ChemicalBook > CAS DataBase List > N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE

N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE

Product Name: N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE
CAS No.: 70967-90-7
Chemical Name: N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE
Synonyms: M4765;MeOSuc-AAPV-pNA;MEOSUC-ALA-ALA-PRO-VAL-PNA;LEUKOCYTE ESTERASE SUBSTRATE;ELASTASE SUBSTRATE I, COLORIMETRIC;MeOSuc-AAPV-pNA, Chromogenic Substrate;MEO-SUC-ALA-ALA-PRO-VAL-PARANITROANILIDE;METHOXYSUCCINYL-ALA-ALA-PRO-VAL-P-NITROANILIDE;N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE;N-(Methoxysuccinyl)-Ala-Ala-Pro-Val 4-nitroanilide
CBNumber: CB1725814
Molecular Formula: C27H38N6O9
Formula Weight: 590.63
MOL File: 70967-90-7.mol

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N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE Property

Melting point:: 203-205°C
Boiling point:: 958.4±65.0 °C(Predicted)
Density: 1.297±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMF: 25 mg/mL, clear, light yellow
form: Off-white solid
pka: 13.29±0.20(Predicted)
color: White to Off-White
Appearance: White Solid
Water Solubility: water: 1mg/mL
BRN: 6266359
InChIKey: YEGSVRNITOBIRO-OSAZLGQLSA-N
SMILES: C(N)(=O)[C@H](C(C)C)N(C(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)CCC(OC)=O)C1=CC=C([N+]([O-])=O)C=C1

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
F: 10-21

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 454454
Product name: N-Methoxysuccinyl-Ala-Ala-Pro-Val p-nitroanilide
Purity: Soluble, specific substrate for human leukocyte elastase.
Packaging: 50mg
Price: $159
Updated: 2025/07/31

Sigma-Aldrich

Product number: 324696
Product name: Elastase Substrate I, Colorimetric
Purity: A specific chromogenic substrate for human neutrophil elastase.
Packaging: 10mg
Price: $85.1
Updated: 2025/07/31

Cayman Chemical

Product number: 17601
Product name: MeOSuc-AAPV-pNA
Purity: ≥98%
Packaging: 5mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 17601
Product name: MeOSuc-AAPV-pNA
Purity: ≥98%
Packaging: 10mg
Price: $57
Updated: 2024/03/01

Sigma-Aldrich

Product number: M4765
Product name: N-Methoxysuccinyl-Ala-Ala-Pro-Val p-nitroanilide
Purity: elastase substrate
Packaging: 10mg
Price: $111
Updated: 2025/07/31

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N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE Chemical Properties,Usage,Production

Description

Proteinase 3 (PR3, myeloblastin) is a polymorphonuclear leukocyte serine proteinase that degrades matrix proteins including fibronectin, laminin, vitronectin, and collagen type IV to generate antimicrobial peptides. Neutrophil elastase is a serine proteinase that is secreted by neutrophils during inflammation to destroy pathogens. Evaluating these enzymes is helpful to understanding inflammatory autoimmune processes. MeOSuc-AAPV-pNA is a highly sensitive peptide substrate that is hydrolyzed by both human and mouse neutrophil elastase and PR3, but not cathepsin G or chymotrypsin. Enzyme activity can be quantified by colorimetric detection of free p-nitroanilide at 405 nm.

Uses

N-Methoxysuccinyl-Ala-Ala-Pro-Val p-Nitroanilide is a highly sensitive peptide substrate that is hydrolyzed by both human and mouse neutrophil elastase and PR3 but not cathespin.

References

[1] OLAF WIESNER . Differences between human proteinase 3 and neutrophil elastase and their murine homologues are relevant for murine model experiments[J]. FEBS Letters, 2005, 579 24: Pages 5305-5312. DOI: 10.1016/j.febslet.2005.08.056
[2] B. KORKMAZ. Discriminating between the Activities of Human Neutrophil Elastase and Proteinase 3 Using Serpin-derived Fluorogenic Substrates*[J]. The Journal of Biological Chemistry, 2002, 7 1: 39074-39081. DOI: 10.1074/jbc.m202918200

Sequene

MeOSuc-Ala-Ala-Pro-Val-pNA

N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE manufacturers

Career Henan Chemical Co

Product: N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE 70967-90-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-18

70967-90-7, N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDERelated Search:

Elastase Methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide, Methanol AC-ALA-ALA-ALA-PNA AC-ALA-ALA-PRO-ALA-PNA AC-ALA-ALA-PRO-VAL-PNA MEOSUC-LYS(2-PICOLINOYL)-ALA-PRO-VAL-PNA SUC-ALA-ALA-PRO-VAL-PNA H-VAL-PNA AC-ALA-PRO-ALA-PNA N-(4-AMINOPHENYL)-3-METHYLBUTANAMIDE N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE SUC-ALA-ALA-PRO-ALA-PNA

N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE

N-(METHOXYSUCCINYL)-L-ALANYL-L-ALANYL-L-PROLYL-L-VALINE 4-NITROANILIDE

ELASTASE SUBSTRATE I, COLORIMETRIC

MEO-SUC-ALA-ALA-PRO-VAL-PARANITROANILIDE

MEOSUC-ALA-ALA-PRO-VAL-PNA

METHOXYSUCCINYL-ALA-ALA-PRO-VAL-P-NITROANILIDE

METHOXYSUCCINYL-ALA-ALA-PRO-VAL-P-NITROANILIDE, METHANOL ADDUCT

L-Valinamide, N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-nitrophenyl)-

N-methoxysuccinyl-alanyl-alanyl-prolyl-valine-4-nitroanilide

N(methoxysuccinyl)-L-alanyl-L-alanyl-L-prolyl-L-valine NA

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val 4-nitroanilide, N-(Methoxysuccinyl)-L-alanyl-L-alanyl-L-prolyl-L-valine 4-nitroanilide

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val 4-nitroanilide

MeOSuc-AAPV-pNA, Chromogenic Substrate

MeOSuc-AAPV-pNA

M4765

N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE, BIOCHEMIKA

LEUKOCYTE ESTERASE SUBSTRATE

Elastase Substrate I, Colorimetric - CAS 70967-90-7 - Calbiochem

Methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide - CAS 70967-90-7 - Calbiochem

methyl 4-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-3-methyl-1-(4-nitroanilino)-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoate

N-(4-Methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-nitrophenyl)-L-valinamide

Methoxysuccinyl-Ala-Ala-Pro-Val-<i>p-</i>nitroanilide

Methyl 4-(((S)-1-(((S)-1-((S)-2-(((S)-3-methyl-1-((4-nitrophenyl)amino)-1-oxobutan-2-yl)carbamoyl)pyrrolidin-1-yl)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)amino)-4-oxobutanoate

70967-90-7

C27H38N6O9

BioChemical

Biochemicals and Reagents

Substrates by Enzyme

Enzyme Substrates

Enzymes, Inhibitors, and Substrates

Elastase, leukocyte