TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE

Product Name: TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE
CAS No.: 903129-71-5
Chemical Name: TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE
Synonyms: 6-Boc-2,4-dichloro-6,7-di...;tert-butyl 2,4-dichloro-5H-pyrrolo[3,4-;6-Boc-2,4-Dichloro-5,7-dihydropyrrolo[3,4-d]pyriMidine;2,4-Dichloro-6,7-dihydro-6-Boc-5H-pyrrolo[3,4-d]pyrimidine;6-Boc-2,4-dichloro-6,7-dihydro-5H-pyrrolo[3,4-d]pyriMidine;tert-butyl 2,4-dichloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimid...;tert-Butyl 2,4-dichloro-5H-pyrrolo[3,4-d]pyriMidine-6(7H)-carbox;ert-Butyl2,4-dichloro-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate;TERT-BUTYL 2,4-DICHLORO-5H,7H-PYRROLO[3,4-D]PYRIMIDINE-6-CARBOXYLATE;TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE
CBNumber: CB1719253
Molecular Formula: C11H13Cl2N3O2
Formula Weight: 290.15
MOL File: 903129-71-5.mol

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TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE Property

Boiling point:: 405.8±45.0 °C(Predicted)
Density: 1.400±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -2.24±0.20(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C11H13Cl2N3O2/c1-11(2,3)18-10(17)16-4-6-7(5-16)14-9(13)15-8(6)12/h4-5H2,1-3H3
InChIKey: WUYSMOCOXBLFKK-UHFFFAOYSA-N
SMILES: C1(Cl)=NC(Cl)=C2CN(C(OC(C)(C)C)=O)CC2=N1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B695325
Product name: tert-Butyl2,4-Dichloro-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 069980
Product name: tert-Butyl 2,4-Dichloro-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate
Purity: >95%
Packaging: 500mg
Price: $94
Updated: 2021/12/16

Matrix Scientific

Product number: 069980
Product name: tert-Butyl 2,4-Dichloro-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate
Purity: >95%
Packaging: 1g
Price: $145
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-008
Product name: 6-Boc-2,4-dichloro-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine
Packaging: 1g
Price: $175
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB143128
Product name: tert-Butyl 2,4-dichloro-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate
Packaging: 1g
Price: $220
Updated: 2021/12/16

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TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE Chemical Properties,Usage,Production

Uses

tert-butyl 2,4-dichloro-5H,6H,7H-pyrrolo[3,4-d]pyrimidine-6-carboxylate is used as an intermediate in organic synthesis.

Synthesis

785775-01-1

24424-99-5

903129-71-5

General procedure for the synthesis of 6-Boc-2,4-dichloro-5,7-dihydropyrrolo[3,4-d]pyrimidines from 2,4-dichloro-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidines and di-tert-butyl dicarbonate: 17.67 g of di-tert-butyl dicarbonate was dissolved in dichloromethane and cooled down to 0 °C, then slowly added dropwise 2,4-dichloro-6,7-dihydro-5H -pyrrolo[3,4-d]pyrimidine (exact mass not provided) followed by the addition of 23.417 mL of triethylamine. The reaction mixture was stirred at room temperature for 3 hours. The progress of the reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was washed three times with water and the organic phase was dried with anhydrous sodium sulfate. Finally, purification by column chromatography using dichloromethane: methanol = 20:1 (v/v) as mobile phase gave 4.12 g of the light yellow solid product 6-Boc-2,4-dichloro-5,7-dihydropyrrolo[3,4-d]pyrimidine in 23% yield.

References

[1] Patent: CN102584828, 2016, B. Location in patent: Paragraph 0114-0116

TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE Suppliers

China 148 Germany 1 India 1 United Kingdom 1 United States 13 Global 164

A.J Chemicals

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View Lastest Price from TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE manufacturers

Career Henan Chemical Co

Product: TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE 903129-71-5
Price: US $3.00/KG
Min. Order: 1KG
Purity: 99%min
Supply Ability: 500kg
Release date: 2020-03-06

903129-71-5, TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATERelated Search:

6-broMopyrrolo[1,2-f][1,2,4]triazin-4(3H)-one 4-AMino-6-broMopyrrolo[1,2-f][1,2,4]triazine 6-BROMO-4-CHLOROPYRROLO[1,2-F][1,2,4]TRIAZINE tert-butyl 3-iodo-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate 3-benzyl-7-oxa-3-aza-bicyclo[4.1.0]heptane TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE tert-Butyl 2,4-dichloro-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate tert-butyl 4-amino-5H,6H,7H,8H-pyrido[3,4-d]pyrimidine-7-carboxylate 2-Phenyl-5,7-dihydro-pyrrolo[3,4-d]pyriMidine -6-carboxylic acid tert-butyl ester tert-butyl 2-(trifluoroMethyl)-5,6-dihydropyrido[3,4-d]pyriMidine-7(8H)-carboxylate tert-butyl 4-hydroxy-2-methyl-5H,6H,7H-pyrrolo[3,4-d]pyrimidine-6-carboxylate TERT-BUTYL 4-AMINO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE 2-Methyl-5,8-dihydro-6H-pyrido[3,4-d]pyriMidine-7-carboxylic acid tert-butyl ester 5H-Pyrrolo[3,4-d]pyrimidine, 6,7-dihydro- (9CI) 2,4-Dichloro-5-methylpyrimidine 2,4-Dichloro-6-methylpyrimidine TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE 6,7-DIHYDRO-5H-PYRROLO-[3,4-D]-PYRIMIDINE DIHYDROCHLORIDE

TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE

2,4-Dichloro-6,7-dihydro-6-Boc-5H-pyrrolo[3,4-d]pyrimidine

tert-butyl 2,4-dichloro-5H-pyrrolo[3,4-

6H-Pyrrolo[3,4-d]pyrimidine-6-carboxylicacid, 2,4-dichloro-5,7-dihydro-, 1,1-dimethylethyl ester

tert-Butyl 2,4-dichloro-5H-pyrrolo[3,4-d]pyriMidine-6(7H)-carbox

6-Boc-2,4-dichloro-6,7-dihydro-5H-pyrrolo[3,4-d]pyriMidine

6-Boc-2,4-dichloro-6,7-di...

2,4-Dichloro-5,7-dihydro-pyrrolo[3,4-d]pyriMidine-6-carboxylic acid tert-butyl ester

2,4-Dichloro-5,7-dihydro-6h-pyrrolo[3,4-d]pyriMidine-6-carboxylic acid 1,1-diMethylethyl ester

tert-butyl 2,4-dichloro-5H,6H,7H-pyrrolo[3,4-d]pyriMidine-6-carboxylate

6-Boc-2,4-Dichloro-5,7-dihydropyrrolo[3,4-d]pyriMidine

tert-Butyl 2,4-dichloro-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylate

TERT-BUTYL 2,4-DICHLORO-5H,7H-PYRROLO[3,4-D]PYRIMIDINE-6-CARBOXYLATE

ert-Butyl2,4-dichloro-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate

tert-butyl 2,4-dichloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimid...

903129-71-5

Heterocycle-Pyrimidine series

CHIRAL CHEMICALS