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TRIFLUPROMAZINE HYDROCHLORIDE

Product Name
TRIFLUPROMAZINE HYDROCHLORIDE
CAS No.
1098-60-8
Chemical Name
TRIFLUPROMAZINE HYDROCHLORIDE
Synonyms
Neoprin;Flumazin;Fluorofen;triflupromazineHCl;LABOTEST-BB LT00772332;TRIFLUPROMAZINE HCL IP/USP;Fluopromazine hydrochloride;TRIFLUPROMAZINE HYDROCHLORIDE;trifluopromazinehydrochloride;Triupromazine Hydrochloride (200 mg)
CBNumber
CB1723214
Molecular Formula
C18H20ClF3N2S
Formula Weight
388.88
MOL File
1098-60-8.mol
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TRIFLUPROMAZINE HYDROCHLORIDE Property

Melting point:
174.0 to 179.0 °C
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
Water Solubility 
Soluble in water
solubility 
DMF: 5mg/mL; DMSO: 3mg/mL; Ethanol: 5mg/mL; Ethanol:PBS (pH 7.2) (1:10): 0.09mg/mL
color 
White to Light yellow
λmax
305nm(H2O)(lit.)
Merck 
14,9685
BRN 
3801519
Stability:
Hygroscopic
CAS DataBase Reference
1098-60-8
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
36
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
SO8925000
HazardClass 
6.1
PackingGroup 
III
HS Code 
2934302300
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1686003
Product name
Triflupromazine hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$267
Updated
2024/03/01
Sigma-Aldrich
Product number
46976
Product name
Triflupromazine hydrochloride
Purity
VETRANAL?, analytical standard
Packaging
50mg
Price
$190
Updated
2022/05/15
TCI Chemical
Product number
T3389
Product name
Triflupromazine Hydrochloride
Purity
>98.0%(HPLC)(N)
Packaging
5g
Price
$122
Updated
2024/03/01
TCI Chemical
Product number
T3389
Product name
Triflupromazine Hydrochloride
Purity
>98.0%(HPLC)(N)
Packaging
25g
Price
$365
Updated
2024/03/01
Cayman Chemical
Product number
27610
Product name
Triflupromazine (hydrochloride)
Packaging
1g
Price
$32
Updated
2024/03/01
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TRIFLUPROMAZINE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Triflupromazine is a phenothiazine with diverse biological activities. It binds to muscarinic receptors in isolated rat corpus striatum (IC50 = 100 μM in a radioligand binding assay). Triflupromazine inhibits serotonin (5-HT) uptake by isolated rat brainstem synaptosomes (IC50 = 0.8 μM). It inhibits T. cruzi infection in mouse peritoneal macrophages when used at a concentration of 12.5 μM. Triflupromazine is active against S. aureus, shigellae, and vibrios (MICs = 2-100 μg/ml) in vitro and is protective against S. typhimurium infection in mice when administered at a dose of 30 μg per animal. Formulations containing triflupromazine were previously used as antipsychotics.

Originator

Vesprin,Squibb,US,1957

Uses

analgesic, antiinflammatory, antipyretic, COX-II inhibitor

Manufacturing Process

Approximately 3.8 grams of sodamide is freshly prepared from 2.25 grams of sodium, 90 grams of liquid ammonia and a catalytic trace of ferric nitrate. The ammonia is allowed to evaporate. A solution of 19.1 grams of 2-trifluoromethylphenothiazine (prepared by the Bernthsen thionation of 3- trifluoromethyldiphenylamine) in 160 ml of dry benzene is added to the reaction flask followed by 18 grams of 3-chloro-1-dimethylaminopropane. The reaction mixture is heated at reflux for 20 hours. After washing the cooled mixture with 130 ml of water, the organic layer is extracted with several portions of dilute hydrochloric acid. The acid extracts are combined and neutralized with ammonium hydroxide solution. The oily free base is extracted into benzene and purified by distillation to give 19.6 grams of 10-(3'- dimethylaminopropyl)-2-trifluoromethylphenothiazine, boiling point 177° to 181°C at 1 mm. The free base (7 grams) is converted to the hydrochloride salt by reacting an alcoholic solution of the base with hydrogen chloride gas.
Evaporation of the volatiles in vacuo leaves an amorphous solid which is recrystallized from ethanol/ether to pink crystals, MP 173° to 174°C, the hydrochloride salt of the free base prepared above.

brand name

Vesprin (Bristol-Myers Squibb).

Therapeutic Function

Tranquilizer

General Description

Triflupromazinehydrochloride, 10-[3-(dimethylamino)propyl]-2-(trifluoromethyl)phenothiazine monohydrochloride (Vesprin), has agreater milligram potency as an antipsychotic, higher EPS,but lower sedative and hypotensive effects than chlorpromazine.The 2-CF3 versus the 2-Cl is associated with thesechanges. Overall, the drug has uses analogous to those ofchlorpromazine.

TRIFLUPROMAZINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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TRIFLUPROMAZINE HYDROCHLORIDE Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
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69
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
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81
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
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79
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
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60
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
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55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4674
Advantage
55
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View Lastest Price from TRIFLUPROMAZINE HYDROCHLORIDE manufacturers

Dideu Industries Group Limited
Product
TRIFLUPROMAZINE HYDROCHLORIDE 1098-60-8
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-23

1098-60-8, TRIFLUPROMAZINE HYDROCHLORIDERelated Search:


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