2-Chloro-4-methylsulphonylbenzoic acid

Product Name: 2-Chloro-4-methylsulphonylbenzoic acid
CAS No.: 53250-83-2
Chemical Name: 2-Chloro-4-methylsulphonylbenzoic acid
Synonyms: 2-Chloro-4-Met;RARECHEM AL BE 1445;TIMTEC-BB SBB003254;2-Chloro-4-methylsul;Bupropion Impurity 46;2-chloro-4-sulfonyl acid;2-Chloro-4-mesylbenzoic acid;2-chloro-4-methylsulfonylbenzoate;2-Chloro-4-methylsulfonylbenzoic a;2-Chlor-4-(methylsulfonyl)benzoesure
CBNumber: CB1724059
Molecular Formula: C8H7ClO4S
Formula Weight: 234.66
MOL File: 53250-83-2.mol

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2-Chloro-4-methylsulphonylbenzoic acid Property

Melting point:: 192-193 °C
Boiling point:: 454.8±45.0 °C(Predicted)
Density: 1.4452 (estimate)
storage temp.: Sealed in dry,Room Temperature
pka: 2.09±0.25(Predicted)
form: Powder
color: White to light yellow or light pink
InChI: InChI=1S/C8H7ClO4S/c1-14(12,13)5-2-3-6(8(10)11)7(9)4-5/h2-4H,1H3,(H,10,11)
InChIKey: CTTWSFIIFMWHLQ-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC=C(S(C)(=O)=O)C=C1Cl
CAS DataBase Reference: 53250-83-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 41-36/37/38
Safety Statements: 36/37/39-26-22-39
Hazard Note: Irritant
HS Code: 29309090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C2726
Product name: 2-Chloro-4-(methylsulfonyl)benzoic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $28
Updated: 2025/07/31

TCI Chemical

Product number: C2726
Product name: 2-Chloro-4-(methylsulfonyl)benzoic Acid
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $77
Updated: 2025/07/31

Frontier Specialty Chemicals

Product number: JK365148
Product name: 2-Chloro-4-(methylsulfonyl)benzoic Acid
Purity: 95%
Packaging: 1g
Price: $13
Updated: 2021/12/16

AK Scientific

Product number: C168
Product name: 2-Chloro-4-(methylsulfonyl)benzoic Acid
Packaging: 5g
Price: $14
Updated: 2021/12/16

Apolloscientific

Product number: OR0264
Product name: 2-Chloro-4-(methylsulphonyl)benzoicacid
Purity: 97%
Packaging: 5g
Price: $15
Updated: 2021/12/16

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2-Chloro-4-methylsulphonylbenzoic acid Chemical Properties,Usage,Production

Chemical Properties

WHITE TO LIGHT YELLOW OR LIGHT PINK POWDER

Synthesis

101349-95-5

53250-83-2

General procedure for the synthesis of 2-chloro-4-methylsulfonylbenzoic acid from compound (CAS:101349-95-5): acetonitrile (4 mL) and compound 5 (100 mg, 0.46 mmol) were added to a 10 mL three-necked flask and stirred until complete dissolution. After cooling the reaction mixture to 0 °C, an aqueous solution of NaClO2 (124 mg, 1.38 mmol) was slowly added. Subsequently, 1 mL of HCl (117 μL) was added and stirred for 0.5 h at 0 °C. The reaction system was warmed up to 80 °C and stirring was continued for 0.5 hours. The reaction progress was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was cooled to room temperature. The reaction mixture was dried with acetonitrile, the pH was adjusted to 2 with 1N HCl aqueous solution and then the organic phase was separated by extraction with ethyl acetate and water. The organic phase was dried with anhydrous Na2SO4 and concentrated under reduced pressure to remove the organic solvent to give the crude product. The crude product was purified by column chromatography using petroleum ether and ethyl acetate (1:1, v/v) as eluents, and concentrated under reduced pressure (5 torr) to give compound 32 as a white solid (50 mg, 46.6% yield).

References

[1] Patent: CN107556289, 2018, A. Location in patent: Paragraph 0142; 0144; 0145; 0146

2-Chloro-4-methylsulphonylbenzoic acid Preparation Products And Raw materials

Raw materials

Sodium sulfate

Preparation Products

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View Lastest Price from 2-Chloro-4-methylsulphonylbenzoic acid manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 2-Chloro-4-methylsulphonylbenzoic acid 53250-83-2
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-12-03

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Chloro-4-methylsulphonylbenzoic acid 53250-83-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-25

Henan Fengda Chemical Co., Ltd

Product: 2-Chloro-4-methylsulphonylbenzoic acid 53250-83-2
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-15

53250-83-2, 2-Chloro-4-methylsulphonylbenzoic acidRelated Search:

Thiamphenicol Dimethyl sulfone 4-(Chloromethyl)benzoic acid Sulfosulfuron 4-Methylsulphonylbenzoic acid Chlorosulfonyl isocyanate Phenylmethylsulfonyl fluoride 2-Nitro-4-methylsulfonyltoluene Florfenicol 3-Chloroperoxybenzoic acid Difluorochloromethane Benzoic acid RARECHEM AL BF 1445 2,3-DICHLORO-4-(ETHYLSULFONYL)BENZENECARBOXYLIC ACID METHYL 2-CHLORO-3-METHYL-4-METHYLSULFONYLBENZOATE 2-Chloro-4-methylsulphonylbenzoic acid AQUANTRAAL BENZOICACID

TIMTEC-BB SBB003254

RARECHEM AL BE 1445

2-CHLORO-4-METHYLSULPHONYLBENZOIC ACID

2-CHLORO-4-(METHYLSULFONYL)BENZOIC ACID

2-CHLORO-4-(METHANESULFONYL)BENZOIC ACID

2-Chlor-4-(methylsulfonyl)benzoesure

2-CHLORO-4-(METHYLSULFONYL)BENZOIC ACID (DRY BASIS)

2-Chloro-4-(methylsulfonyl)benzoic acid, 95% (dry basis)

2-Chloro-4-mesylbenzoic acid

4-[Methylsulfonyl]-2-chlorobenzoic acid

2-Chloro-4-methylsulphonylbenzoic acid,95%

2-Chloro-4-methylsul

4-Carboxy-3-chlorophenyl methyl sulphone

2 - chloro - 4 - thiaMphenicol base benzoic acid

2-chloro-4-sulfonyl acid

2-Chloro-4-Met

Vismodegib int-2 2-chloro-4-(methylsulfonyl)benzoic acid

2-chloro-4-methylsulfonylbenzoate

2-Chloro-4-methanesulfonyl-benzoic ac

2-Chloro-4-(methylsulfonyl)benzoic Acid &gt

2-Chloro-4-methylsulfonylbenzoic a

Benzoic acid, 2-chloro-4-(methylsulfonyl)-

2-Chloro-4-(Methylsulfonyl)BenzoicAci

Factory Direct Sales 2-Chloro-4-Methylsulphonylbenzoic Acid CAS 53250-83-2

2-Chloro-4-(methylsulfonyl)benzoic acid, 96%,

Bupropion Impurity 46

C11447000 2-Chloro-4-methylsulfonylbenzoiCac

53250-83-2

53280-83-2

13324-35-7

C8H7CIO4S

C8H7O4ClS

ARYL ACID

Carboxylic Acids

Phenyls & Phenyl-Het

Carboxylic Acids

Phenyls & Phenyl-Het

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