1,4-Benzodioxan-6-amine

Product Name: 1,4-Benzodioxan-6-amine
CAS No.: 22013-33-8
Chemical Name: 1,4-Benzodioxan-6-amine
Synonyms: 2,3-dihydrobenzo[b][1,4]dioxin-6-amine;2,3-DIHYDRO-1,4-BENZODIOXIN-6-AMINE;AKOS AUF02030;AKOS BBS-00000780;LABOTEST-BB LT00012696;-Amino-1,4-benzodioxan;3,4-ETHYLENDIOXYANILINE;6-AMINO-1,4-BENZODIOXAN;1,4-BENZODIOXAN-6-AMINE;3,4-ETHYLENEDIOXYANILINE
CBNumber: CB1727515
Molecular Formula: C8H9NO2
Formula Weight: 151.16
MOL File: 22013-33-8.mol

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1,4-Benzodioxan-6-amine Property

Melting point:: 29-31 °C (lit.)
Boiling point:: 116-118°C 3mm
Density: 1.231 g/mL (lit.)
refractive index: n20/D 1.599(lit.)
Flash point:: >230 °F
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
form: Viscous Liquid After Melting
pka: 4.83±0.20(Predicted)
Specific Gravity: 1.231
color: Brown to black
Water Solubility: insoluble
Sensitive: Light Sensitive
BRN: 6447
InChI: InChI=1S/C8H9NO2/c9-6-1-2-7-8(5-6)11-4-3-10-7/h1-2,5H,3-4,9H2
InChIKey: BZKOZYWGZKRTIB-UHFFFAOYSA-N
SMILES: O1C2=CC=C(N)C=C2OCC1
CAS DataBase Reference: 22013-33-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/21/22-36/37/38-38
Safety Statements: 26-37/39-36/37-36
RIDADR: 2810
WGK Germany: 3
Hazard Note: Harmful
HazardClass: 6.1
PackingGroup: III
HS Code: 29329995

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 193232
Product name: 1,4-Benzodioxan-6-amine
Purity: ≥98%
Packaging: 10g
Price: $80.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: 193232
Product name: 1,4-Benzodioxan-6-amine
Purity: ≥98%
Packaging: 50g
Price: $311
Updated: 2023/06/20

TCI Chemical

Product number: E0385
Product name: 3,4-Ethylenedioxyaniline
Purity: >98.0%(GC)(T)
Packaging: 25mL
Price: $138
Updated: 2025/07/31

Usbiological

Product number: 160780
Product name: 3,4-Ethylenedioxyaniline
Packaging: 1g
Price: $418
Updated: 2021/12/16

TRC

Product number: E678600
Product name: 3,4-Ethylenedioxyaniline
Packaging: 10g
Price: $1055
Updated: 2021/12/16

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1,4-Benzodioxan-6-amine Chemical Properties,Usage,Production

Chemical Properties

brown to black viscous liquid after melting

Uses

1,4-Benzodioxan-6-amine was used in the synthesis of N-(2-hydroxy-ethyl)-2,3-didehydroazapodophyllotoxins having anti-tumor activity and dioxanoacridinones.

Uses

3,4-Ethylenedioxyaniline is a probe fragment screened to identify its ability to induce a conformation in HIV-1 transactivation response element (TAR) RNA in efforts to develop TAR-binding antiviral d rugs.

Synthesis

16498-20-7

22013-33-8

(3) In a 2L autoclave, 102.0 g (0.54 mol) of 6-nitro-2,3-dihydrobenzo[b][1,4]dioxane (Intermediate 2) and 3.7 g of palladium/carbon catalyst were added, 700 g of tetrahydrofuran (THF), and the reaction was carried out at a temperature of 40~45°C and a pressure of 5~7 atm of hydrogen for 10 h. Upon completion of the reaction, the palladium/carbon catalyst was filtered and recovered. After the reaction, the filtrate was distilled under reduced pressure to remove THF to give 62.2 g of reddish brown oily liquid (Intermediate 3) in 76.3% yield.

References

[1] Catalysis Science and Technology, 2016, vol. 6, # 1, p. 152 - 160
[2] Chemical Communications, 2012, vol. 48, # 64, p. 7982 - 7984
[3] Dalton Transactions, 2016, vol. 45, # 17, p. 7421 - 7426
[4] Patent: CN105859678, 2016, A. Location in patent: Paragraph 0078; 0079
[5] Russian Chemical Bulletin, 2009, vol. 58, # 6, p. 1233 - 1240

1,4-Benzodioxan-6-amine Preparation Products And Raw materials

Raw materials

Preparation Products

2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL ISOTHIOCYANATE

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1,4-Benzodioxan-6-amine Suppliers

Americas 1 Belgium 2 Canada 2 China 104 Europe 2 France 1 Germany 10 India 29 Japan 3 Slovakia 1 South Korea 1 Switzerland 4 Ukraine 1 United Kingdom 14 United States 31 Global 206

Shijiazhuang Benchu Technology Co., Ltd.

Tel: 173-0311-68015059-6798 17367983103
Email: 925646462@qq.com
Country: China
ProdList: 30
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Shanghai Harvest Chemical Industrial Co., Ltd.

Tel: 021-31038972,31038973 17321035817
Fax: +86-21-51385350
Email: sales@harvest-chem.com
Country: China
ProdList: 2816
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11705
Advantage: 57

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View Lastest Price from 1,4-Benzodioxan-6-amine manufacturers

R&D Scientific Inc.

Product: 2,3-dihydro-1,4-benzodioxin-6-amine 22013-33-8
Price: US $1500.00/g
Min. Order: 1g
Purity: 99 %
Supply Ability: 500 Kg
Release date: 2024-11-15

Career Henan Chemical Co

Product: 1,4-Benzodioxan-6-amine 22013-33-8
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2020-01-08

22013-33-8, 1,4-Benzodioxan-6-amineRelated Search:

Triethanolamine Sulfanilamide 4-Aminobenzoic acid Sulfanilic acid Glycine Dibenzylamine 3-Aminophenol 6-Aminocaproic acid p-Anisidine 4-Dimethylaminobenzaldehyde 4,4'-Methylenedianiline Bis(2-ethylhexyl)amine Aniline Triallylamine ALTRENOGEST Tris(hydroxymethyl)aminomethane Anthranilic acid 2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL ISOTHIOCYANATE

LABOTEST-BB LT00012696

6-AMINO-1,4-BENZODIOXAN

6-AMINO-1,4-BENZODIOXANE

2,3-DIHYDRO-1,4-BENZODIOXIN-6-AMINE

AKOS AUF02030

AKOS BBS-00000780

3,4-ETHYLENDIOXYANILINE

3,4-ETHYLENEDIOXYANILINE

1,4-BENZODIOXAN-6-AMINE

1,4-BENZODIOXAN-6-YLAMINE

6-Amino-1,4-benzodioxane~1,4-Benzodioxan-6-amine

1,4-Benzodioxane-6-amine

1,4-Benzodioxin-6-amine, 2,3-dihydro-

1,4-BENZODIOXAN-6-AMINE 99%

2,3-Dihydro-1,4-benzodioxin-7-amine

3,4-Ethylenedioxyaniline ,99%

6-Amino-2,3-dihydro-1,4-benzodioxin

1,4-Benzodioxan-6-amine,99%

2,3-Dihydrobenzo[1,4]dioxin-6-ylamine

-Amino-1,4-benzodioxan

2,3-dihydrobenzo[b][1,4]dioxin-6-amine

6-Amino-2,3-dihydro-1,4-benzodioxine

6-Amino-1,4-benzodioxan,3,4-(Ethylenedioxy)aniline

3,4-Ethylenedioxyaniline, 2,3-Dihydro-1,4-benzodioxin-6-amine, 6-Amino-1,4-benzodioxane

1,4-Benzodioxan-6-aMine, 99% 50GR

1,4-Benzodioxan-6-aMine, 99% 5GR

6-AMINO-1,4-BENZODIOXANE FOR SYNTHESIS

1,4-Benzodioxan-6-amine >=98%

2,3,4a,8a-tetrahydro-1,4-benzodioxin-6-amine

3,4-Ethylenedioxyaniline&gt

3,4-Ethylenedioxyaniline, 95%

22013-33-8

22013-38-6

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