4-Amino-L-phenylalanine

Product Name: 4-Amino-L-phenylalanine
CAS No.: 943-80-6
Chemical Name: 4-Amino-L-phenylalanine
Synonyms: 4-Amino-L;4-Amino-Phe;L-4-AMINOPHE;4-Amino-L-Phe;L-4-NH2-Phe-OH;4-Amino-Phe-OH;H-PHE(4-NH2)-OH;H-PHE(4'-NH2)-OH;H-L-Phe(4-NH2)-OH;Aminophenyalanine
CBNumber: CB1722156
Molecular Formula: C9H12N2O2
Formula Weight: 180.2
MOL File: 943-80-6.mol

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4-Amino-L-phenylalanine Property

Melting point:: 265 °C (decomp)
Boiling point:: 383.5±32.0 °C(Predicted)
Density: 1.289±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: Methanol (Slightly, Sonicated), Water (Slightly, Sonicated)
form: Solid
pka: 2.14±0.10(Predicted)
color: Pale Beige to Beige
Water Solubility: Soluble in water.
Sensitive: Air Sensitive
CAS DataBase Reference: 943-80-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2922498590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A622376
Product name: p-Amino-L-phenylalanine
Packaging: 2.5g
Price: $145
Updated: 2021/12/16

Usbiological

Product number: 232813
Product name: 4-Amino-L-phenylalanine 99+%
Packaging: 1g
Price: $170
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0000765
Product name: 4-AMINO-L-PHENYL ALANINE
Purity: 95.00%
Packaging: 1G
Price: $159.71
Updated: 2021/12/16

Iris Biotech GmbH

Product number: HAA7050
Product name: H-L-Phe(4-NH2)-OH*hydrate
Packaging: 5G
Price: $162
Updated: 2021/12/16

chempep

Product number: 181603
Product name: H-Phe(4-NH2)-OH
Packaging: 25g
Price: $330
Updated: 2021/12/16

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4-Amino-L-phenylalanine Chemical Properties,Usage,Production

Chemical Properties

Off-white crystalline powder

Uses

It finds its application in the purification of peptide synthetases involved in pristinamycin I biosynthesis.

Definition

ChEBI: 4-amino-L-phenylalanine is the L-enantiomer of 4-aminophenylalanine. It is an enantiomer of a 4-amino-D-phenylalanine. It is a tautomer of a 4-amino-L-phenylalanine zwitterion.

Synthesis

949-99-5

943-80-6

A mixed solution of concentrated HNO3 (60%) and concentrated H2SO4 (1.4:1.1 v/v) was prepared and cooled to 10°C. A portion of the mixed solution (3.5 mL) was slowly added dropwise to a solution of L-phenylalanine (4.139 g, 25.1 mmol) in H2SO4 (98%, 12.5 mL) with stirring. The reaction mixture was kept stirred at 10 °C for 2.5 hours. Upon completion of the reaction, the pH of the reaction solution was adjusted with NH4OH to 5. The resulting light yellow precipitate was collected by filtration, washed sequentially with a small amount of water and CH3CN, and dried to give 4-nitro-L-phenylalanine as a yellow powder (4.748 g, 90% yield). 4-Nitro-L-phenylalanine (2.006 g, 9.54 mmol) was suspended in water (35 mL), 0.2 g of 5% palladium-barium sulfate catalyst was added, and the hydrogenation reaction was carried out for 3 h at room temperature. The reaction solution was filtered through a diatomaceous earth pad and the filtrate was concentrated to give a light brown residue. The residue was washed with CH3CN to give a light brown solid (1.460 g, 85% yield) which was used directly in the next step of the reaction. 4-Amino-L-phenylalanine derivative (0.060 g, 0.33 mmol) was dissolved in 6N HCl (4 mL) and aqueous sodium nitrate solution (0.030 g/0.5 mL) was slowly added at 0 °C. The reaction mixture was stirred at the same temperature for 40 min and then diluted with 6N HCl (0.25 mL). Subsequently, aqueous sodium azide solution (0.033 g/0.75 mL) was added at 0 °C. The reaction mixture was stirred at 0 °C for 5 min and then warmed up to room temperature to continue the reaction for 1 h. The reaction mixture was then concentrated and the reaction was carried out at room temperature. Upon completion of the reaction, the reaction solution was concentrated and the residue was reprecipitated by CH3CN to give a pure colorless amorphous solid (0.0435 g, 64% yield). The analytical and spectroscopic data of the product were in agreement with literature reports [10].

IC 50

Human Endogenous Metabolite

References

[1] Letters in Drug Design and Discovery, 2015, vol. 12, # 6, p. 466 - 470
[2] Molecules, 2013, vol. 18, # 7, p. 8393 - 8401
[3] Helvetica Chimica Acta, 1957, vol. 40, p. 80,83
[4] Chemistry Letters, 1998, # 7, p. 704 - 706
[5] Chemistry Letters, 1998, # 6, p. 537 - 538

4-Amino-L-phenylalanine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Amino-L-phenylalanine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Amino-L-phenylalanine 943-80-6
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2024-08-28

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-Amino-L-phenylalanine 943-80-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Career Henan Chemical Co

Product: 4-Amino-L-phenylalanine 943-80-6
Price: US $8.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10MT
Release date: 2018-12-21

943-80-6, 4-Amino-L-phenylalanineRelated Search:

Phenprobamate ALTRENOGEST N-(tert-Butoxycarbonyl)-L-phenylalanine Glycine Betaine D-Phenylalanine L-Phenylalanine 4-Methylphenyl-L-alanine L-4-AMINOMETHYLPHE L-4-CARBAMOYLPHE L-4-BENZOYLPHENYLALANINE L-4-Iodophenylalanine L-4-Chlorophenylalanine L-PHE(4-COCH3) L-4-Fluorophenylalanine O-METHYL-L-TYROSINE 4-Nitro-3-phenyl-L-alanine 4-Bromo-L-phenylalanine

4-Amino-Phe

L-4-NH2-Phe-OH

4-AMINO-L-PHENYLALANINE 99%

L-2-Amino-3-(4-amino-phenyl)-propionic acid

H-L-Phe(4-NH2)-OH

4-Amino-L-Phe

Aminophenyalanine

p-Aminophenylalanine

(2S)-2-amino-3-(4-aminophenyl)propionic acid

(2S)-2-azanyl-3-(4-azanylphenyl)propanoic acid

4-Amino-L-phenylalan

L-4-NH2-Phe-OH 4-AMino-L-Phenylalanine

para-Aminophenylalanine

Phenylalanine, 4-amino-

L-4-AMINOPHE

L-4-AMINOPHENYLALANINE

L-4-AMINOPHENYLALANINE DIHYDROCHLORIDE

H-PHE(P-NH2)-OH 2HCL

H-PHE(4-NH2)-OH

H-PHE(4-NH2)-OH 2HCL

H-P-AMINO-L-PHE-OH

L-P-AMINOPHENYLALANINE 2HCL

4-AMINO-PHENYLALANINE

4-AMINO-L-PHENYLALANINE

(S)-2-AMINO-3-(4-AMINOPHENYL)PROPANOIC ACID

P-AMINO-L-PHENYLALANINE

H-PHE(4'-NH2)-OH

4-Amino-L-phenylalanine≥ 99% (HPLC)

π-Amino-L-phenylalanine

4-Amino-Phe-OH

(2R)-2-amino-3-(4-aminophenyl)propanoic acid

4-amino-pyenylalanine

4-Amino-L

L-Phenylalanine, 4-amino-

4-Amino-L-phenylalanine,95%

4-Amino-L-phenylalanine USP/EP/BP

Melphalan Impurity 28

943-80-6

C9H12N2O2

Carboxylic acid

Amines

Phenylalanine [Phe, F]

a-amino

Phenylalanine analogs and other aromatic alpha amino acids

Unusual Amino Acids

Amino Acids 13C, 2H, 15N

Chiral Compound

Amino Acids