ChemicalBook > CAS DataBase List > 2,2-DIFLUOROACETOPHENONE

2,2-DIFLUOROACETOPHENONE

Product Name
2,2-DIFLUOROACETOPHENONE
CAS No.
395-01-7
Chemical Name
2,2-DIFLUOROACETOPHENONE
Synonyms
2,2-DIFLUOROACETOPHENONE;A,A-DIFLUOROACETOPHENONE;2,2-Difluoroacetophenone97%;2,2-Difluoroacetophenone,95%;2,2-Difluoroacetophenone 97%;2,2-DIFLUORO-1-PHENYLETHANONE;Ethanone, 2,2-difluoro-1-phenyl-;2,2-Difluoro-1-phenylethan-1-one;ALPHA,ALPHA-DIFLUOROACETOPHENONE;Ethanone, 2,2-difluoro-1-phenyl- (9CI)
CBNumber
CB1750292
Molecular Formula
C8H6F2O
Formula Weight
156.13
MOL File
395-01-7.mol
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2,2-DIFLUOROACETOPHENONE Property

Melting point:
48-50°C
Boiling point:
53-54°C/12mm
Density 
1.180±0.06 g/mL
refractive index 
1.4955
Flash point:
53-54°C/12mm
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
liquid
Appearance
Colorless to light yellow Liquid
Water Solubility 
Immiscible with water.
CAS DataBase Reference
395-01-7
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2914790090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
793841
Product name
2,2-Difluoroacetophenone
Packaging
1g
Price
$86.9
Updated
2025/07/31
Sigma-Aldrich
Product number
793841
Product name
2,2-Difluoroacetophenone
Packaging
5g
Price
$332
Updated
2025/07/31
TRC
Product number
D445383
Product name
2,2-Difluoroacetophenone
Packaging
500mg
Price
$90
Updated
2021/12/16
TRC
Product number
D445383
Product name
2,2-Difluoroacetophenone
Packaging
100mg
Price
$60
Updated
2021/12/16
SynQuest Laboratories
Product number
2617-3-32
Product name
2,2-Difluoroacetophenone
Purity
97%
Packaging
1g
Price
$65
Updated
2021/12/16
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2,2-DIFLUOROACETOPHENONE Chemical Properties,Usage,Production

Uses

2,2-Difluoroacetophenone acts as an intermediate in the preparation of various substances such as pharmaceuticals. Further, it is used in the one-pot synthesis of difluoromethylated arenes from aryl chlorides and bromides. In addition to this, it undergoes reduction with (-)-diisopinocampheylchloroborane chloride to get R-alcohols of purity 85% ee.

Synthesis Reference(s)

Tetrahedron, 52, p. 15, 1996 DOI: 10.1016/0040-4020(95)00884-B

2,2-DIFLUOROACETOPHENONE Preparation Products And Raw materials

Raw materials

Preparation Products

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395-01-7, 2,2-DIFLUOROACETOPHENONERelated Search:

4-(TRIFLUOROACETYL)TOLUENE Trifluoroacetophenone (HEPTAFLUOROBUTYRO)PHENONE 2,2,2-TRIFLUORO-3'-(TRIFLUOROMETHYL)ACETOPHENONE 2,2,2,4'-TETRAFLUOROACETOPHENONE 1-(4-Dimethylaminophenyl)-2,2,2-trifluoroethanone 2-CHLORO-2,2-DIFLUOROACETOPHENONE,2-Chloro-2,2-difluoroacetophenone 97%,2-Chloro-2,2-difluoroacetophenone97% 2,2,2,3'-TETRAFLUOROACETOPHENONE 4-(TRIFLUOROACETYL)BENZOIC ACID 2-BROMO-2',5'-DIFLUOROACETOPHENONE 2,5-DIFLUOROACETOPHENONE,2',5'-DIFLUOROACETOPHENONE,2',5'-Difluoroacetophenone98%,2&#39,5&#39-Difluoroacetophenone 2-BROMO-2',4'-DIFLUOROACETOPHENONE a-Amino-2,4-difluoroacetophenone hydrochloride,a-Amino-2,4-difluoroacetophenone,2-AMINO-2',4'-DIFLUOROACETOPHENONE 3'-Chloro-2',6'-difluoroacetophenone 98%,3&#39-Chloro-2&#39,6&#39-difluoroacetophenone,3'-Chloro-2',6'-difluoroacetophenone98% 2-BROMO-2',6'-DIFLUOROACETOPHENONE 2'-CHLORO-2,4-DIFLUOROACETOPHENONE,2-CHLORO-2',4'-DIFLUOROACETOPHENONE 2&#39-Chloro-4&#39,5&#39-difluoroacetophenone 3&#39,5&#39-Difluoroacetophenone,3',5'-Difluoroacetophenone98%,3',5'-Difluoroacetophenone 98%

  • A,A-DIFLUOROACETOPHENONE
  • ALPHA,ALPHA-DIFLUOROACETOPHENONE
  • Ethanone, 2,2-difluoro-1-phenyl- (9CI)
  • 2,2-Difluoroacetophenone,95%
  • 2,2-Difluoro-1-phenylethan-1-one
  • 2,2-Difluoroacetophenone 97%
  • 2,2-Difluoro-1-phenylethan-1-one, 2,2-Difluoro-1-phenyl-1-oxoethane
  • 2,2-DIFLUOROACETOPHENONE
  • 2,2-DIFLUORO-1-PHENYLETHANONE
  • 2,2-Difluoroacetophenone97%
  • Ethanone, 2,2-difluoro-1-phenyl-
  • 395-01-7
  • ACETYLHALIDE