Triflupromazine hydrochloride

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Triflupromazine hydrochloride

Product Name: Triflupromazine hydrochloride
CAS No.: 1098-60-8
Chemical Name: Triflupromazine hydrochloride
Synonyms: Neoprin;Flumazin;Fluorofen;triflupromazineHCl;LABOTEST-BB LT00772332;TRIFLUPROMAZINE HCL IP/USP;Fluopromazine hydrochloride;TRIFLUPROMAZINE HYDROCHLORIDE;trifluopromazinehydrochloride;Triupromazine Hydrochloride (200 mg)
CBNumber: CB1723214
Molecular Formula: C18H20ClF3N2S
Formula Weight: 388.88
MOL File: 1098-60-8.mol

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Triflupromazine hydrochloride Property

Melting point:: 174.0 to 179.0 °C
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
Water Solubility: Soluble in water
solubility: DMF: 5mg/mL; DMSO: 3mg/mL; Ethanol: 5mg/mL; Ethanol:PBS (pH 7.2) (1:10): 0.09mg/mL
color: White to Light yellow
λmax: 305nm(H2O)(lit.)
Merck: 14,9685
BRN: 3801519
Stability:: Hygroscopic
CAS DataBase Reference: 1098-60-8

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22
Safety Statements: 36
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: SO8925000
HazardClass: 6.1
PackingGroup: III
HS Code: 2934302300

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1686003
Product name: Triflupromazine hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $267
Updated: 2024/03/01

Sigma-Aldrich

Product number: 46976
Product name: Triflupromazine hydrochloride
Purity: VETRANAL?, analytical standard
Packaging: 50mg
Price: $190
Updated: 2022/05/15

TCI Chemical

Product number: T3389
Product name: Triflupromazine Hydrochloride
Purity: >98.0%(HPLC)(N)
Packaging: 5g
Price: $122
Updated: 2024/03/01

TCI Chemical

Product number: T3389
Product name: Triflupromazine Hydrochloride
Purity: >98.0%(HPLC)(N)
Packaging: 25g
Price: $365
Updated: 2024/03/01

Cayman Chemical

Product number: 27610
Product name: Triflupromazine (hydrochloride)
Packaging: 1g
Price: $32
Updated: 2024/03/01

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Triflupromazine hydrochloride Chemical Properties,Usage,Production

Description

Triflupromazine is a phenothiazine with diverse biological activities. It binds to muscarinic receptors in isolated rat corpus striatum (IC₅₀ = 100 μM in a radioligand binding assay). Triflupromazine inhibits serotonin (5-HT) uptake by isolated rat brainstem synaptosomes (IC₅₀ = 0.8 μM). It inhibits T. cruzi infection in mouse peritoneal macrophages when used at a concentration of 12.5 μM. Triflupromazine is active against S. aureus, shigellae, and vibrios (MICs = 2-100 μg/ml) in vitro and is protective against S. typhimurium infection in mice when administered at a dose of 30 μg per animal. Formulations containing triflupromazine were previously used as antipsychotics.

Originator

Vesprin,Squibb,US,1957

Uses

analgesic, antiinflammatory, antipyretic, COX-II inhibitor

Manufacturing Process

Approximately 3.8 grams of sodamide is freshly prepared from 2.25 grams of sodium, 90 grams of liquid ammonia and a catalytic trace of ferric nitrate. The ammonia is allowed to evaporate. A solution of 19.1 grams of 2-trifluoromethylphenothiazine (prepared by the Bernthsen thionation of 3- trifluoromethyldiphenylamine) in 160 ml of dry benzene is added to the reaction flask followed by 18 grams of 3-chloro-1-dimethylaminopropane. The reaction mixture is heated at reflux for 20 hours. After washing the cooled mixture with 130 ml of water, the organic layer is extracted with several portions of dilute hydrochloric acid. The acid extracts are combined and neutralized with ammonium hydroxide solution. The oily free base is extracted into benzene and purified by distillation to give 19.6 grams of 10-(3'- dimethylaminopropyl)-2-trifluoromethylphenothiazine, boiling point 177° to 181°C at 1 mm. The free base (7 grams) is converted to the hydrochloride salt by reacting an alcoholic solution of the base with hydrogen chloride gas.
Evaporation of the volatiles in vacuo leaves an amorphous solid which is recrystallized from ethanol/ether to pink crystals, MP 173° to 174°C, the hydrochloride salt of the free base prepared above.

brand name

Vesprin (Bristol-Myers Squibb).

Therapeutic Function

Tranquilizer

General Description

Triflupromazinehydrochloride, 10-[3-(dimethylamino)propyl]-2-(trifluoromethyl)phenothiazine monohydrochloride (Vesprin), has agreater milligram potency as an antipsychotic, higher EPS,but lower sedative and hypotensive effects than chlorpromazine.The 2-CF₃ versus the 2-Cl is associated with thesechanges. Overall, the drug has uses analogous to those ofchlorpromazine.

Triflupromazine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Triflupromazine hydrochloride manufacturers

Dideu Industries Group Limited

Product: TRIFLUPROMAZINE HYDROCHLORIDE 1098-60-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-23

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1098-60-8

C18H19F3N2SHCl

C18H20ClF3N2S

C18H19F3N2SClH

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