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Elastase

Product Name
Elastase
CAS No.
9004-06-2
Chemical Name
Elastase
Synonyms
ELA2;ELANE;elaszym;ELASTASE;Eiastase;Elastase-2;e.c.3.4.4.7;Elastase ES;EC 3.4.21.37;EC 3.4.21.36
CBNumber
CB2398822
Formula Weight
0
MOL File
Mol file
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Elastase Property

storage temp. 
-20°C
form 
lyophilized powder
color 
White to off-white
CAS DataBase Reference
9004-06-2
EPA Substance Registry System
Elastase (9004-06-2)
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Safety

Hazard Codes 
B
WGK Germany 
3
3-10
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SAB1305716
Product name
ANTI-NEUTROPHIL ELASTASE(N-TERMINAL) antibody produced in rabbit
Purity
affinity isolated antibody, buffered aqueous solution
Packaging
400μl
Price
$481
Updated
2024/03/01
Sigma-Aldrich
Product number
E8140
Product name
Elastase from human leukocytes
Purity
lyophilized powder, ≥50?units/mg protein (Bradford)
Packaging
1unit
Price
$228
Updated
2024/03/01
Sigma-Aldrich
Product number
324681
Product name
Elastase, Human Neutrophil
Purity
Elastase, Human Neutrophil, CAS 9004-06-2, is a serine protease that degrades elastin, collagen, and proteoglycans
Packaging
50μg
Price
$318
Updated
2024/03/01
Sigma-Aldrich
Product number
324681
Product name
Elastase, Human Neutrophil
Purity
Elastase, Human Neutrophil, CAS 9004-06-2, is a serine protease that degrades elastin, collagen, and proteoglycans
Packaging
100μg
Price
$513
Updated
2024/03/01
Usbiological
Product number
E2255-25
Product name
Elastase, Human Neutrophil
Packaging
100ug
Price
$583
Updated
2021/12/16
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Elastase Chemical Properties,Usage,Production

Uses

Elastase from human leukocytes has been used:

  • to measure serum elastase activity
  • in proteolytic digestion of fibronectin and salivary glands
  • in neutrophil elastase (NE) activity assay
  • cell-free NE digestion of E-cadherin
  • scratch wound assay
  • in a study that determined that fragments of Nle3-angiotensin(1-7) accelerate healing in dermal models
Elastase has been used to digest fibronectin. The results were compared with fibronectin digestion by crude human leukocyte homogenate to examine the presence of fibronectin peptides in saliva of patients with Sj?gren′s syndrome. It has also been used as a reference to determine the elastase activity in cell lysates. This study examined the effect of all-trans retinoic acid on procoagulant and fibrinolytic activities of cultured blast cells. These blast cells were from patients with acute promyelocytic leukemia.

General Description

Elastase is a proteolytic enzyme. It is a member of the subgroup named, peptidyl peptide hydrolases. It is a major anatomic constituent of arteries. It is mainly found in the pancreas and pancreatic juice of various birds and mammals. It is also present in human serum, granulocytes and erythrocytes.

Biochem/physiol Actions

Elastase enzyme is capable of releasing soluble peptides from insoluble elastin fibers with the help of a proteolytic process. It can stimulate disintegration of the axoneme with the help of adenosine triphosphate (ATP). Unlike pancreatic elastase the leukocyte enzyme has a preferential cleavage for the carboxyl side of valine, but will also cleave to a lesser extent after alanine. Natural substrates include elastin, cartilage proteoglycans, collagen types I, II, II and IV, and fibronectin.

Elastase Preparation Products And Raw materials

Raw materials

Preparation Products

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Elastase Suppliers

Greek Shandong Pharmaceutical Co., Ltd.
Tel
010-63830020
Country
China
ProdList
3
Advantage
60
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2872
Advantage
58
Wuhan DKY Technology Co.,Ltd.
Tel
27-81302488 18007166089
Fax
027-81302088
Email
info@dkybpc.com
Country
China
ProdList
2024
Advantage
58
Hubei XinyuanShun Chemical Co., Ltd.
Tel
13971561712, 13995564702, 027-50664929
Fax
027-50664927
Email
hbeixys2001@163.com
Country
China
ProdList
3120
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Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Raw material medicin reagent co.,Ltd
Tel
Email
sales@njromanme.com
Country
China
ProdList
4529
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58
Wuhan Runzeweiye Technology Co., Ltd.
Tel
15172337137 15172337137
Fax
027-50779735
Email
940329747@qq.com
Country
China
ProdList
634
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55

9004-06-2, ElastaseRelated Search:


  • neutrophil elastase
  • PANCREATOPEPTIDASE E
  • LYSOSOMAL ELASTASE
  • macrophage metalloelastase
  • EC 3.4.21.36
  • EC 3.4.21.37
  • ELASTASE
  • ELASTASE, LEUKOCYTE
  • ELASTASE, NEUTROPHIL, HUMAN
  • ELASTASE, HUMAN NEUTROPHIL
  • ELASTASE, HUMAN NEUTROPHILS
  • elaszym
  • LEUKOCYTE ELASTASE, HUMAN NEUTROPHILS
  • e.c.3.4.4.7
  • elastolytic enzyme
  • pancre-atopeptidase
  • elastase from human leukocytes
  • Eiastase
  • ELASTASE, LEUKOCYTE FROM HUMAN*LEUKOCYTE S
  • ELASTASE 2X-CRYSTALLIZED
  • ELASTASE FROM PORCINE PANCREAS LYOPHILIZED POWDER
  • ELASTASE FROM HUMAN NEUTROPHILS (WHITE LEUCOCYTES)ACTIVITY: 18-30 UNITS/MG PROTEIN SALT-FREE, LYOPHILIZED SOLID 98% BY SDS-PAGE
  • Elastase ES
  • 3-(4-hydroxy-2,3-dimethoxy-phenyl)-3,4-dihydro-2H-chromen-7-ol
  • 3-(4-hydroxy-2,3-dimethoxyphenyl)-3,4-dihydro-2H-chromen-7-ol
  • 3-(4-hydroxy-2,3-dimethoxy-phenyl)chroman-7-ol
  • Elastase from human neutrophils min. 10 U/mg
  • ANTI-NEUTROPHIL ELASTASE(N-TERMINAL) antibody produced in rabbit
  • Bone marrow serine protease
  • ELA2
  • ELANE
  • Elastase-2
  • Elastasefromhumanneutrophils(whiteleucocytes),activity:18-30u/mgproteinsalt-free,lyophilizedsolid
  • fromporcinepancreaslyophilizedpowder
  • Elastase from porcine pancreas, lyophil.
  • Elastase froM huMan neutrophils Min. 10 U/Mg lyophil.
  • Elastase, human leucocytes
  • 9004-06-2
  • 9004-02-6
  • 9004-6-2
  • Enzymes, Inhibitors, and Substrates
  • BioChemical
  • Biochemicals and Reagents
  • Proteolytic Enzymes and Substrates
  • Proteolytic Enzymes