3',5'-Difluoroacetophenone

Product Name: 3',5'-Difluoroacetophenone
CAS No.: 123577-99-1
Chemical Name: 3',5'-Difluoroacetophenone
Synonyms: CAS:123577-99-1;3', 5' -difluorophenone;3,5-DIFLUOROACETOPHENONE;3',5'-Difluoroacetophenone;3',5'-Difluoroacetophenone>3',5'-Difluoroacetophenone98%;3′,5′-Difluoroacetophenone,97%;3',5'-Difluoroacetophenone 98%;1-(3,5-Difluorophenyl)ethanone;3, 5 - two fluorine acetophenone
CBNumber: CB9744132
Molecular Formula: C8H6F2O
Formula Weight: 156.13
MOL File: 123577-99-1.mol

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3',5'-Difluoroacetophenone Property

Melting point:: 34-38 °C(lit.)
Boiling point:: 94 °C
Density: 1.206±0.06 g/cm3(Predicted)
refractive index: 1.4876
Flash point:: 180 °F
storage temp.: Sealed in dry,Room Temperature
form: Low Melting Solid
color: White to slightly yellow
BRN: 6798740
InChI: InChI=1S/C8H6F2O/c1-5(11)6-2-7(9)4-8(10)3-6/h2-4H,1H3
InChIKey: OXJLDNSPGPBDCP-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC(F)=CC(F)=C1)C
CAS DataBase Reference: 123577-99-1(CAS DataBase Reference)
NIST Chemistry Reference: 3,5-Difluoroacetophenone(123577-99-1)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-R36/37/38-36-26
Safety Statements: 26-36-S36-S26-36/37/38
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29147000
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 541168
Product name: 3′,5′-Difluoroacetophenone
Purity: 97%
Packaging: 5g
Price: $55.67
Updated: 2025/07/31

TCI Chemical

Product number: D3425
Product name: 3',5'-Difluoroacetophenone
Purity: >97.0%(GC)
Packaging: 5g
Price: $28
Updated: 2025/07/31

TCI Chemical

Product number: D3425
Product name: 3',5'-Difluoroacetophenone
Purity: >97.0%(GC)
Packaging: 25g
Price: $132
Updated: 2025/07/31

TRC

Product number: D445553
Product name: 3'',5''-Difluoroacetophenone
Packaging: 2.5g
Price: $65
Updated: 2021/12/16

Apolloscientific

Product number: PC2579
Product name: 3',5'-Difluoroacetophenone
Purity: 98%
Packaging: 100g
Price: $127
Updated: 2021/12/16

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3',5'-Difluoroacetophenone Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

3′,5′-Difluoroacetophenone (3,5-Difluoroacetophenone) may be used to synthesize:

(E)-3-(4-(1,5,9-trithia-13-azacyclohexadecan-13-yl)-phenyl)-1-(3,5-difluorophenyl)prop-2-en-1-one
1,3,5-triarylpyrazoline fluorophores containing a 16-membered thiazacrown ligand
(±)-fluorinated-1-(3-morpholin-4-yl-phenyl)ethylamine
(E)-1-(3,5-difluorophenyl)-3-(2,4-dimethoxyphenyl) prop-2-en-1-one
1-(3,5-difluorophenyl)-4,4,4-trifluorobutane-1,3-dione

General Description

3′,5′-Difluoroacetophenone, also known as 1-(3,5-difluorophenyl)ethanone, is a fluorinated acetophenone.

Synthesis

872181-59-4

123577-99-1

The general procedure for the synthesis of 3,5-difluoroacetophenone from 1-(3,5-difluorophenyl)ethanol was carried out as follows: a solution of Dess-Martin periodontane (9.66 g, 22.8 mmol) was added batchwise to a solution of 1-(3,5-difluorophenyl)ethanol (3.00 g, 19.0 mmol) in dichloromethane (40 mL) under ice-bath cooling conditions. The reaction mixture was stirred at room temperature for 2 hours. Subsequently, the solvent was removed by concentration under reduced pressure. The residue was purified by silica gel column chromatography using a CombiFlash device eluting with a gradient of ethyl acetate/hexane (0-40%). Purification afforded 3,5-difluoroacetophenone (2.06 g, 69.6% yield) as a colorless oil. Its 1H NMR (300 MHz, CDCl3) data were as follows: δ 7.45 (m, 2H), 7.01 (m, 1H), 2.59 (s, 3H) ppm.

References

[1] Patent: US2014/200227, 2014, A1. Location in patent: Paragraph 1098; 1099

3',5'-Difluoroacetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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3',5'-Difluoroacetophenone Suppliers

Americas 1 Australia 1 Belgium 2 Canada 1 CHINA 200 Europe 5 France 2 Germany 7 India 11 Italy 1 Japan 5 Poland 1 Slovakia 1 Switzerland 3 Ukraine 1 United Kingdom 24 United States 54 Global 320

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View Lastest Price from 3',5'-Difluoroacetophenone manufacturers

Hebei Miaobian Biotechnology Co., Ltd

Product: 3',5'-Difluoroacetophenone 123577-99-1
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99.99
Supply Ability: 10Ton
Release date: 2020-11-09

Career Henan Chemical Co

Product: 3',5'-Difluoroacetophenone 123577-99-1
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2019-12-21

123577-99-1, 3',5'-DifluoroacetophenoneRelated Search:

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3′,5′-Difluoroacetophenone,97%

1-(3,5-difluorophenyl)ethan-1-one

3, 5 - two fluorine acetophenone

1-(3,5-Difluorophenyl)ethanone

3,5-DIFLUOROACETOPHENONE

Ethanone, 1-(3,5-difluorophenyl)- (9CI)

3',5'-Difluoroacetophenone 98%

3',5'-Difluoroacetophenone98%

3',5'-Difluoroacetophenone&gt

Ethanone, 1-(3,5-difluorophenyl)-

3', 5' -difluorophenone

3',5'-DIFLUOROACETOPHENONE 123577-99-1

3',5'-Difluoroacetophenone

CAS:123577-99-1

3′,5′-Difluoroacetophenone, CAS 123577-99-1

123577-99-1

3764-01-9

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C7-C8

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