Ethyl N-(diphenylmethylene)glycinate

Product Name: Ethyl N-(diphenylmethylene)glycinate
CAS No.: 69555-14-2
Chemical Name: Ethyl N-(diphenylmethylene)glycinate
Synonyms: ethyl 2-[(diphenylMethylidene)aMino]acetate;ETHYL (DIPHENYLMETHYLENAMINO)ACETATE;N-(DIPHENYLMETHYLENE)GLYCINE ETHYL ESTER;(N,N-DIPHENYLMETHYLENE)GLYCINE ETHYL ESTER;NSC 263808;DPM-Gly-Oet;N-(DiphenyL;AURORA KA-6707;Ethyl N-(diphenylmet;N-Benzhydrylideneglycine ethyl
CBNumber: CB1720354
Molecular Formula: C17H17NO2
Formula Weight: 267.32
MOL File: 69555-14-2.mol

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Ethyl N-(diphenylmethylene)glycinate Property

Melting point:: 51-53 °C(lit.)
Boiling point:: 195°C/2mmHg(lit.)
Density: 1.0690 (rough estimate)
refractive index: 1.5400 (estimate)
Flash point:: >110°C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 2.22±0.50(Predicted)
form: Crystalline Powder or Crystals
color: White to light yellow
Sensitive: Moisture Sensitive
λmax: 247nm(Hexane)(lit.)
BRN: 1979922
Stability:: Moisture Sensitive
InChIKey: QUGJYNGNUBHTNS-UHFFFAOYSA-N
LogP: 1.35-3.18 at 25℃ and pH0-14
Dissociation constant: 2.3 at 25℃
CAS DataBase Reference: 69555-14-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25-36/37-26
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
F: 10-21
HS Code: 29224999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 222542
Product name: N-(Diphenylmethylene)glycine ethyl ester
Purity: 98%
Packaging: 5g
Price: $130.15
Updated: 2025/07/31

Sigma-Aldrich

Product number: 222542
Product name: N-(Diphenylmethylene)glycine ethyl ester
Purity: 98%
Packaging: 25g
Price: $372.9
Updated: 2025/07/31

TCI Chemical

Product number: D3833
Product name: N-(Diphenylmethylene)glycine Ethyl Ester
Purity: >97.0%(T)
Packaging: 5g
Price: $40
Updated: 2025/07/31

TCI Chemical

Product number: D3833
Product name: N-(Diphenylmethylene)glycine Ethyl Ester
Purity: >97.0%(T)
Packaging: 25g
Price: $163
Updated: 2025/07/31

TRC

Product number: D491635
Product name: N-(Diphenylmethylene)glycine Ethyl Ester
Packaging: 1g
Price: $65
Updated: 2021/12/16

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Ethyl N-(diphenylmethylene)glycinate Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystalline powder or

Uses

N-(Diphenylmethylene)glycine Ethyl Ester is used as a reagent in the synthesis of pyrazolopyrrolyl tetrahydropyran DPP-4 inhibitors.

Application

Ethyl N-(diphenylmethylene)glycinate features a diphenylmethylene group that enhances its reactivity and stability, making it particularly useful in organic synthesis and pharmaceutical development.

Reactions

Ethyl N-(diphenylmethylene)glycinate undergoes monoalkylations, dialkylations and Michael additions to ethylenic and acetylenic acceptors under appropriate solid-liquid phase transfer catalysis conditions. Further transformations of the α-disubstituted ketimines lead to α-alkylated aspartic and glutamic acid derivatives.

Synthesis

Ethyl N-(diphenylmethylene)glycinate is prepared by transimination of Benzophenone Imine with alkyl glycinate hydrochloride (room temperature/CH2Cl2).

References

[1] Patent: EP1422220, 2004, A1. Location in patent: Page 5
[2] Patent: CN104557684, 2017, B. Location in patent: Paragraph 0021-0026; 0027; 0028; 0029; 0030-0033
[3] Tetrahedron Letters, 2005, vol. 46, # 16, p. 2795 - 2797
[4] Patent: US2010/173777, 2010, A1. Location in patent: Page/Page column 23
[5] Patent: WO2016/27285, 2016, A2. Location in patent: Page/Page column 50; 51

Ethyl N-(diphenylmethylene)glycinate Preparation Products And Raw materials

Raw materials

Glycine ethyl ester hydrochloride Bromobenzene Diethyl ether Dichloromethane Benzonitrile Magnesium

Preparation Products

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View Lastest Price from Ethyl N-(diphenylmethylene)glycinate manufacturers

Shandong Vital Biotechnology Co., Ltd.

Product: Ethyl N-(diphenylmethylene)glycinate 69555-14-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100tons
Release date: 2025-11-19

Hebei Chuanghai Biotechnology Co., Ltd

Product: Ethyl N-(diphenylmethylene)glycinate 69555-14-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-29

Henan Aochuang Chemical Co.,Ltd.

Product: Ethyl N-(diphenylmethylene)glycinate 69555-14-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-23

69555-14-2, Ethyl N-(diphenylmethylene)glycinateRelated Search:

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69555-14-2

C6H52CNCH2CO2C2H5

Amino Acid Derivatives

Peptide Synthesis

Specialty Synthesis

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Intermediates

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Amino Acids