N-Methyl-D-prolinol

Product Name: N-Methyl-D-prolinol
CAS No.: 99494-01-6
Chemical Name: N-Methyl-D-prolinol
Synonyms: -D-proL;1-Methyl-D-prolinol;N-METHYL-D-PROLINOL;N-Methyl-D-Prolinol,>98%;N-Methyl-D-prolinol USP/EP/BP;(R)-1-METHYL-2-PYRROLIDINEMETHANOL;(R)-N-methylpyrrolidine-2-methanol;(?-1-Methylpyrrolidin-2-yl)methanol;((R)-1-methylpyrrolidin-2-yl)methanol;[(2R)-1-methyl-2-pyrrolidinyl]methanol
CBNumber: CB1728183
Molecular Formula: C6H13NO
Formula Weight: 115.17
MOL File: 99494-01-6.mol

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N-Methyl-D-prolinol Property

Density: 0.971 g/mL at 25 °C
refractive index: n20/D4.469
Flash point:: 71℃
storage temp.: 2-8°C
pka: 14.77±0.10(Predicted)
form: liquid
Appearance: Colorless to light yellow Liquid
optical activity: Consistent with structure
Boiling point:: 68-71°C(lit.)
InChI: InChI=1S/C6H13NO/c1-7-4-2-3-6(7)5-8/h6,8H,2-5H2,1H3/t6-/m1/s1
InChIKey: VCOJPHPOVDIRJK-ZCFIWIBFSA-N
SMILES: N1(C)CCC[C@@H]1CO

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Safety

Hazard Codes: Xn
Risk Statements: 22-37/38-41
Safety Statements: 26-39
RIDADR: NA 1993 / PGIII
WGK Germany: 3
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 761990
Product name: (R)-1-Methyl-2-pyrrolidinemethanol
Purity: 97%
Packaging: 1g
Price: $101
Updated: 2025/07/31

TRC

Product number: M327288
Product name: N-Methyl-D-prolinol
Packaging: 50mg
Price: $45
Updated: 2021/12/16

ChemScene

Product number: CS-W003381
Product name: N-Methyl-D-prolinol
Purity: 99.07%
Packaging: 25g
Price: $53
Updated: 2021/12/16

Matrix Scientific

Product number: 075179
Product name: N-Methyl-D-prolinol
Purity: 95+%
Packaging: 5g
Price: $63
Updated: 2021/12/16

Apolloscientific

Product number: OR315047
Product name: N-Methyl-D-prolinol
Packaging: 5g
Price: $102
Updated: 2021/12/16

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N-Methyl-D-prolinol Chemical Properties,Usage,Production

Uses

N-Methyl-D-prolinol is used as a pharmaceutical or synthetic intermediate component in the preparation of organic compounds such as nitrogen-containing heterocyclic compounds, pyrotinib intermediate and anidulafungin derivative.

Synthesis

59378-81-3

3554-65-2

Step 1: Preparation of [(2R)-1-methylpyrrolidin-2-yl]methanol Lithium aluminum hydride (230 mg, 6 mmol) and N-tert-butoxycarbonyl-R-prolinol (400 mg, 2 mmol) were dissolved in 10 mL of dry tetrahydrofuran and cooled in an ice water bath. After no significant gas release, the reaction mixture was heated to reflux and maintained for 2 hours. Upon completion of the reaction, the mixture was slowly added dropwise to 5 mL of methanol in an ice-water bath, followed by the addition of 5 mL of water. The mixture was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford N-methyl-D-prolinol [(2R)-1-methylpyrrolidin-2-yl]methanol (221 mg, 77.0% yield) as a colorless oil. Mass spectrum (ESI) m/z: 116 [M + 1].

References

[1] Patent: US2013/338190, 2013, A1. Location in patent: Paragraph 0037; 0038
[2] Patent: EP2684877, 2014, A2. Location in patent: Page/Page column 0032; 0033
[3] Patent: TWI524893, 2016, B. Location in patent: Page/Page column 44; 45
[4] Patent: WO2018/31877, 2018, A1. Location in patent: Paragraph 00150

N-Methyl-D-prolinol Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Methyl-D-prolinol Suppliers

China 107 Germany 1 India 2 United Kingdom 4 United States 21 Global 135

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View Lastest Price from N-Methyl-D-prolinol manufacturers

Career Henan Chemical Co

Product: N-Methyl-D-prolinol 99494-01-6
Price: US $1.00/KG
Min. Order: 1IU
Purity: 99%
Supply Ability: 100kg
Release date: 2019-12-24

99494-01-6, N-Methyl-D-prolinolRelated Search:

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((R)-1-methylpyrrolidin-2-yl)methanol

N-METHYL-D-PROLINOL

(R)-1-METHYL-2-PYRROLIDINEMETHANOL

(R)-(-)-(1-METHYL-2-PYRROLIDINYL)METHANOL

[(2R)-1-Methylpyrrolidin-2-yl]Methanol

(R)-2-Hydroxymethyl-1-methylpyrrolidine

1-Methyl-D-prolinol

[(2R)-1-methyl-2-pyrrolidinyl]methanol

(R)-N-methylpyrrolidine-2-methanol

N-Methyl-D-Prolinol,>98%

-D-proL

2-Pyrrolidinemethanol, 1-methyl-, (2R)-

N-Methyl-D-prolinol USP/EP/BP

(?-1-Methylpyrrolidin-2-yl)methanol

(<i>R</i>)-1-Methyl-2-pyrrolidinemethanol

99494-01-6