ChemicalBook > CAS DataBase List > 2,4,5-Trifluorobenzoic acid

2,4,5-Trifluorobenzoic acid

Product Name
2,4,5-Trifluorobenzoic acid
CAS No.
446-17-3
Chemical Name
2,4,5-Trifluorobenzoic acid
Synonyms
2,4,5-Trilfuorobenzoic acid;2,4,5-TrifL;RARECHEM AL BO 0258;2,4,5-Trifluorobenzo;5-Trifluorobenzoic acid;2,4,5-tifluorobenzoicacid;2,4,5-TRIFLUOROBENZOIC ACID;Benzoic acid, 2,4,5-trifluoro-;2,4,5-Trifluorobenzoic acid 99%;2,4,5-Trifluorobenzoic acid ,99%
CBNumber
CB1742985
Molecular Formula
C7H3F3O2
Formula Weight
176.09
MOL File
446-17-3.mol
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2,4,5-Trifluorobenzoic acid Property

Melting point:
94-96 °C (lit.)
Boiling point:
241.9±35.0 °C(Predicted)
Density 
1.4362 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), DMSO (Slightly)
form 
Solid
pka
2.87±0.10(Predicted)
color 
Off-White
BRN 
3257609
InChIKey
AKAMNXFLKYKFOJ-UHFFFAOYSA-N
CAS DataBase Reference
446-17-3(CAS DataBase Reference)
EPA Substance Registry System
Benzoic acid, 2,4,5-trifluoro- (446-17-3)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29163990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
328154
Product name
2,4,5-Trifluorobenzoic acid
Purity
99%
Packaging
5g
Price
$25.62
Updated
2024/03/01
TCI Chemical
Product number
T1586
Product name
2,4,5-Trifluorobenzoic Acid
Purity
>97.0%(GC)(T)
Packaging
5g
Price
$54
Updated
2024/03/01
TCI Chemical
Product number
T1586
Product name
2,4,5-Trifluorobenzoic Acid
Purity
>97.0%(GC)(T)
Packaging
25g
Price
$216
Updated
2024/03/01
Alfa Aesar
Product number
A14193
Product name
2,4,5-Trifluorobenzoic acid, 98%
Packaging
5g
Price
$94.65
Updated
2024/03/01
Alfa Aesar
Product number
A14193
Product name
2,4,5-Trifluorobenzoic acid, 98%
Packaging
1g
Price
$30.5
Updated
2021/12/16
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2,4,5-Trifluorobenzoic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

2,4,5-Trifluorobenzoic Acid is a useful synthetic intermediate. It can be used to synthesize quinolone antibacterial agnts.

Preparation

Synthesis of 2,4,5-trifluorobenzoic acid: Tetrachloroisophthalonitrile was used as the starting material, which was fluoridated, selectively reduced, and partially defluoridated to obtain 2,4,5-trifluoroisophthalonitrile. This compound was hydrolyzed to form 2,4,5-trifluoroisophthalic acid. Then, selective decarboxylation of 2,4,5-trifluorobenzoic acid was carried out to prepare 2,4,5-trifluorobenzoic acid.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 34, p. 168, 1991 DOI: 10.1021/jm00105a025

General Description

2,4,5-Trifluorobenzoic acid is an important quinolone antibacterial intermediate. It is used in the synthesis of Temafloxacin and liquid crystals, among others.

2,4,5-Trifluorobenzoic acid Preparation Products And Raw materials

Raw materials

1,2,4-Trifluorobenzene Isophthalic acid Chlorothalonil 2,4-Difluoroaniline

Preparation Products

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View Lastest Price from 2,4,5-Trifluorobenzoic acid manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
2,4,5-Trifluorobenzoic acid 446-17-3
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-06
Speranza Chemical Co., Ltd.
Product
2,4,5-trifluorobenzoic acid 446-17-3
Price
US $20.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
446-17-3
Release date
2019-12-24
Hebei Weibang Biotechnology Co., Ltd
Product
2,4,5-Trifluorobenzoic acid 446-17-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-10-24

446-17-3, 2,4,5-Trifluorobenzoic acidRelated Search:

ALUMINUM FORMATE 3-(Trifluoromethyl)benzoic acid Triethyl orthoformate Florfenicol Trimethoxymethane Pentafluorobenzoic acid Trimesic acid 4-Fluorobenzoic acid 1,3,5-Trifluorobenzene 2,4,5-Trifluorobenzyl alcohol 2,3,4-Trifluorobenzoic acid Tetrafluorophthalic anhydride 3-HYDROXY-2,4,5-TRIFLUOROBENZOIC ACID METHYL PENTAFLUOROBENZOATE Tetrafluorophthalic acid ETHYL PENTAFLUOROBENZOATE 2,3,4,5-Tetrafluorobenzoic acid 3-METHOXY-2,4,5-TRIFLUOROBENZOIC ACID,3-Methoxy-2,4,5-Trifluorobenzoic Acid 2,4,5-Trifluoro-3-Methoxybenzoic Acid

  • 2,4-trifluorobenzoic acid and derivatives
  • 2,4,5-Trilfuorobenzoic acid
  • 2,4,5-TRIFLUOROBENZOIC ACID AND THE DERIVATIVES
  • 2,4,5-TrifluoroBenzoicacidsolution
  • 2,4,5-Trifluorobenzoic acid, 99.5+%
  • 2,4,5-Trifluorobenzoic acid 20% solution
  • 2,4,5-Trifluorobenzoic acid 99%
  • RARECHEM AL BO 0258
  • 2,4,5-Trifluorobenzoic acid ,99%
  • 2,4,5-Trifluorobenzo
  • 2,4,5-Trifluorobenzoic acid, 99.5+%, 99.5+%
  • 5-Trifluorobenzoic acid
  • 2,4,5-tifluorobenzoicacid
  • 2,4,5-TRIFLUOROBENZOIC ACID
  • 2,4,5-TrifL
  • Benzoic acid, 2,4,5-trifluoro-
  • 446-17-3
  • Carbonyl Compounds
  • Carboxylic Acids
  • ARYL ACID
  • Organic Building Blocks
  • C7
  • Building Blocks
  • Pyridines ,Halogenated Heterocycles
  • C7
  • Carbonyl Compounds
  • Carboxylic Acids
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • Benzoic acid
  • Miscellaneous
  • blocks
  • Carboxes
  • FluoroCompounds
  • bc0001
  • OLED