TRIFLUPROMAZINE HYDROCHLORIDE
- Product Name
- TRIFLUPROMAZINE HYDROCHLORIDE
- CAS No.
- 1098-60-8
- Chemical Name
- TRIFLUPROMAZINE HYDROCHLORIDE
- Synonyms
- Neoprin;Flumazin;Fluorofen;triflupromazineHCl;LABOTEST-BB LT00772332;TRIFLUPROMAZINE HCL IP/USP;Fluopromazine hydrochloride;TRIFLUPROMAZINE HYDROCHLORIDE;trifluopromazinehydrochloride;Triupromazine Hydrochloride (200 mg)
- CBNumber
- CB1723214
- Molecular Formula
- C18H20ClF3N2S
- Formula Weight
- 388.88
- MOL File
- 1098-60-8.mol
TRIFLUPROMAZINE HYDROCHLORIDE Property
- Melting point:
- 174.0 to 179.0 °C
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- Water Solubility
- Soluble in water
- solubility
- DMF: 5mg/mL; DMSO: 3mg/mL; Ethanol: 5mg/mL; Ethanol:PBS (pH 7.2) (1:10): 0.09mg/mL
- color
- White to Light yellow
- λmax
- 305nm(H2O)(lit.)
- Merck
- 14,9685
- BRN
- 3801519
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 1098-60-8
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 1686003
- Product name
- Triflupromazine hydrochloride
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $267
- Updated
- 2024/03/01
- Product number
- 46976
- Product name
- Triflupromazine hydrochloride
- Purity
- VETRANAL?, analytical standard
- Packaging
- 50mg
- Price
- $190
- Updated
- 2022/05/15
- Product number
- T3389
- Product name
- Triflupromazine Hydrochloride
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 5g
- Price
- $122
- Updated
- 2024/03/01
- Product number
- T3389
- Product name
- Triflupromazine Hydrochloride
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 25g
- Price
- $365
- Updated
- 2024/03/01
- Product number
- 27610
- Product name
- Triflupromazine (hydrochloride)
- Packaging
- 1g
- Price
- $32
- Updated
- 2024/03/01
TRIFLUPROMAZINE HYDROCHLORIDE Chemical Properties,Usage,Production
Description
Triflupromazine is a phenothiazine with diverse biological activities. It binds to muscarinic receptors in isolated rat corpus striatum (IC50 = 100 μM in a radioligand binding assay). Triflupromazine inhibits serotonin (5-HT) uptake by isolated rat brainstem synaptosomes (IC50 = 0.8 μM). It inhibits T. cruzi infection in mouse peritoneal macrophages when used at a concentration of 12.5 μM. Triflupromazine is active against S. aureus, shigellae, and vibrios (MICs = 2-100 μg/ml) in vitro and is protective against S. typhimurium infection in mice when administered at a dose of 30 μg per animal. Formulations containing triflupromazine were previously used as antipsychotics.
Originator
Vesprin,Squibb,US,1957
Uses
analgesic, antiinflammatory, antipyretic, COX-II inhibitor
Manufacturing Process
Approximately 3.8 grams of sodamide is freshly prepared from 2.25 grams of
sodium, 90 grams of liquid ammonia and a catalytic trace of ferric nitrate. The
ammonia is allowed to evaporate. A solution of 19.1 grams of 2-trifluoromethylphenothiazine (prepared by the Bernthsen thionation of 3-
trifluoromethyldiphenylamine) in 160 ml of dry benzene is added to the
reaction flask followed by 18 grams of 3-chloro-1-dimethylaminopropane. The
reaction mixture is heated at reflux for 20 hours. After washing the cooled
mixture with 130 ml of water, the organic layer is extracted with several
portions of dilute hydrochloric acid. The acid extracts are combined and
neutralized with ammonium hydroxide solution. The oily free base is extracted
into benzene and purified by distillation to give 19.6 grams of 10-(3'-
dimethylaminopropyl)-2-trifluoromethylphenothiazine, boiling point 177° to
181°C at 1 mm. The free base (7 grams) is converted to the hydrochloride
salt by reacting an alcoholic solution of the base with hydrogen chloride gas.
Evaporation of the volatiles in vacuo leaves an amorphous solid which is
recrystallized from ethanol/ether to pink crystals, MP 173° to 174°C, the
hydrochloride salt of the free base prepared above.
brand name
Vesprin (Bristol-Myers Squibb).
Therapeutic Function
Tranquilizer
General Description
Triflupromazinehydrochloride, 10-[3-(dimethylamino)propyl]-2-(trifluoromethyl)phenothiazine monohydrochloride (Vesprin), has agreater milligram potency as an antipsychotic, higher EPS,but lower sedative and hypotensive effects than chlorpromazine.The 2-CF3 versus the 2-Cl is associated with thesechanges. Overall, the drug has uses analogous to those ofchlorpromazine.
TRIFLUPROMAZINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
TRIFLUPROMAZINE HYDROCHLORIDE Suppliers
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View Lastest Price from TRIFLUPROMAZINE HYDROCHLORIDE manufacturers
- Product
- TRIFLUPROMAZINE HYDROCHLORIDE 1098-60-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-07-23