4-(2-PYRIDYL)ANILINE
- Product Name
- 4-(2-PYRIDYL)ANILINE
- CAS No.
- 18471-73-3
- Chemical Name
- 4-(2-PYRIDYL)ANILINE
- Synonyms
- 4-(pyridin-2-yl)aniline;4-(2-Pyridinyl)aniline;2-(4-AMINOPHENYL)PYRIDINE;4-(2-Pyridyl);2-Pyridyl-3-aniline;4-(2-PYRIDYL)ANILINE;4-(2-Pyridyl)aminobenzene;4-Pyridin-2-yl-phenylaMine;4-(2-Pyridinyl)benzenamine;Benzenamine, 4-(2-pyridinyl)-
- CBNumber
- CB1745067
- Molecular Formula
- C11H10N2
- Formula Weight
- 170.21
- MOL File
- 18471-73-3.mol
4-(2-PYRIDYL)ANILINE Property
- Melting point:
- 95 °C
- Boiling point:
- 322.8±17.0 °C(Predicted)
- Density
- 1.133±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C, protect from light
- form
- solid
- pka
- 5.72±0.25(Predicted)
- color
- Brown
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- P991913
- Product name
- 4-(2-Pyridyl)aniline
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 074092
- Product name
- 4-(2-Pyridyl)aniline
- Purity
- 95+%
- Packaging
- 1g
- Price
- $26
- Updated
- 2021/12/16
- Product number
- 074092
- Product name
- 4-(2-Pyridyl)aniline
- Purity
- 95+%
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- W3992
- Product name
- 4-(2-Pyridyl)aniline
- Packaging
- 10g
- Price
- $133
- Updated
- 2021/12/16
- Product number
- 074092
- Product name
- 4-(2-Pyridyl)aniline
- Purity
- 95+%
- Packaging
- 10g
- Price
- $135
- Updated
- 2021/12/16
4-(2-PYRIDYL)ANILINE Chemical Properties,Usage,Production
Synthesis
4282-47-7
18471-73-3
General procedure for the synthesis of 4-(2-pyridyl)aniline from 2-(4-nitrophenyl)pyridine: the compound 2-(4-nitrophenyl)pyridine (0.2 g, 1.03 mmol) was dissolved in methanol (10 mL), 10% palladium-carbon (20 mg) was added as a catalyst, and the reduction reaction was carried out under hydrogen atmosphere. The reaction mixture was stirred at room temperature for 18 hours. Upon completion of the reaction, the catalyst was removed by filtration through a Celite pad, which was washed with methanol (50 mL). After combining the filtrates, the solvent was removed by evaporation under reduced pressure to give the crude product. The crude product was purified by rapid chromatography on silica gel with the eluent dichloromethane-methanol-ammonia (95:4.5:0.5, v/v/v) to afford the target compound 4-(2-pyridyl)aniline (0.15 g, 87% yield) as a brown solid. The physical and spectroscopic data of the product were as follows: melting point 89-92 °C (literature value 94-95 °C); IR spectra (νmax/cm?1) 3333, 3210, 1606, 1586, 1519, 1294, 1181; 1H NMR (500 MHz, CDCl?) δ 8.62 (1H, dt, J=1.0, 5.0 Hz), 7.83 (2H, d, J=8.5 Hz), 7.68-7.61 (2H, m), 7.11 (1H, m), 6.75 (2H, d, J=8.5 Hz), 3.83 (2H, br s); 13C NMR (125 MHz, CDCl?) δ 157.6, 149.5, 147.5, 136.6, 129.8, 128.1, 121.0, 119.4, 115.2; mass spectrometry (ESI) m/z 171 ([M + H]? , 100).
References
[1] European Journal of Medicinal Chemistry, 2015, vol. 95, p. 277 - 301
[2] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1988, vol. 24, # 11, p. 1221 - 1225
[3] Khimiya Geterotsiklicheskikh Soedinenii, 1988, vol. 24, # 11, p. 1476 - 1480
[4] Molecular crystals and liquid crystals, 1980, vol. 62, # 1-2, p. 103 - 114
[5] Chemische Berichte, 1896, vol. 29, p. 168
4-(2-PYRIDYL)ANILINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(2-PYRIDYL)ANILINE manufacturers
- Product
- 4-(2-PYRIDYL)ANILINE 18471-73-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-08-08