyrrolo[3,4-d]pyriMidine-6-carboxylate
  • 6-Boc-2,4-Dichloro-5,7-dihydropyrrolo[3,4-d]pyriMidine
  • tert-Butyl 2,4-dichloro-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylate
  • TERT-BUTYL 2,4-DICHLORO-5H,7H-PYRROLO[3,4-D]PYRIMIDINE-6-CARBOXYLATE
  • ert-Butyl2,4-dichloro-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate
  • tert-butyl 2,4-dichloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimid...
  • 903129-71-5
  • Heterocycle-Pyrimidine series
  • CHIRAL CHEMICALS