beta-Amyrin
- Product Name
- beta-Amyrin
- CAS No.
- 559-70-6
- Chemical Name
- beta-Amyrin
- Synonyms
- B-AMYRIN;β-Amyrin;β-Amyrine;AMYRIN, B-;b-Amyrenol;Nsc 527971;beta-aMyin;BETA-AMYRIN;β-Amyrin-RM;beta-Amyrenol
- CBNumber
- CB1749883
- Molecular Formula
- C30H50O
- Formula Weight
- 426.73
- MOL File
- 559-70-6.mol
beta-Amyrin Property
- Melting point:
- 187-190°C
- alpha
- D19 +99.8° (c = 1.3 in benzene)
- Boiling point:
- bp0.8 260°
- Density
- 0.9600 (rough estimate)
- refractive index
- 1.4910 (estimate)
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- pka
- 15.18±0.70(Predicted)
- color
- White to Off-White
- optical activity
- +9120 (c 1.23, CHCl3)
- BRN
- 2063468
- InChIKey
- JFSHUTJDVKUMTJ-QHPUVITPSA-N
- LogP
- 10.481 (est)
- CAS DataBase Reference
- 559-70-6(CAS DataBase Reference)
- NIST Chemistry Reference
- «BETA»-amyrin(559-70-6)
N-Bromosuccinimide Price
- Product number
- PHL80292
- Product name
- β-Amyrin
- Purity
- phyproof? Reference Substance
- Packaging
- 10MG
- Price
- $332
- Updated
- 2025/07/31
- Product number
- 09236
- Product name
- β-Amyrin
- Purity
- analytical standard
- Packaging
- 10mg
- Price
- $755
- Updated
- 2025/07/31
- Product number
- 20949
- Product name
- β-Amyrin
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $87
- Updated
- 2024/03/01
- Product number
- 20949
- Product name
- β-Amyrin
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $357
- Updated
- 2024/03/01
- Product number
- 20949
- Product name
- β-Amyrin
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $595
- Updated
- 2024/03/01
beta-Amyrin Chemical Properties,Usage,Production
Uses
nociceptive
Definition
ChEBI: A pentacyclic triterpenoid that is oleanane substituted at the 3beta-position by a hydroxy group and containing a double bond between positions 12 and 13. It is one of the most commonly occurring triterpenoids in higher plants.
Biological Activity
Triterpene th at has broad-spectrum analgesic properties for which the underlying mechanism is poorly understood.
in vivo
β-Amyrin (4 mg/kg, p.o., daily, 5 days) ameliorates object recognition memory deficit and neurogenesis impairments in the hippocampus of Aβ-induced AD model mice[1].
β-Amyrin (20-100 μg, i.p.) inhibits carrageenan-induced paw edema of rats[2].
β-Amyrin (20-80 mg/kg, i.g., daily, 5 days) has a potent efficacy in protecting against BLM-induced mice pulmonary fibrosis via suppressing inflammatory response and oxidative stress[3].
Pharmacokinetic parameters of β-Amyrin in rats
| β-Amyrin standard IV (group 3) | β-Amyrin standard oral dose (group 2) | ||
| Dose (mg kg?1) | 1 | 3 | 300 (equivalent of 3mg kg?1 β-amyrin) |
| V (ml kg?1) | 1317 | ||
| AUC0→24 h (min μg ml?1) | 411 | 10.6 | 47.3 |
| Cl (ml min?1 kg?1) | 2.04 | ||
| t1/2λZ (h) | 10.2 | 10.3 | 8.3 |
| MRT0→24 h (h) (h) | 8 | 8.5 | 8.7 |
| Cmax (ng ml?1) (h) (h) | 18.7 | 75 | |
| tmax (h) | - | 3 (n = 2) or 5 (n = 1) | 3 (n = 3) or 5 (n = 1) |
| F (%) | 0.86 | 3.83 |
| Animal Model: | Male CD-1 mice, 26-28 g, 6 weeks old. 5 μL of Aβ was acutely injected into the left lateral ventricle by hand[1]. |
| Dosage: | 4 mg/kg |
| Administration: | p.o., daily, 5 days |
| Result: | Increased number of transitions between the light and dark compartments. Increased the total exploration time on the light compartment of the apparatus and the time spent in open arms. Ameliorated the reduction of neurogenesis. |
| Animal Model: | Adult male rats of Sprague–Dawley strain, weighing 150-180 g. Carrageenan induces edema in the hind paw of the rat[2]. |
| Dosage: | 20, 50, 100 μg/kg |
| Administration: | i.p. |
| Result: | Significant decreased edema by in a dose dependent manner. |
| Animal Model: | Adult male rats of Sprague–Dawley strain, weighing 150-180 g. Carrageenan induces Use Bleomycin (BLM) (HY-108345), 5mg/kg, one-time intratracheally injection, in 50μL saline per mouse to induce the marine model of pulmonary fibrosis[3]. |
| Dosage: | 20, 40, 80 mg/kg |
| Administration: | i.g., daily, 5 days |
| Result: | Promoted the values of SO2 and PO2 and inhibited the value of PCO2. Significantly improved inflammatory cell infiltration, the thickened alveolar septum and the lesion collapses of the alveoli and formation of flaky lung tissue. |
target
GABA Receptor | P450 (e.g. CYP17) | cAMP | PKC | PKA | PGE | TNF-α | Antifection
beta-Amyrin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from beta-Amyrin manufacturers
- Product
- beta-Amyrin 559-70-6
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2020-04-27
- Product
- β-Amyrin 559-70-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 100g
- Purity
- 99%+
- Supply Ability
- 200 tons
- Release date
- 2019-12-27
- Product
- β-Amyrin 559-70-6
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 100 tons
- Release date
- 2020-01-15