(S)-(+)-1-Methoxy-2-propanol Property

Melting point:

-84.2°C (estimate)

Boiling point:

118-119 °C

alpha 

20 º (c=10, CHCl3)

Density 

0.921 g/mL at 20 °C (lit.)

refractive index 

n20/D 1.403

Flash point:

33 °C

storage temp. 

Sealed in dry,2-8°C

solubility 

Chloroform (Sparingly), Methanol (Slightly)

pka

14.49±0.20(Predicted)

form 

Liquid

color 

Clear colorless

optical activity

[α]20/D +22±2°, c = 10% in chloroform

BRN 

1718940

Stability:

Volatile

InChIKey

ARXJGSRGQADJSQ-BYPYZUCNSA-N

CAS DataBase Reference

26550-55-0

Safety

Hazard Codes 

F

Risk Statements 

10-15

Safety Statements 

24-43-7/8-16

RIDADR 

UN 3092 3/PG 3

WGK Germany 

3

HazardClass 

3

PackingGroup 

Ⅲ

HS Code 

29094990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H320Causes eye irritation

H336May cause drowsiness or dizziness

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

(S)-(+)-1-Methoxy-2-propanol Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow liqui

Uses

(S)-(+)-1-Methoxy-2-propanol can be used as a reactant to prepare:

• (S)-1-methoxypropan-2-yl 4-methylbenzenesulfonate by reacting with tosyl chloride in the presence of pyridine.
• Thiazolopyridine urea derivatives.
• Quinazoline derivatives as potential inhibitors of EGFR/HER-2 tyrosine kinases.

Purification Methods

Wash the ethers with aqueous NaHCO3 in the presence of solid NaCl, dry them with MgSO4 and fractionally distil them. The RS-acetate [108-65-6] M 132.2 has b 145-146o/atm. The R(+) and S(-) enantiomers have [] D ±20.5o (c 10, H2O). [Beilstein 1 II 536, 1 III 2146, 1 IV 2471.]